Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice

British Journal of Ophthalmology

Volumn 90, Issue 8, 2006, Pages 1040-1045

  Fukushima, Atsuki ^a   Yamaguchi, T ^a   Azuma, M ^b   Yagita, H ^c   Ueno, H ^a  

^a KOCHI UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; HYBRID PROTEIN; IMMUNOGLOBULIN G; LIGAND; PROGRAM DEATH LIGAND 2; RAGWEED ANTIGEN; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; ALLERGIC CONJUNCTIVITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONJUNCTIVA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; FEMALE; HISTOLOGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SUPERNATANT; T LYMPHOCYTE ACTIVATION; UPREGULATION;

AMBROSIA; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD80; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; CONJUNCTIVA; CONJUNCTIVITIS, ALLERGIC; EOSINOPHILS; FEMALE; IMMUNITY, CELLULAR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; PEPTIDES; POLLEN; UP-REGULATION;

EID: 33746502513     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2006.091314     Document Type: Article

References (28)

1. Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis revisited: a case series of 195 patients with long-term followup. Ophthalmology 2000;107:1157-63.
2. Fukagawa K, Nakajima T, Tsubota K, et al. Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. J Allergy Clin Immunol 1999;103:1220-1.
3. Metz DP, Hingorani M, Calder VL, et al. T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol 1997;100:817-24.
4. Avunduk AM, Avunduk MC, Dayanir V, et al. A flow cytometric study about the immunopathology of vernal keratoconjunctivitis. J Allergy Clin Immunol 1998;101:821-4.
5. Leonardi A, DeFranchis G, Zancanaro F, et al. Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry. Invest Ophthalmol Vis Sci 1999;40:3036-40.
6. Matsuura N, Uchio E, Nakazawa M, et al. Predominance of infiltrating IL-4-producing T cells in conjunctiva of patients with allergic conjunctival disease. Curr Eye Res 2004;29:235-43.
7. Fukushima A, Fukata K, Ozaki A, et al. Exertion of the suppressive effects of IFN-γ on experimental immune mediated blepharoconjunctivitis in brown Norway rats during the induction phase but not the effector phase. Br J Ophthalmol 2002;86:1166-71.
8. Fukushima A, Ozaki A, Fukata K, et al. Ag-specific recognition, activation, and effector function of T cells in the conjunctiva with experimental immune-mediated blepharoconjunctivitis. Invest Ophthalmol Vis Sci 2003;44:4366-74.
9. Fukushima A, Yamaguchi T, Ishida W, et al. Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. Exp Eye Res (in press).
10. Ozaki A, Seki Y, Fukushima A, et al. The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. J Immunol 2005;175:5489-97.
11. June CH, Ledbetter JA, Gillespie MM, et al. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol 1987;7:4472-81.
12. Fukushima A, Yamaguchi T, Ishida W, et al. Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. J Immunol 2005;175:4897-903.
13. Fukushima A, Yamaguchi T, Ishida W, et al. Roles of OX40 in the development of murine experimental allergic conjunctivitis: exacerbation and attenuation of eosniophil infiltration by stimulation and blocking of OX40. Invest Ophthalmol Vis Sci (in press).
14. Fukushima A, Yamaguchi T, Ishida W, et al. The interaction between ICOS and B7RP-1 is not required for the development of experimental murine allergic conjunctivitis. Biochem Biophys Res Commun 2005;338:1726-31.
15. Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992;11:3887-95.
16. Agata Y, Kawasaki A, Nishimura H, et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.Int Immunol 1996;8:765-72.
17. Vibhakar R, Juan G, Traganos F, et al. Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp Cell Res 1997;232:25-8.
18. Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001;2:261-8.
19. Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol 2005;23:515-48.
20. Carter L, Fouser LA, Jussif J, et al. PD-1: PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol 2002;32:634-43.
21. Matsumoto K, Inoue H, Nakano T, et al. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. J Immunol 2004;172:2530-41.
22. Yamazaki T, Akiba H, Iwai H, et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol 2002;169:5538-45.
23. Tsushima F, Iwai H, Otsuki N, et al. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol 2003;33:2773-82.
24. Oflazoglu E, Swart DA, Anders-Bartholo P, et al. Paradoxical role of programmed death-1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo. Eur J Immunol 2004;34:3326-36.
25. Wang S, Bajorath J, Flies DB, et al. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med 2003;197:1083-91.
26. Shin T, Kennedy G, Gorski K, et al. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J Exp Med 2003;198:31-8.
27. Bellinghausen I, Knop J, Saloga J. The role of interleukin 10 in the regulation of allergic immune responses. Int Arch Allergy Immunol 2001;126:97-101.
28. Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol 2005;23:515-48.