Prophylactic administration of ponazuril reduces clinical signs and delays seroconversion in horses challenged with Sarcocystis neurona

Journal of Parasitology

Volumn 92, Issue 3, 2006, Pages 637-643

  Furr, M ^a   McKenzie, H ^a   Seville, W J A ^a,b   Dubey, J P ^a,c   Reed, S M ^a,b   Davis, W ^a,d  

^a MARION DUPONT SCOTT EQUINE MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

^d BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; MARQUIS; PONAZURIL; PROTOZOON ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY; DISEASE CONTROL; HORSE; NEUROLOGY; PARASITIC DISEASE; PROTOZOAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; AUTOPSY; BLOOD SAMPLING; CEREBROSPINAL FLUID; CONTROLLED STUDY; DISEASE SEVERITY; ENCEPHALOMYELITIS; EQUINE PROTOZOAL MYELOENCEPHALITIS; FEMALE; HORSE; INFECTION PREVENTION; INFLAMMATION; MALE; NEUROLOGIC EXAMINATION; NONHUMAN; PROTOZOAL INFECTION; SARCOCYSTIS NEURONA; SEROCONVERSION; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIPROTOZOAL AGENTS; BLOTTING, WESTERN; CELL COUNT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; ENCEPHALOMYELITIS; ERYTHROCYTE COUNT; FEMALE; HORSE DISEASES; HORSES; MALE; NEUROLOGIC EXAMINATION; RANDOM ALLOCATION; SARCOCYSTIS; SARCOCYSTOSIS; SEVERITY OF ILLNESS INDEX; TRIAZINES;

EQUIDAE; EQUUS CABALLUS; SARCOCYSTIS NEURONA;

EID: 33746512546     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/0022-3395(2006)92[637:PAOPRC]2.0.CO;2     Document Type: Article

References (23)

