Scaffold-free, engineered porcine cartilage construct for cartilage defect repair - In vitro and in vivo study

Artificial Organs

Volumn 30, Issue 8, 2006, Pages 586-596

  Park, Kwideok ^a   Huang, Jinsong ^b   Azar, Frederick ^b   Jin, Ri L ^c   Min, Byoung Hyun ^c   Han, Dong K ^a   Hasty, Karen ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c Ajou University School of Medicine   (South Korea)

Author keywords

Articular cartilage; Cartilage injury repair; Chondrocytes; Scaffold free engineered cartilage; Tissue engineering

Indexed keywords

ASCORBIC ACID; ASSAYS; BODY FLUIDS; CELLS; COLLAGEN; CYTOLOGY; DEFECTS; ETHYLENEDIAMINETETRAACETIC ACID; POLYMERASE CHAIN REACTION; REPAIR; SCAFFOLDS (BIOLOGY);

ARTICULAR CARTILAGES; CARTILAGE INJURY REPAIR; CHONDROCYTES; COLLAGEN GELS; ENGINEERED CARTILAGE; EXTRACELLULAR MATRICES; GLYCOSAMINOGLYCANS; IN-VITRO; SCAFFOLD-FREE ENGINEERED CARTILAGE; TISSUES ENGINEERINGS;

CARTILAGE;

ASCORBIC ACID; COLLAGEN GEL; EDETIC ACID; GLYCOSAMINOGLYCAN; TRYPSIN;

ALLOGRAFT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL COUNT; CELL CULTURE EQUIPMENT; CELL GROWTH; CELL ISOLATION; CELL VIABILITY; CENTRIFUGATION; CHEMICAL ANALYSIS; CHONDROPATHY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULE; MONOLAYER CULTURE; MORPHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; TISSUE CULTURE; TISSUE ENGINEERING;

LACUNA; SUIDAE; SUS SCROFA DOMESTICA;

EID: 33746397618     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2006.00267.x     Document Type: Article

References (37)

1. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95.
2. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2001;10:432-63.
3. O'Driscoll SW. Articular cartilage regeneration using periosteum. Clin Orthop 1999;367S:186-203.
4. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-6.
5. Gao J, Dennis JE, Solchaga LA, Awadallah AS, Goldberg VM, Caplan AI. Tissue-engineered fabrication of an osteochondral composite graft using rat bone marrow-derived mesenchymal stem cells. Tissue Eng 2001;7 (4):363-71.
6. Solchaga LA, Goldberg VM, Caplan AI. Cartilage Regeneration Using Principles of Tissue Engineering. Clin Orthop 2001;391S:S161-70.
7. Freed LE, Grande DA, Lingbin Z, Emmanual J, Marquis JC, Langer R. Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res 1994;28:891-9.
8. Frenkel SR, Toolan B, Menche D, Pitman MI, Pachence JM. Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. J Bone Joint Surg Br 1997;79B:831-6.
9. Kuo CK, Ma PX. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part I. Structure, gelation rate and mechanical properties. Biomaterials 2001;22:511-21.
10. Suh JK, Howard MWT. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 2000;21:2589-98.
11. Solchaga LA, Temenoff JS, Gao J, Mikos AG, Caplan AI, Goldberg VM. Repair of osteochondral defects with hyaluronan-and polyester-based scaffolds. Osteoarthritis Cartilage 2005;13:297-309.
12. Grande DA, Halberstadt C, Naughton G, Schwartz R, Manji R. Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. J Biomed Mater Res 1997;34:211-20.
13. Sittinger M, Reitzel D, Dauner M, et al. Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes. J Biomed Mater Res 1996;33:57-63.
14. Anderer U, Libera J. In vitro engineering of human autogenous cartilage. J Bone Miner Res 2002;17:1420-9.
15. Stewart MC, Saunders KM, Burton-wurster M, Macleod JN. Phenotypic stability of articular chondrocytes in vitro: the effects of culture models, bone morphogenetic protein 2, and serum supplementation. J Bone Miner Res 2000;15:166-74.
16. Zhang Z, McCaffery M, Spencer RG, Francomano CA. Hyaline cartilage engineered by chondrocytes in pellet culture: histological, immunohistochemical and ultrastructural analysis in comparison with cartilage explants. J Anat 2004;205:229-37.
17. Byron CR, Benson BM, Stewart AA, Stewart MC. Effects of radial shock waves on membrane permeability and viability of chondrocytes and structure of articular cartilage in equine cartilage explants. Am J Vet Res 2005;66:1757-63.
18. Gigout A, Jolicoeur M, Buschmann MD. Low calcium levels in serum-free media maintain chondrocyte phenotype in monolayer culture and reduce chondrocyte aggregation in suspension culture. Osteoarthritis Cartilage 2005;13:1012-24.
19. Masuda K, Sah R, Hejna M, Thonar EJMA. A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocytes (ARC) method. J Orthop Res 2003;21:139-48.
20. Adkisson HD, Gillis MP, Davis EC, Maloney W, Hruska KA. In vitro generation of scaffold independent neocartilage. Clin Orthop 2001;391S:S280-94.
21. Grogan SP, Rieser B, Winkelmann HFP, Berardi S, Mainil-Varlet P. A static, closed and scaffold-free bioreactor system that permits chondrogenesis in vitro. Osteoarthritis Cartilage 2003;11:403-11.
22. Marlovits S, Tichy B, Truppe M, Gruber D, Vecsei V. Chondrogenesis of aged human articular cartilage in a scaffold-free bioreactor. Tissue Eng 2003;9:1215-26.
23. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;833:173-7.
24. Shimizu T, Yamato M, Kikuchi A, Okano T. Cell sheet engineering for myocardial tissue reconstructions. Biomaterials 2003;24:2309-16.
25. Watt FM. Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture. J Cell Sci 1988;89:373-8.
26. Mauck RL, Wang C, Oswald ES, Ateshian GA, Hung CT. The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading. Osteoarthritis Cartilage 2003;11:879-90.
27. Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, Grodzinsky AJ. Self-assembling peptide hydrogel fosters chondrocytes extracellular matrix production and cell division: Implications for cartilage tissue repair. PNAS 2002;99:9996-10001.
28. Strehl R, Schumacher K, de Vries U, Minuth WW. Proliferating cells versus differentiated cells in tissue engineering. Tissue Eng 2002;8:37-42.
29. Barbero A, Grogan S, Schafer D, Heberer M, Mainil-Varlet P, Martin I. Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. Osteoarthritis Cartilage 2004;12:476-84.
30. Kino-Oka M, Yashiki S, Ota Y, Mushiaki Y, Sugawara K, Yamamoto T, Takezawa T, Taya M. Subculture of chondrocytes on a collagen type I-coated substrate with suppressed cellular dedifferentiation. Tissue Eng 2005;11:597-608.
31. Veilleux N, Spector M. Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. Osteoarthritis Cartilage 2005;13:278-86.
32. Lee CR, Breinan HA, Nehrer S, Spector M. Articular Cartilage chondrocytes in type I and II collagen-GAG matrices exhibit contractile behavior in vitro. Tissue Eng 2000;6:555-65.
33. Pacifici M, Golden EB, Adams SL, Shapiro IM. Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytes. Exp Cell Res 1991;192:266-70.
34. Estrada LE, Dodge GR, Richardson DW, Farole A, Jimenez SA. Characterization of a biomaterial with cartilage-like properties expressing type X collagen generated in vitro using neonatal porcine articular and growth plate chondrocytes. Osteoarthritis Cartilage 2001;9:169-77.
35. Grande DA. Cartilage tissue engineering: current limitations and solutions. Clin Orthop 1999;367S:S176-85.
36. Obradovic B, Martin I, Padera RF, Treppo S, Freed LE, Vunjak-Novakovic G. Integration of engineered cartilage. J Orthp Res 2001;19:1089-97.
37. Wakitani S, Goto T, Young RG, Mansour JM, Goldberg VM, Caplan AI. Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. Tissue Eng 1998;4:429.