Pradimicin therapy of disseminated Candida tropicalis infection in the mouse

Medical Mycology

Volumn 36, Issue 3, 1998, Pages 181-184

  Restrepo, M I ^a   Najvar, L K ^a   Fothergill, A W ^a   Graybill, J R ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

BMS; Candida tropicalis; Fluconazole; Mouse model; Pradimicin

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; BMS 181184; FLUCONAZOLE; PRADIMICIN A; PRADIMICIN B; PRADIMICIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA TROPICALIS; CANDIDIASIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; FUNGICIDAL ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NEUTROPENIA; NONHUMAN; ORAL DRUG ADMINISTRATION; SURVIVAL RATE;

AMPHOTERICIN B; ANIMALS; ANTHRACYCLINES; ANTIBIOTICS, ANTIFUNGAL; ANTIBIOTICS, ANTINEOPLASTIC; CANDIDA; CANDIDIASIS; DRUG RESISTANCE, MICROBIAL; FLUCONAZOLE; INJECTIONS, INTRAVENOUS; KIDNEY; MICE; MICROBIAL SENSITIVITY TESTS; SPLEEN;

EID: 33746433030     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-280X.1998.00134.x     Document Type: Article

References (6)

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2. Oki T, Tenmyo O, Hirano M, Tomatsu K, Kamei H. Pradimicins A, B, C. new antifungal antibiotics. II. In vitro and in vivo biological activities. J Antibiotics 1990; 43: 763-70.
3. Wingard JR, Merz WG, Saral R. Candida tropicalis: a major pathogen in immunocompromised patients. Ann Intern Med 1979; 91: 539-43.
4. Graybill JR, Najvar, LK, Holmberg JD, Luther MF. Fluconazole, D0870, and flucytosine treatment of disseminated Candida tropicalis infections in mice. Antimicrob Agents Chemother 1995; 39: 924-9.
5. National Committee for Clinical Laboratory Standards. Reference method for broth dilution anlifungal susceptibility testing for yeasts: proposed standard M27-P. Villanova, PA: National Committee for Clinical Laboratory Standards, 1992.
6. Graybill JR, Najvar LK, Holmberg JD, Correa A, Luther MF. Fluconazole treatment of Candida albicans infection in mice: does in vitro susceptibility predict in vivo response? Antimicrob Agents Chemother 1995; 39: 2197-200.