Evaluation of Epsilon Amino-Caproic Acid (EACA) and Autologous Blood as Blood Conservation Strategies in Patients Undergoing Cardiac Surgery

Heart Lung and Circulation

Volumn 15, Issue 4, 2006, Pages 261-265

  Sharma, Vishal ^a   Talwar, Sachin ^a   Choudhary, Shiv Kumar ^a   Lakshmy, Rama ^a   Kale, Shailaja ^a   Kumar, Arkalgud Sampath ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Autologous blood; Blood conservation; Epsilon amino caproic acid

Indexed keywords

AMINOCAPROIC ACID; HEMOGLOBIN; HEPARIN; PROTAMINE; WARFARIN;

ADULT; ARTICLE; BLOOD AUTOTRANSFUSION; BLOOD CONSERVATION; BLOOD SAMPLING; BLOOD VOLUME; CALCULATION; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INFUSION; HEART SURGERY; HUMAN; INTRAOPERATIVE PERIOD; MAJOR CLINICAL STUDY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN INCISION; STATISTICAL SIGNIFICANCE; THORAX DRAINAGE;

6-AMINOCAPROIC ACID; ADULT; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION, AUTOLOGOUS; BLOOD VOLUME; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; FEMALE; HEMOSTASIS, SURGICAL; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE;

EID: 33746468200     PISSN: 14439506     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hlc.2006.03.014     Document Type: Article

References (14)

1. Havel M., Teufelsbauer H., and Knobl P. The effect of intra-operative aprotinin administration on post-operative bleeding in patients undergoing cardiopulmonary bypass surgery. J Thorac Cardiovasc Surg 101 (1991) 968-972
2. Knobl P.N., Zilla P., and Fasol R. The protein C system in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 94 (1987) 600-605
3. Hiratzka L.H., Richardson J.V., and Brandt B. The effect of autologous blood salvage techniques upon bank blood usage and cost of routine coronary revascularization. Perfusion 1 (1986) 239-244
4. Hoffman E.P., and Koo A.H. Cerebral thrombosis associated with Amicar. Radiology 131 (1979) 687-689
5. Naeye L. Thrombotic state after hemorrhagic diathesis, a possible complication of therapy with E-aminocaproic acid. Blood 19 (1962) 694-701
6. Rydin E., and Lundberg P.O. Tranexamic acid and intracranial thrombosis. Lancet 2 (1976) 49-51
7. Sonntang V.K.H., and Stein B.M. Arteriopathic complications during treatment of sub-arachnoid haemorrhage with E-aminocaproic acid. J Neurosurg 40 (1974) 480-485
8. Kaplan J.A., Cannarella C., and Jones E.L. Autologous blood transfusion during cardiac surgery. A re-evaluation of three methods. J Thorac Cardiovasc Surg 74 (1977) 4-10
9. Tempe D., Bajwa R., Cooper A., Nag B., Tomar A.S., Khanna S.K., et al. Blood conservation in small adults undergoing valve surgery. J Cardiothorac Vasc Anesth 10 (1996) 502-506
10. Diprose P., Herberston M.J., O'Shaughnessy D., Deakin C.D., and Gill R.S. Reducing allogenic transfusion in cardiac surgery:a randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intra-operative cell salvage. Br J Anaesth 94 (2005) 271-278
11. Penta de Peppo A., Pierri M.D., Scafuri A., De Paulis R., Coluntuono G., Capara E., et al. Intra-operative antifibrinolysis and blood-saving techniques in cardiac surgery. Prospective trial of 3 antifibrinolytic drugs. Tex Heart Inst J 22 (1995) 231-236
12. Levi M., Cromheecke M.E., de Jonge E., Prins M.H., de Mol B.J., Briet E., et al. Pharmacological strategies to decrease exsceesive blood loss in cardiac surgery: a meta-analysis of clinically relevant end points. Lancet 354 (1999) 1940-1947
13. Liu Y.C., and Tsai T.P. The effect of coagulation protection with combination of epsilon amino-caproic acid and plasma saver in open-heart surgery. Acta Anaesthesiol Scan 36 (1998) 149-154
14. Kochamba G.S., Pfeffer T.A., Sintek C.F., and Khonsari S. Intra-operative autotransfusion reduces blood loss after cardiopulmonary bypass. Ann Thorac Surg 61 (1996) 900-903