Is the rat pancreas an appropriate model of the human pancreas?

Pancreatology

Volumn 6, Issue 3, 2006, Pages 180-190

  Case, R Maynard ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Anatomy; Disease models; Ductal secretion; Electrolyte secretion; Microanatomy; Regulation; Secretory patterns

Indexed keywords

BETA ADRENERGIC RECEPTOR; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; SECRETIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACINAR CELL; ACUTE PANCREATITIS; CAT; CLINICAL RESEARCH; DISEASE EXACERBATION; DISEASE MODEL; DISEASE SIMULATION; ELECTROLYTE EXCRETION; HEMORRHAGIC PANCREATITIS; HORMONE RELEASE; IMMUNOCYTOCHEMISTRY; NONHUMAN; PANCREAS ACINUS; PANCREAS DUCT; PANCREAS FUNCTION; PANCREAS SECRETION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 33746330405     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000091849     Document Type: Article

References (73)

1. European Pancreatic Club: Deuxième Colloque Européen du Pancréas. Arch Fr Malad Appareil Dig 1967;56:993-1006.
2. Pedrazzoli S: 36th European Pancreatic Club (EPC) Meeting. Pancreatology 2004;4:129-212.
3. Mann FC, Foster JP, Brimhall SD: The relation of the common bile duct to the pancreatic duct in common domestic and laboratory animals. J Lab Clin Med 1920;5:203-206.
4. Takahashi M, Pour P, Althoff J, Donnelly T: The pancreas of the Syrian hamster (Mesocricetus auratus). 1. Anatomical study. Lab Anim Sci 1977;27:336-342.
5. Blackstone M: Pancreatitis from bile relflux - again? Gastroenterology 2003;124:863-864.
6. Murakami T, Fujita T, Miyake T, Ohtsuka A, Taguchi T, Kikuta A: The insulo-acinar portal and insulo-venous drainage systems in the pancreas of the mouse, dog, monkey and certain other animals: a scanning electron microscopic study of corrosion casts. Arch Histol Cytol 1993;56:127-147.
7. Case RM, Argent BE: Pancreatic secretion of electrolytes and water; in Schultz SG, Forte JG, Rauner BE (eds): Handbook of Physiology - The Gastrointestinal System. New York, Oxford University Press, 1989, vol III, sect 6, pp 20:383-417.
8. Domschke S, Domschke W, Rösch W, Konturek SJ, Wünsch E, Demling L: Bicarbonate and cyclic AMP content of pure human pancreatic juice in response to graded doses of synthetic secretin. Gastroenterology 1976;70:533-536.
9. Hart WH, Thomas JE: Bicarbonate and chloride of pancreatic juice secreted in response to various stimuli. Gastroenterology 1945;4:409-420.
10. Debas HT, Grossman MI: Pure cholecystokinin: pancreatic protein and bicarbonate response. Digestion 1973;9:469-481.
11. Case RM, Harper AA, Scratcherd T: The secretion of electrolytes and enzymes by the pancreas of the anaesthetized cat. J Physiol 1969;201:335-348.
12. Lenninger S, Ohlin P: The flow of juice from the pancreatic gland of the cat in response to vagal stimulation. J Physiol 1971;216:303-318.
13. Sewell WA, Young JA: Secretion of electrolytes by the pancreas of the anaesthetized rat. J Physiol 1975;252:379-396.
14. Chariot J, Rozé C, de La Tour J, Vaille C: Stimulation vagale non cholinergique de la sécrétion pancréatique externe chez le rat. Gastroenterol Clin Biol 1982;6:371-378.
15. Seow KTFP, Case RM, Young JA: Pancreatic secretion by the anaesthetized rabbit in response to secretin, cholecystokinin, and carbachol. Pancreas 1991;6:385-391.
16. Holst JJ, Schaffalitzky de Muckadell OB, Fahrenkrug J: Nervous control of pancreatic exocrine secretion in pigs. Acta Physiol Scand 1979;105:33-51.
17. Jensen SL, Rehfeld JF, Holst JJ, Nielsen OV, Fahrenkrug J, Schaffalitzky de Muckadell OB: Secretory effects of cholecystokinins on the isolated perfused porcine pancreas. Acta Physiol Scand 1981;111:225-231.
18. Padfield PJ, Garner A, Case RM: Patterns of pancreatic secretion in the anaesthetised guinea pig following stimulation with secretin, cholecystokinin octapeptide, or bombesin. Pancreas 1989;4:204-209.
19. Ali AE, Rutishauser SCB, Case RM: Pancreatic and biliary secretion in the anesthetized Syrian golden hamster in response to secretin, cholecystokinin-octapeptide, bombesin, and carbachol. Pancreas 1990;5:314-322.
20. Fernández-Salazar MP, Pascua P, Calvo JJ, López MA, Case RM, Steward MC, San Roman JI: Basolateral anion transport mechanisms underlying fluid secretion by mouse, rat and guinea-pig pancreatic ducts. J Physiol 2004;556:415-428.
