Dendritic cells pulsed with glioma lysates induce immunity against syngeneic intracranial gliomas and increase survival of tumor-bearing mice

Neurological Research

Volumn 28, Issue 5, 2006, Pages 527-531

  Pellegatta, S ^a   Poliani, P L ^b   Corno, D ^a   Grisoli, M ^a   Cusimano, M ^a   Ubiali, F ^a   Baggi, F ^a   Bruzzone, M G ^a   Finocchiaro, G ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Dendritic cells; Glioma; Immunotherapy

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; TUMOR ANTIGEN; TUMOR EXTRACT; TUMOR PROTEIN; TUMOR VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER RELAPSE; CD8+ T LYMPHOCYTE; CELL LINE; CELL LYSATE; CELL STRAIN GL261; CONTROLLED STUDY; DENDRITIC CELL; DRUG SAFETY; FEMALE; GLIOBLASTOMA; GLIOMA; HUMAN; IMMUNOCOMPETENCE; MOUSE; NONHUMAN; RELAPSE; SURVIVAL RATE; TUMOR IMMUNITY; VACCINATION;

ANIMALS; BONE MARROW CELLS; BRAIN NEOPLASMS; CANCER VACCINES; DENDRITIC CELLS; FLOW CYTOMETRY; GLIOBLASTOMA; IMMUNOTHERAPY; MICE;

EID: 33746512540     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164106X116809     Document Type: Article

References (12)

1. Ehtesham M, Black KL, Yu JS. Recent progress in immunotherapy for malignant glioma: Treatment strategies and results from clinical trials. Cancer Control 2004; 11: 192-207
2. Yu JS, Wheeler CJ, Zeltzer PM, et al. Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res 2001; 61: 842-847
3. Yu JS, Liu G, Ying H, et al. Vaccination with tumor lysale-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res 2004; 64: 4973-4979
4. Rutkowski S, De Vleeschouwer S, Kaempgen E, et al. Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study. Br J Cancer 2004; 91: 1656-1662
5. Yamanaka R, Homma J, Yajima N, et al. Clinical evaluation of dendritic cell vaccination for patients with recurrent glioma: Results of a clinical phase I/II trial. Clin Cancer Res 2005; 11: 4160-4167
6. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996
7. Akasaki Y, Black KL, Yu JS. Dendritic cell-based immunotherapy for malignant gliomas. Expert Rev Neurother 2005; 5: 497-508
8. Dunn GP, Ikeda H, Bruce AT, et al. Interferon-gamma and cancer immunoediting. Immunol Res 2005; 32: 231-246
9. Gilboa E. The promise of cancer vaccines. Nat Rev Cancer 2004; 4: 401-411
10. Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005; 5: 296-306
11. Matzinger P. The JAM test. A simple assay for DNA fragmentation and cell death. J Immunol Methods 1991; 145: 185-192
12. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004; 432: 396-401