Beta2-microglobulin concentrations in cerebrospinal fluid correlate with neuroimaging findings in newborns with symptomatic congenital cytomegalovirus infection

European Journal of Pediatrics

Volumn 165, Issue 9, 2006, Pages 636-645

  Alarcon, Ana ^b   Garcia Alix, Alfredo ^a   Cabañas, Fernando ^a   Hernanz, Angel ^a   Pascual Salcedo, Dora ^a   Martin Ancel, Ana ^b   Cabrera, Marta ^a   Tagarro, Alfredo ^a   Quero, Jose ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Beta2 microglobulin; Cerebrospinal fluid; Cytomegalovirus; Neuroimaging; Newborn

Indexed keywords

BETA 2 MICROGLOBULIN;

ARTICLE; BASAL GANGLION; BRAIN ATROPHY; BRAIN CALCIFICATION; BRAIN VENTRICLE; BRAIN VENTRICLE DILATATION; CLINICAL ARTICLE; CONGENITAL INFECTION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; ENCEPHALITIS; FEMALE; HOSPITAL DISCHARGE; HUMAN; MALE; MENINGOENCEPHALITIS; NEUROIMAGING; NEWBORN; NEWBORN INFECTION; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; SEPSIS; THALAMUS; APGAR SCORE; BRAIN; BRAIN DISEASE; CALCINOSIS; CASE CONTROL STUDY; CENTRAL NERVOUS SYSTEM INFECTION; CEREBROSPINAL FLUID; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL MALFORMATION; CYTOMEGALIC INCLUSION BODY DISEASE; DOPPLER ECHOGRAPHY; FOLLOW UP; HOSPITALIZATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; SPAIN; VIREMIA; VIROLOGY;

APGAR SCORE; BETA 2-MICROGLOBULIN; BRAIN; BRAIN DISEASES; CALCINOSIS; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM INFECTIONS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; MENINGOENCEPHALITIS; RESEARCH DESIGN; SEVERITY OF ILLNESS INDEX; SPAIN; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; VIREMIA;

EID: 33746552769     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-006-0160-x     Document Type: Article

References (50)

