Implication of inclusion complexation of glimepiride in cyclodextrin-polymer systems on its dissolution, stability and therapeutic efficacy

International Journal of Pharmaceutics

Volumn 320, Issue 1-2, 2006, Pages 53-57

  Ammar, H O ^a   Salama, H A ^a   Ghorab, M ^b   Mahmoud, A A ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Complexation; Cyclodextrins; Glimepiride; Stability; Water soluble polymers

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ANTIDIABETIC AGENT; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN SULFOBUTYL ETHER; GLIMEPIRIDE; HYDROXYPROPYLMETHYLCELLULOSE; K 30; MACROGOL 4000; MACROGOL 6000; MW 1380; MW 2160; POLYMER; POVIDONE;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOLUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG MIXTURE; DRUG STABILITY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLUBILITY; TABLET;

ADMINISTRATION, ORAL; ANIMALS; BETA-CYCLODEXTRINS; BLOOD GLUCOSE; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; HYPOGLYCEMIC AGENTS; KINETICS; MALE; METHYLCELLULOSE; POLYETHYLENE GLYCOLS; POLYMERS; POVIDONE; RABBITS; SOLUBILITY; SULFONYLUREA COMPOUNDS; TABLETS;

EID: 33746444733     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.04.002     Document Type: Article

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