21. Case RM, Argent BE: Pancreatic duct cell secretion: control and mechanisms of transport; in Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds): The Pancreas: Biology, Pathobiology and Disease, ed 2. New York, Raven Press, 1993, pp 301-350.
22. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD: Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 2001;121:1380-1390.
23. Miyasaka K, Shinozaki H, Jimi A, Funakoshi A: Amlyase secretion from dispersed human pancreatic acini: neither cholecystokinin A nor cholecystokinin B receptors mediate amylase secretion in vitro. Pancreas 2002;25:161-165.
24. Bourassa J, Lainé J, Kruse M-L, Gagnon M-C, Calvo E, Morisset J: Ontogeny and species differences in the pancreatic expression and localization of the CCKA receptors. Biochem Biophys Res Commun 1999;260:820-828.
25. Owyang C, Logsdon CD: New insights into neurohormonal regulation of pancreatic secretion. Gastroenterology 2004;127:957-969.
26. Sundler F, Alumets J, Håkanson R, Fahrenkrug J, Schaffalitzky de Muckadell O: Peptidergic (VIP) nerves in the pancreas. Histochemistry 1978;55:173-176.
27. - secretion in guinea-pig pancreatic duct. J Physiol 1999;591:551-558.
28. Kordás KS, Sperlágh B, Tihanyi T, Topa L, Steward MC, Varga G, Kittel A: ATP and ATPase secretion by exocrine pancreas in rat, guinea pig, and human. Pancreas 2004;29:53-60.
29. Bolender RP: Stereological analysis of the guinea pig pancreas. 1. Analytical model and quantitative description of nonstimulated pancreatic exocrine cells. J Cell Biol 1974;61:269-287.
30. Case RM: Synthesis, intracellular transport and discharge of exportable proteins in the pancreatic acinar cell and other cells. Biol Rev 1978;53:211-354.
31. Githens S: The pancreatic duct cell: proliferative capabilities, specific characteristics, metaplasia, isolation, and culture. J Pediatr Gastroenterol Nutr 1988;7:486-506.
32. Kodama T: A light and electron microscopic study on the pancreatic ductal system. Acta Pathol Jpn 1983;33:297-321.
33. Marino CR, Matovcik LM, Gorelick FS, Cohn JA: Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. J Clin Invest 1991;88:712-716.
34. Crawford I, Maloney PC, Zeitlin PL, Guggino WB, Hyde SC, Turley H, Gatter KC, Harris A, Higgins CF: Immunocytochemical localization of the cystic fibrosis gene product CFTR. Proc Natl Acad Sci USA 1991;88:9262-9266.
35. - cotransporter in human pancreas. Am J Physiol 1999;277:G487-G494.
36. Burghardt B, Elkjær M-L, Kwon T-H, Rácz GZ, Varga G, Steward MC, Nielsen S: Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut 2003;52:1008-1016.
37. - cotransporter (NBC-1) variants in rat and human pancreas. Am J Physiol 2003;284:C729-C737.
38. Zeng W, Lee MG, Yan M, Diaz J, Benjamin I, Marino CR, Kopito R, Freedman S, Cotton C, Muallem S, Thomas P: Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. Am J Physiol 1997;273:C442-C455.
39. Furuya S, Naruse S, Ko SBH, Ishiguro H, Yoshikawa T, Hayakawa T: Distribution of aquaporin 1 in the rat pancreatic duct system examined with light- and electron-microscopic immunohistochemistry. Cell Tissue Res 2002;308:75-86.
40. Ko SBH, Naruse S, Kitagawa M, Ishiguro H, Furuya S, Mizuno N, Wang Y, Yoshikawa T, Suzuki A, Shimano S, Hayakawa T: Aquaporins in rat pancreatic interlobular ducts. Am J Physiol 2002;282:G324-G331.
41. Takahashi-Iwanaga H, Yanase H, Orikasa M: Reexamination of the fine structure of the pancreatic duct system in the rat: a proposal of morphological segmentation. Biomed Res 2003;24:77-87.
42. Petersen OH: Electrophysiology of salivary and pancreatic acinar cells; in Johnson LR (ed): Physiology of the Gastrointestinal Tract, ed 3. New York, Raven Press, 1994, pp 1025-1059.
43. Rosado JA, Singh J, Salido GM, Garcia LJ: Acetylcholine-evoked potassium transport in the isolated guinea-pig pancreas. Exp Physiol 1997;82:149-159.
44. Petersen OH, Findlay I, Iwatsuki N, Singh J, Gallacher DV, Fuller CM, Pearson GT, Dunne MJ, Morris AP: Human pancreatic acinar cells: studies of stimulus-secretion coupling. Gastroenterology 1985;89:109-117.
45. Gromada J, Jørgensen NK, Nauntofte B, Dissing S: Stimulation-induced calcium signalling and ion transport in rat pancreatic acini. Acta Physiol Scand 1997;159:69-79.
46. Steward MC, Ishiguro H, Case RM: Mechanism of bicarbonate secretion in the pancreatic duct. Ann Rev Physiol 2005;67:377-409.
47. Ishiguro H, Naruse S, Steward MC, Kitagawa M, Ko SBH, Hayakawa T, Case RM: Fluid secretion in interlobular ducts isolated from guinea-pig pancreas. J Physiol 1998;511:407-422.
