Emerging approaches in molecular profiling affecting oncology drug discovery

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 70, Issue , 2005, Pages 445-448

  Friend, S H ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ROSETTA INPHARMATICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GEMCITABINE; CELL CYCLE PROTEIN; CISPLATIN; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTL PROTEIN HOMOLOG 1; PROTEIN KINASE C; PROTEIN P53; SMALL INTERFERING RNA;

BIOLOGICAL MODEL; CONFERENCE PAPER; DNA FINGERPRINTING; DRUG IDENTIFICATION; DRUG INDUSTRY; GENETIC ANALYSIS; HUMAN; MOLECULAR RECOGNITION; ONCOLOGY; PATIENT CARE; PRIORITY JOURNAL; AMINO ACID SYNTHESIS; ARTICLE; BREAST CANCER; CARBOHYDRATE METABOLISM; DOMINANCE BEHAVIOR; DRUG RESEARCH; GENE EXPRESSION REGULATION; NONHUMAN; SACCHAROMYCES CEREVISIAE;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION PROFILING; HUMANS; NEOPLASMS; RNA, SMALL INTERFERING;

EID: 33746384886     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2005.70.028     Document Type: Conference Paper

References (5)

1. Dai H., van't Veer L., Lamb J., He Y.D., Mao M., Fine B.M., Bernards R., van de Vijver M., Deutsch P., Sachs A., Stoughton R., and Friend S.H. 2005. A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res. 65: 4059.
2. Hartwell L.H. and Weinert T.A. 1989. Checkpoints: Controls that ensure the order of cell cycle events. Science 246: 629.
3. Hughes T.R., Marton M.J., Jones A.R., Roberts C.J., Stoughton R., Armour C.D., Bennett H.A., Coffey H., Dai H., He Y.D., Kidd M.J., King A.M., Meyer M.R., Slade D., Lum P.Y., Stepaniants S.B., Shoemaker D.D., Gachotte D., Chakraburtty K., Simon J., Bard M., and Friend S.H. 2000. Functional discovery via a compendium of expression profiles. Cell 102: 109.
4. Roberts C.J., Nelson B., Marton M.J., Stoughton R., Meyer M.R., Bennett H.A., He Y., Dai H., Walker W., Hughes T., Tyers M., Boone C., and Friend S.H. 2000. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287: 873.
5. Van't Veer L.J., Dai H., Van de Vijver M.J., He Y.D., Hart A.A.M., Mao M., Peterse H.L., Van der Kooy K., Marton M.J., Witteveen A.T., Schreiber G.J., Kerkhoven R.M., Roberts C.J., Linsley P.S., Bernards R., and Friend S.H. 2002. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415: 530.