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33746401784
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Use of 5 equivalents of ylide 2 gave 3-hydroxypyrrolidine 8a in 13% yield
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Use of 5 equivalents of ylide 2 gave 3-hydroxypyrrolidine 8a in 13% yield
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25
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33746464293
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University of Oxford, During the preparation of this manuscript, the in situ process was reported:
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R. A. Jones, J. M. Schomaker and B. Borhan, Ylide-mediated expansion of 2,3-aziridin-1-ols to substituted pyrrolidines: Application to the syntheses of pyrrolizidine alkaloids, Abstracts of Papers, 231st ACS National Meeting, Atlanta, March 26-30, 2006, CHED-568
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Ylide-mediated Expansion of 2,3-aziridin-1-ols to Substituted Pyrrolidines: Application to the Syntheses of Pyrrolizidine Alkaloids, Abstracts of Papers, 231st ACS National Meeting, Atlanta, March 26-30, 2006, CHED-568
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Jones, R.A.1
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Borhan, B.3
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27
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33746420405
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-1, 10663 reflections were measured, R = 0.0423, wR = 0.0507. CCDC 602881. For crystallographic data in CIF or other electronic format see DOI:
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3S(O)Cl as a source of ylide 2 under these conditions gave an identical yield of 8a
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