48. 3 secretion in pigs. Acta Physiol Scand 1986;126:593-600.
49. Gray MA, Winpenny JP, Porteous DJ, Dorin JR, Argent BE: CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse. Am J Physiol 1994;266:C213-C221.
50. Winpenny JP, Verdon B, McAlroy HL, Colledge WH, Ratcliff R, Evans MJ, Gray MA, Argent BE: Calcium-activated chloride conductance is not increased in pancreatic duct cells of CF mice. Pflügers Arch 1995;430:26-33.
51. Winpenny JP, Harris A, Hollingsworth MA, Argent BE, Gray MA: Calcium-activated chloride conductance in a pancreatic adenocarcinoma cell line of ductal origin (HPAF) and in freshly isolated human pancreatic duct cells. Pflügers Arch 1998;435:796-803.
52. - transport in ducts isolated from the pancreas of CFTR null mice; abstract. Pancreatology 2004;4:199.
53. Klöppel G, Maillet B: Pathology of chronic pancreatitis; in Beger G, Warshaw AL, Büchler MV, Carr-Locke DL, Neoptolemos JP, Russell C, Sarr MG (eds): The Pancreas. Oxford, Blackwell, 1998, vol 1, pp 720-723.
54. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS: Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin. Pancreas 2003;27:297-300.
55. Deng X, Wood PG, Eagon PK, Whitcomb DC: Chronic alcohol-induced alterations in the pancreatic secretory control mechanisms. Dig Dis Sci 2004;49:805-819.
56. Sparmann G, Merkord J, Jäschke A, Nizze H, Jonas L, Löhr M, Liebe S, Emmrich J: Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology 1997;112:1664-1672.
57. Inoue M, Ino Y, Gibo J, Ito T, Hisano T, Arita Y, Nawata H: The role of monocyte chemoattractant protein-1 in experimental chronic pancreatitis model induced by dibutyltin dichloride in rats. Pancreas 2002;25:64-70.
58. Su S-B, Motoo Y, Xie M-J, Sawabu N: Apoptosis in rat spontaneous chronic pancreatitis. Role of the Fas and Fas ligand system. Dig Dis Sci 2001;46:166-175.
59. Jiang P-H, Motoo Y, Vaccaro MI, Iovanna JL, Okada G, Sawabu N: Expression of vacuole membrane protein 1 (VMP1) in spontaneous chronic pancreatitis in the WBN/Kob rat. Pancreas 2004;29:225-230.
60. Austin JL, Roberts C, Rosenholtz MJ, Reber HA: Effects of partial duct obstruction and drainage on pancreatic function. J Surg Res 1980;28:426-433.
61. Okumura N, Sakakibara A, Hayakawa T, Noda A: Pancreatic endocrine function in experimental pancreatolithiasis in dogs. Am J Gastroenterol 1982;77:392-396.
62. De Giorgio R, Sternini C, Widdison AL, Alvarez C, Brecha NC, Reber HA, Go VLW: Differential effects of experimentally induced chronic pancreatitis on neuropeptide immunoreactivities in the feline pancreas. Pancreas 1993;8:700-710.
63. Patel AG, Toyama MT, Alvarez C, Nguyen TH, Reber PU, Ashley SW, Reber HA: Pancreatic interstitial pH in human and feline chronic pancreatitis. Gastroenterology 1995;109:1639-1645.
64. Lombardi B, Estes LW, Longnecker DS: Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. American Journal of Pathology 1975;79:465-480.
65. Delaney CP, McGeeney KF, Dervan P, Fitzpatrick JM: Pancreatic atrophy: a new model using serial intra-peritoneal injections of L-arginine. Scand J Gastroenterol 1993, 28:1086-1090.
66. Oshio G, Saluja A, Steer ML: Effects of short-term pancreatic duct obstruction in rats. Gastroenterology 1991;100:196-202.
67. Mooren FC, Hlouschek V, Finkes T, Turi S, Weber IA, Singh J, Domschke W, Schnekenburger J, Krüger B, Lerch MM: Early changes in pancreatic aciner cell calcium signalling after pancreatic duct obstruction. J Biol Chem 2003;278:9361-9369.
68. Aho HJ, Koskensalo SM-L, Nevalainen TJ: Experimental pancreatitis in the rat: sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 1980;15:411-416.
69. Lerch MM, Saluja AK, Runzi M, Dawra R, Saluja M, Steer ML: Pancreatic duct obstruction triggers acute necrotizing pancreatitis in the opossum. Gastroenterology 1993;104:853-861.
70. Lampel M, Kern HF: Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch [A] 1977;373:97-117.
71. Singh VP, Saluja AK, Bhagat L, van Acker GJD, Song AM, Soltoff SP, Cantley LC, Steer ML: Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest 2001;108:1387-1394.
72. Schmid SW, Modlin IM, Tang LH, Stoch A, Rhee S, Nathanson MH, Scheele GA, Gorelick FS: Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. Am J Physiol 1998;274:G734-G741.
73. Chaudhuri A, Kolodecik TR, Gorelick FS: Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell. Am J Physiol 2005;288:G235-G243.