1. BENTZ, B. G., K. A. EALEY, J. MORROW, P. L. CLAYPOOL, AND J. T. SALIKI. 2003. Seroprevalence of antibodies to Sarcocystis neurona in equids residing in Oklahoma. Journal of Veterinary Diagnostic Investigation 15: 597-600.
2. BLYTHE, L. L., D. E. GRANSTROM, D. E. HANSEN, L. L. WALKER, J. BARTLETT, AND S. STAMPER. 1997. Seroprevalence of antibodies to Sarcocystis neurona in horses residing in Oregon. Journal of the American Veterinary Medical Association 210: 525-527.
3. -, -, AND S. STAMPER. 1997. Seroprevalence of antibodies to Sarcocystis neurona in horses residing in a county of southeastern Pennsylvania. Journal of the American Veterinary Medical Association 210: 517-518.
4. CUTLER, T. J., R. J. MACKAY, P. E. GINN, K. GILLIS, S. M. TANHAUSER, E. V. LERAY, J. B. DAME, AND E. C. GREINER. 2001. Immunoconversion against Sarcocystis neurona in normal and dexamethasonetreated horses challenged with S. neurona sporocysts. Veterinary Parasitology 95: 197-210.
5. DUBEY, J. P., D. FRITZ, D. S. LINDSAY, S. K. SHEN, O. C. H. KWOK, AND K. C. THOMPSON. 2001. Diclazuril preventive therapy of gamma interferon knockout mice fed Sarcocystis neurona sporocysts. Veterinary Parasitology 94: 257-263.
6. -, AND A. N. HAMIR. 2000. Immunohistochemical confirmation of Sarcocystis neurona infections in raccoons, mink, cat, skunk and pony. Journal of Parasitology 86: 1150-1152.
7. -, D. S. LINDSAY, W. J. A. SAVILLE, S. M. REED, D. E. GRANSTROM, AND C. A. SPEER. 2001. A review of Sarcocystis neurona and equine protozoal myeloencephalitis (EPM). Veterinary Parasitology 95: 89-131.
8. FENGER, C. K., D. E. GRANSTROM, A. A. GAJADHAR, N. M. WILLIAMS, S. A. McCRILLIS, S. STAMPER, J. L. LANGEMEIER, AND J. P. DUBEY. 1997. Experimental induction of equine protozoal myeloencephalitis in horses using Sarcocystis sp. sporocysts from the opossum (Didelphis virginiana). Veterinary Parasitology 68: 199-213.
9. FRANKLIN, R. P., R. J. MACKAY, K. D. GILLIS, S. M. TANHAUSER, P. E. GINN, AND T. J. KENNEDY. 2003. Effect of a single dose of ponazuril on neural infection and clinical disease in Sarcocystis neurona-challenged interferon-gamma knockout mice. Veterinary Parasitology 114: 123-130.
10. FURR, M., AND T. KENNEDY. 2001. Cerebrospinal fluid and serum concentrations of ponazuril in horses. Veterinary Therapeutics 2: 232-237.
11. -, T. KENNEDY, R. MACKAY, S. REED, F. ANDREWS, B. BERNARD, F. BAIN, AND D. BYARS. 2001. Efficacy of ponazuril 15% oral paste as a treatment for equine protozoal myeloencephalitis. Veterinary Therapeutics 2: 215-222.
12. -, R. MACKAY, D. GRANSTROM, H. SCHOTT, AND F. ANDREWS. 2002. Clinical diagnosis of equine protozoal myeloencephalitis (EPM). Journal of Veterinary Internal Medicine 16: 618-621.
13. JOHNSON, P. J. 1998. Managing to avoid EPM. Equine Athlete 11: 29-32.
14. LINDSAY, D. S., AND J. P. DUBEY. 2001. Determination of the activity of pyrantel tartrate against Sarcocystis neurona in γ-interferon gene knockout mice. Veterinary Parasitology 97: 141-144.
15. -, -, AND T. J. KENNEDY, 2000. Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures. Veterinary Parasitology 92: 165-169.
16. MAYHEW, I. G., A. DELAHUNTA, AND R. H. WHITLOCK. 1978. History and clinical evaluation [of spinal cord disease in horses]. Cornell Veterinarian (Supplement) 68: 24-35.
17. -, R. H. WHITLOCK, AND J. B. TASKER. 1977. Equine cerebrospinal fluid: Reference values of normal horses. American Journal of Veterinary Research 38: 1271-1274.
18. ROSSANO, M. G., H. C. SCHOTT, J. B. KANEENE, A. J. MURPHY, E. A. KRUTTLIN, M. T. HINES, D. C. SELLON, J. S. PATTERSON, H. M. ELSHEIKHA, J. P. DUBEY, AND L. S. MANSFIELD. 2005. Effect of daily administration of pyrantel tartrate in preventing infection in horses experimentally challenged with Sarcocystis neurona. American Journal of Veterinary Research 66: 846-852.
19. -, J. B. KANEENE, J. V. MARTENIUK, B. D. BANKS, H. C. SCHOTT, AND L. S. MANSFIELD. 2003. A herd-level analysis of risk factors for antibodies to Sarcocystis neurona in Michigan equids. Preventive Veterinary Medicine 57: 7-13.
20. SAVILLE, W. J. A., C. D. SOFALY, S. M. REED, J. P. DUBEY, M. J. OGLESBEE, V. A. LACOMBE, R. O. KEENE, K. M. GUGISBERG, S. W. SWENSEN, R. D. SHIPLEY, Y. W. CHIANG, H. J. CHU, AND T. NG. 2004. An equine protozoal myeloencephalitis challenge model testing a second transport after inoculation with Sarcocystis neurona sporocysts. Journal of Parasitology 90: 1406-1410.
21. -, R. W. STICH, S. M. REED, C. J. NJOKU, M. J. OGLESBEE, A. WUNSCHMANN, D. L. GROVER, A. L. LAREW-NAUGLE, J. F. STANEK, D. E. GRANSTROM, AND J. P. DUBEY. 2001. Utilization of stress in the development of an equine model for equine protozoal myeloencephalitis. Veterinary Parasitology 95: 211-222.
22. SOFALY, C. D., S. M. REED, J. C. GORDON, J. P. DUBEY, M. J. OGLESBEE, C. J. NJOKU, D. L. GROVER, AND W. J. A. SAVILLE. 2002. Experimental induction of equine protozoal myeloencephalitis (EPM) in the horse: Effect of Sarcocystis neurona sporocyst inoculation dose on the development of clinical neurologic disease. Journal of Parasitology 88: 1164-1170.
23. STANEK, J. F., J. P. DUBEY, M. J. OGLESBEE, S. M. REED, D. S. LINDSAY, L. A. CAPITINI, C. J. NJOKU, K. J. VITTITOW, AND W. J. A. SAVILLE. 2002. Life cycle of Sarcocystis neurona in its natural intermediate host, the raccoon, Procyon lotor. Journal of Parasitology 88: 1151-1158.