Investigation of low-abundant in vitro metabolites of stable isotope-labelled BAL4815 by accurate mass capillary-LC-ESI-qTof-MS and MS/MS

Journal of Mass Spectrometry

Volumn 41, Issue 7, 2006, Pages 903-910

  Wind, Mathias ^a   Spickermann, Jochen ^a   Schleimer, Michael ^a   Donzelli, Massimiliano ^a   Gebhardt, Klaus ^a   Sturm Haurany, Rima ^a   Klauer, Dominique ^a   Fullhardt, Pascal ^a   Schmitt Hoffmann, Anne ^a  

^a BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

Accurate mass; Azole; Electrospray; Glutathione; Mass spectrometry; Metabolism

Indexed keywords

DEUTERIUM COMPOUNDS; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE TRANSITIONS;

ACCURATE MASS; AZOLE; ELECTROSPRAY; GLUTATHIONE;

METABOLITES;

4 [2 [2 (2,5 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 4 THIAZOLYL]BENZONITRILE; ACETYLCYSTEINE; ANTIFUNGAL AGENT; CYSTEINE; DEUTERIUM; DRUG ANALOG; DRUG METABOLITE; GLUTATHIONE; ISOTOPE; PYRROLE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CELL CULTURE; CELL LEVEL; DEFLUORINATION; DEGRADATION; DRUG DETERMINATION; DRUG LABELING; DRUG METABOLISM; DRUG MIXTURE; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INCUBATION TIME; LIVER CELL; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANIMALS; ANTIFUNGAL AGENTS; CAPILLARITY; CHROMATOGRAPHY, LIQUID; DEUTERIUM; HEPATOCYTES; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; MODELS, MOLECULAR; NITRILES; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRIAZOLES;

EID: 33746293272     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1049     Document Type: Article

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