Dacarbazine induces genotoxic and cytotoxic germ cell damage with concomitant decrease in testosterone and increase in lactate dehydrogenase concentration in the testis

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 607, Issue 2, 2006, Pages 240-252

  Kumar, S Ganesh ^a   Narayana, K ^b   Bairy, K L ^c   D'Souza, Urban J A ^d   Samuel, Vijaya Paul ^a   Gopalakrishna, K ^c  

^a MELAKA MANIPAL MEDICAL COLLEGE   (India)

^b KUWAIT UNIVERSITY   (Kuwait)

^c KASTURBA MEDICAL COLLEGE   (India)

^d UNIVERSITI MALAYSIA SABAH   (Malaysia)

Author keywords

Azoospermia; Chemotherapy; Cytotoxicity; Oligospermia; Sperm abnormality; Sperm count; Testicular dysfunction

Indexed keywords

DACARBAZINE; LACTATE DEHYDROGENASE; TESTOSTERONE;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DAMAGE; CELL VACUOLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYTOTOXICITY; DOSE RESPONSE; EPIDIDYMIS; GENOTOXICITY; GERM CELL; HISTOPATHOLOGY; MALE; MORPHOLOGY; MOUSE; NONHUMAN; OLIGOSPERMIA; POST HOC ANALYSIS; PRIORITY JOURNAL; SAMPLING; SEMINIFEROUS TUBULE EPITHELIUM; SKIN EXFOLIATION; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; TESTIS; TESTIS FUNCTION; TESTIS WEIGHT; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; DACARBAZINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDIDYMIS; L-LACTATE DEHYDROGENASE; MALE; MICE; OLIGOSPERMIA; ORGAN SIZE; SEMINIFEROUS TUBULES; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS; TESTOSTERONE;

EID: 33746320207     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.04.019     Document Type: Article

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