Antibiotic beads and osteomyelitis: Here today, what's coming tomorrow?

Orthopedics

Volumn 29, Issue 7, 2006, Pages 599-603

  Kent, Molly E ^a   Rapp, Robert P ^b   Smith, Kelly M ^b,c  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b University of Kentucky   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BONE CEMENT; CALCIUM; CALCIUM SULFATE; CEFAZOLIN; CIPROFLOXACIN; CLINDAMYCIN; GENTAMICIN BONE CEMENT; MICROSPHERE; OSTEOSET PELLETS; OSTEOSET T; POLY(METHYL METHACRYLATE); POLYGLACTIN; POLYLACTIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TICARCILLIN; TOBRAMYCIN; VANCOMYCIN;

ARTICLE; BIODEGRADATION; BONE INFECTION; CALCIUM BLOOD LEVEL; DEBRIDEMENT; DRUG BLOOD LEVEL; DRUG BONE LEVEL; DRUG DELIVERY SYSTEM; DRUG RELEASE; FRACTURE HEALING; HOSPITALIZATION; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MOBILIZATION; NONHUMAN; OSTEOMYELITIS; SEROMA; UNSPECIFIED SIDE EFFECT;

EID: 33746403752     PISSN: 01477447     EISSN: None     Source Type: Journal    
DOI: 10.3928/01477447-20060701-02     Document Type: Article

References (25)

1. Garvin K, Feschuk C. Polylactide-polyglycolide antibiotic implants. Clin Orthop. 2005; 437:105-110.
2. Kanellakopoulou K, Giamarellos-Bourboulis EJ. Carrier systems for the local delivery of antibiotics in bone infections. Drugs. 2000; 59:1223-1232.
3. Adams K, Couch L, Cierny G, Calhoun J, Mader JT. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop. 1992; 278:244-252.
4. Mader JT, Calhoun J, Cobos J. In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads. Antimicrob Agents Chemother. 1997; 41:415-418.
5. Blaha JD, Calhoun JH, Nelson CL, et al. Comparison of the clinical efficacy and tolerance of gentamicin PMMA beads on surgical wire versus combined and systemic therapy for osteomyelitis. Clin Orthop. 1993; 295:8-12.
6. Patzakis MJ, Mazur K, Wilkins J, Sherman R, Holtom P. Septopal beads and autogenous bone grafting for bone defects in patients with chronic osteomyelitis. Clin Orthop. 1993; 295:112-118.
7. Shih HN, Shih LY, Wong YC. Diagnosis and treatment of sub-acute osteomyelitis. J Trauma. 2005; 58:83-87.
8. Nelson CL, Griffin FM, Harrison BH, Cooper RE. In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads. Clin Orthop. 1992; 284:303-309.
9. Klemm K. The use of antibiotic-containing bead chains in the treatment of chronic bone infections. Clin Microbiol Infect. 2001; 7:28-31.
10. Rushton N. Applications of local antibiotic therapy. Eur J Surg Suppl. 1997; 578:27-30.
11. Wilson KJ, Cierny G, Adams KR, Mader JT. Comparative evaluation of the diffusion of tobramycin and cefotaxime out of antibiotic-impregnated polymethylmethacrylate beads. J Orthop Res. 1988; 6:279-286.
12. Seligson D, Popham GJ, Voos K, Henry SL, Faghri M. Antibiotic-leaching from polymethylmethacrylate beads. J Bone Joint Surg Am. 1993; 75:714-720.
13. Kuechle DK, London GC, Musher DM, Noble PC. Elution of vancomycin, daptomycin, and amikacin from acrylic bone cement. Clin Orthop. 1991; 264:302-308.
14. Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS, Bolander ME, Patel R. Ciprofloxacin inhibition of experimental fracture healing. J Bone Joint Surg Am. 2000; 82:161-173.
15. Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop. 1996; 333:245-251.
16. Isefuku S, Joyner CJ, Simpson AH. Gentamicin may have an adverse effect on osteogenesis. J Orthop Trauma. 2003; 17:212-216.
17. Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE. Bone toxicity of locally applied aminoglycosides. J Orthop Trauma. 1995; 9:401-406.
18. Hanssen AD. Local antibiotic delivery vehicles in the treatment of musculoskeletal infection. Clin Orthop. 2005; 437:91-96.
19. Calhoun JH, Henry SL, Anger DM, Cobos JA, Mader JT. The treatment of infected nonunions with gentamicin-polymethylmethacrylate antibiotic beads. Clin Orthop. 1993; 295:23-27.
20. McKee MD, Wild LM, Schemitsch EH, Waddell JP. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma. 2002; 16:622-627.
21. Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong). 2002; 10:53-60.
22. Calhoun JH, Mader JT. Treatment of osteomyelitis with a biodegradable antibiotic implant. Clin Orthop. 1997; 341:206-214.
23. Ambrose CG, Clyburn TA, Louden K, et al. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clin Orthop. 2004; 421:293-299.
24. Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002; 20:643-647.
25. Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop. 2005; 437:97-104.