1. Amiel-Tison C, Grenier A (1986) Neurological assessment during the first year of life. Oxford University Press, New York
2. Bale JF, Bray PF, Bell WE (1985) Neuroradiographic abnormalities in congenital cytomegalovirus infection. Pediatr Neurol 1:42-77
3. Baquero-Artigao F, Mendez A, del Castillo F, Velazquez R (2004) Cerebrospinal fluid beta 2-microglobulin values in perinatally acquired cytomegalovirus infection. Pediatr Infect Dis J 23:891-892
4. Bernier GM (1980) Beta 2-microglobulin: structure, function and significance. Vox Sang 38:323-327
5. Boppana SB, Fowler KB, Vaid Y, Hedlund G, Stagno S, Britt WJ, Pass RF (1997) Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics 99:409-414
6. Boppana SB, Pass RF, Britt WJ, Stagno S, Alford CA (1992) Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality. Pediatr Infect Dis J 11:93-99
7. Bradford RD, Cloud G, Lakeman AD, Boppana S, Kimberlin DW, Jacobs R, Demmler G, Sanchez P, Britt W, Soong SJ, Whitley RJ (2005) Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system. J Infect Dis 191:227-233
8. Cabañas F, Pellicer A, Morales C, Garcia-Alix A, Stiris TA, Quero J (1994) New pattern of hyperechogenicity in thalamus and basal ganglia studied by color Doppler flow imaging. Pediatr Neurol 10:109-116
9. Conboy TJ, Pass RF, Stagno S, Alford CA, Myers GJ, Britt WJ, McCollister FP, Summers MN, McFarland CE, Boll TJ (1987) Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr 111:343-348
10. Cresswell P, Springer T, Strominger JL, Turner MJ, Grey HM, Kubo RT (1974) Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci 71(5):2123-2127
11. de Vries LS, Gunardi H, Barth PG, Bok LA, Verboon-Maciolek MA, Groenendaal F (2004) The spectrum of cranial ultrasound and magnetic resonance imaging abnormalities in congenital cytomegalovirus infection. Neuropediatrics 35:113-119
12. Evrin PE, Pertoft H (1973) Beta2-microglobulin in human blood cells. J Immunol 111:1147-1154
13. Frankenburg WK, Dodds JB (1967) The Denver developmental screening test. J Pediatr 71:181-191
14. Garcia- Alix A, Martin-Ancel A, Ramos MT, Salas S, Pellicer A, Cabañas F, Quero J (1995) Cerebrospinal fluid beta 2-microglobulin in neonates with central nervous system infections. Eur J Pediatr 154:309-313
15. Garcia-Alix A, Cabañas F, Pellicer A, Hernanz A, Stiris TA, Quero J (1994) Neuron-specific enolase and myelin basic protein: relationship of cerebrospinal fluid concentrations to the neurological condition of asphyxiated full-term infants. Pediatrics 93:234-240
16. Gekle D, Kult J, Roth R (1977) Lysozym und beta2-mikroglobulin in Liquor gesunder Kinder und bei Kinder mit Erkrankungen des Zentralnervensystem. Klin Wochenschr 55:189-191
17. Grey HM, Kubo RT, Colon SM, Poulik MD, Cresswell P, Springer T, Turner M, Strominger JL (1973) The small subunit of HL-A antigens is beta 2-microglobulin. J Exp Med 138:1608-1612
18. Hallgren R, Terent A, Venge P (1982) Lactoferrin, lysozyme, and beta 2-microglobulin levels in cerebrospinal fluid: differential indices of CNS inflammation. Inflammation 6:291-304
19. Inoue S, Takahashi H, Kaneko K (1994) The fluctuations of neuron-specific enolase (NSE) levels of cerebrospinal fluid during bacterial meningitis: the relationship between the fluctuations of NSE levels and neurological complications or outcome. Acta Paediatr Jpn 36:485-488
20. Kawai M, Hirohata S (2000) Cerebrospinal fluid beta(2)-microglobulin in neuro-Behcet's syndrome. J Neurol Sci 179:132-139
21. Kimberlin DW, Lin CY, Sanchez PJ, Demmler GJ, Dankner W, Shelton M, Jacobs RF, Vaudry W, Pass RF, Kiell JM, Soong SJ, Whitley RJ (2003) Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 143:16-25
22. Lanari M, Lazzarotto T, Venturi V, Papa I, Gabrielli L, Guerra B, Landini MP, Faldella G (2006) Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics 117:e76-e83
23. Levene MI (1981) Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child 56:900-904
24. Mavlight GM, Stuckey SE, Cabanillas FF, Keating MJ, Tourtellotte WW, Schold SC, Freireich EJ (1980) Diagnosis of leukemia or lymphoma in the central nervous system by beta 2-microglobulin determination. N Eng J Med 303:718-722
25. McArthur JC, Nance-Sproson TE, Griffin DE, Hoover D, Selnes OA, Miller EN, Margolick JB, Cohen BA, Farzadegan H, Saah A (1992) The diagnostic utility of elevation in cerebrospinal fluid beta 2-microglobulin in HIV-1 dementia. Multicenter AIDS Cohort Study. Neurology 42:1707-1712
