Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines

International Archives of Allergy and Immunology

Volumn 140, Issue 4, 2006, Pages 315-320

  Traidl Hoffmann, C ^a,b   Munster I ^a   Ring, J ^a   Behrendt, H ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antihistamine; Chemotaxis; Desloratadine; Keratinocytes; Loratadine

Indexed keywords

ANTIHISTAMINIC AGENT; DESLORATADINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; LORATADINE; RANTES; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COMMUNICATION; CELL MIGRATION; CONTROLLED STUDY; EOSINOPHIL; HUMAN; HUMAN CELL; IC 50; IMMUNE RESPONSE; KERATINOCYTE; LEUKOCYTE; LEUKOCYTE ACTIVATION; NEUTROPHIL; PRIORITY JOURNAL; SKIN NECROSIS; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANTI-INFLAMMATORY AGENTS; CELL COMMUNICATION; CELL MOVEMENT; CHEMOKINES, CC; CHEMOKINES, CXC; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; HISTAMINE H1 ANTAGONISTS; HUMANS; INTERFERON TYPE II; KERATINOCYTES; LEUKOCYTES; LORATADINE; NEUTROPHILS; TH1 CELLS; TH2 CELLS;

EID: 33746357552     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093709     Document Type: Article

References (18)

1. Haria M, Fitton A, Peters DH: Loratadine: a reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs 1994;48:617-637.
2. Ring J, Hein R, Gauger A: Desloratadine in the treatment of chronic idiopathic urticaria. Allergy 2001;56(suppl 65):28-32.
3. Kleine-Tebbe J, Josties C, Frank G, Stalleicken D, Buschauer A, Schunack W, Kunkel G, Czarnetzki B: Inhibition of IgE- and non-IgE-mediated histamine release from human basophil leukocytes in vitro by a histamine H1-antagonist, desethoxycarbonyl-loratadine. J Allergy Clin Immunol 1994;93:494-500.
4. Assanasen P, Naclerio RM: Antiallergic anti-inflammatory effects of H1-antihistamines in humans. Clin Allergy Immunol 2002;17:101-139.
5. Lugovic L, Lipozenic J, Jakic-Razumovic J: Prominent involvement of activated Th1 subset of T cells and increased expression of receptor for IFN-γ on keratinocytes in atopic dermatitis acute skin lesions. Int Arch Allergy Immunol 2005;137:125-133.
6. Albanesi C, Cavani A, Girolomini G: Interferon-stimulated human keratinocytes express the genes necessary for the production of peptide-loaded MHC class II molecules. J Invest Dermatol 1998;75:138-142.
7. Pastore S, Mascia F, Maritati F, Dattilo C, Girolomoni G: Chemokine networks in inflammatory skin diseases. Eur J Dermatol 2004;14:203-208.
8. Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzoni S, Girolomini G: A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J Leukoc Biol 2001;70:617-623.
9. Lippert U, Kruger-Krasagakes S, Moller A, Kiessling U, Czarnetzki BM: Pharmacological modulation of IL-6 and IL-8 secretion by the H1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines. Exp Dermatol 1995;4:272-276.
10. Traidl C, Sebastiani S, Albanesi C, et al: Disparate cytotoxic activity of nickel-specific CD8+ and CD4+ T cell subsets against keratinocytes. J Immunol 2000;165:3058-3064.
11. Traidl-Hoffmann C, Kasche A, Jakob T, Huger M, Plotz S, Feussner I, Ring J, Behrendt H: Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes. J Allergy Clin Immunol 2002;109:831-838.
12. Plötz SG, Traidl-Hoffmann C, Feussner I, Kasche A, Feser A, Ring J, Jakob T, Behrendt H: Chemotaxis and activation of human peripheral blood eosinophils induced by pollen-associated lipid mediators. J Allergy Clin Immunol 2004;113:1152-1160.
13. Giustizieri ML, Albanesi C, Fluhr J, Gisondi P, Norgauer J, Girolomoni G: H1-histamine receptor mediates inflammatory responses in human keratinocytes. J Allergy Clin Immunol 2004;114:1176-1182.
14. Albanesi C, Pastore S, Fanales-Belasio E, Girolomoni G: Cetirizine and hydrocortisone differentially regulate ICAM-1 expression and chemokine release in cultured human keratinocytes. Clin Exp Allergy 1998;28:101-109.
15. Wu RL, Anthes JC, Kreutner W, Harris AG, West RE Jr: Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-κB activity consistent with inverse agonism at the histamine H1-receptor. Int Arch Allergy Immunol 2004;135:313-318.
16. Baldwin SA: The NF-B and IBB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-681.
17. Michel L, De Vos C, Rihoux JP, Burtin C, Benveniste J, Dubertret L: Inhibitory effect of oral desloratadine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. J Allergy Clin Immunol 1988;82:101-109.
18. Simons FE, Murray HE, Simons KJ: Quantitation of H1-receptor antagonists in skin and serum. J Allergy Clin Immunol 1995;95:759-764.