26. Nigro G, Scholz H, Bartmann U (1994) Ganciclovir therapy for symptomatic congenital cytomegalovirus infection in infants: a two-regimen experience. J Pediatr 124:318-322
27. Nilsson K, Evrin PE, Welsh KI (1974) Production of beta 2-microglobulin by normal and malignant human cell lines and peripheral lymphocytes. Transplant Rev 21:53-58
28. Noyola DE, Demmler GJ, Nelson CT, Griesser C, Williamson WD, Atkins JT, Rozelle J, Turcich M, Llorente AM, Sellers-Vinson S, Reynolds A, Bale JF Jr, Gerson P, Yow MD (2001) Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr 138:325-331
29. Oksanen V, Gronhagen-Riska C, Tikanoja S, Somer H, Fyhrquist F (1986) Cerebrospinal fluid lysozyme and beta 2-microglobulin in neurosarcoidosis. J Neurol Sci 73:79-87
30. Pass RF, Stagno S, Myers GJ, Alford CA (1980) Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics 66:758-762
31. Pellicer A, Cabañas F, Garcia-Alix A, Perez Rodriguez J, Quero J (1993) Natural history of ventricular dilatation in preterm infants: prognostic significance. Pediatr Neurol 9:108-114
32. Pellicer A, Cabañas F, Perez-Higueras A, Garcia-Alix A, Quero J (1995) Neuronal migration disorders studied by cerebral ultrasound and colour Doppler flow imaging. Arch Dis Child Fetal Neonatal Ed 73:F55-F61
33. Peterslund NA, Black FT, Geil JP, Mogensen CE (1989) Beta-2-microglobulin in the cerebrospinal fluid of patients with infections of the central nervous system. Acta Neurol Scand 80:579-583
34. Ramsay, ME, Miller E, Peckham CS (1991) Outcome of confirmed cytomegalovirus infection. Arch Dis Child 66:1068-1069
35. Ries M, Deeg KH, Heininger U (1990) Demonstration of perivascular echogenicities in congenital cytomegalovirus infection by colour Doppler imaging. Eur J Pediatr 150:34-36
36. Rodriguez-Nuñez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M (2003) Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis. Brain Dev 25:102-106
37. Sarff LD, Platt LH, McCracken GH Jr (1976) Cerebrospinal fluid elevation in neonates: comparison of high risk infants with and without meningitis. J Pediatr 88:473-477
38. Stagno S (2001) Cytomegalovirus. In: Remington JS, Klein JD (eds) Infectious diseases of the fetus and newborn infant, 5th edn. WB Saunders, Philadelphia, pp 389-424
39. Starmans JJ, Vos J, van der Helm HJ (1977) The beta 2-microglobulin content of the cerebrospinal fluid in neurological disease. J Neurol Sci 33:45-49
40. 2-microglobulin in cerebrospinal fluid and diagnosis of neurosyphilis in an affected newborn. J Perinat Med 33:79-82
41. Takahashi S, Oki J, Miyamoto A, Moriyama T, Asano A, Inyaku F, Okuno A (1999) Beta-2-microglobulin and ferritin in cerebrospinal fluid for evaluation of patients with meningitis of different etiologies. Brain Dev 21:192-199
42. Teele RL, Hernanz-Schulman M, Sotrel A (1988) Echogenic vasculature in the basal ganglia of neonates: a sonographic sign of vasculopathy. Radiology 169:423-427
43. Tenhunen R, Iivanainen M, Kovanen J (1978) Cerebrospinal fluid beta 2-microglobulin in neurological disorders. Acta Neurol Scand 58:366-373
44. Thornberg E, Thiringer K, Hagberg H, Kjellmer I (1995) Neuron specific enolase in asphyxiated newborns: association with encephalopathy and cerebral function monitor trace. Arch Dis Child Fetal Neonatal Ed 72:F39-F42
45. Troendle Atkins J, Demmler GJ, Williamson WD, McDonald JM, Istas AS, Buffone GJ (1994) Polymerase chain reaction to detect cytomegalovirus DNA in the cerebrospinal fluid of neonates with congenital infection. J Infect Dis 169:1334-1337
46. Usher R, McLean F (1969) Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation. J Pediatr 74:901-910
47. Uson J, Balsa A, Pascual-Salcedo D, Cabezas JA, Gonzalez-Tarrio JM, Martin-Mola E, Fontan G (1997) Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J Rheumatol 24:2069-2075
48. Vicente V, Gonzalez M, Lopez Borrasca A (1982) Cerebrospinal fluid levels beta 2 microglobulin and ferritin in lymphoproliferative disorders. Acta Paediatr Scand 71:325-326
49. Volpe JJ (2001) Neurology of the newborn, 4th edn. WB Saunders, Philadelphia
50. Whitley RJ, Cloud G, Gruber W, Storch GA, Demmler GJ, Jacobs RF, Dankner W, Spector SA, Starr S, Pass RF, Stagno S, Britt WJ, Alford C Jr, Soong S, Zhou XJ, Sherrill L, FitzGerald JM, Sommadossi JP (1997) Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. J Infect Dis 175:1080-1081