메뉴 건너뛰기




Volumn 14, Issue 4, 2006, Pages 200-204

Cardiovascular effects of erythropoietin: Anemia and beyond

Author keywords

Anemia; Erythropoietin; Heart failure; Ischemia; Myocardial infarction

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; FERROUS GLUCONATE; FOLIC ACID; FUROSEMIDE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PLACEBO;

EID: 33746290205     PISSN: 10615377     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.crd.0000195223.85556.8e     Document Type: Review
Times cited : (11)

References (49)
  • 1
    • 0032737391 scopus 로고    scopus 로고
    • Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients
    • Macdougall IC, Gray SJ, Elston O, et al. Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients. Am Soc Nephrol. 1999;10:2392-2395.
    • (1999) Am Soc Nephrol , vol.10 , pp. 2392-2395
    • Macdougall, I.C.1    Gray, S.J.2    Elston, O.3
  • 2
    • 0025762177 scopus 로고
    • Therapy with recombinant human EPO reduces cardiac size and improves heart function in chronic hemodialysis patients
    • Low-Friedrich I, Grutzmacher P, Marz W, et al. Therapy with recombinant human EPO reduces cardiac size and improves heart function in chronic hemodialysis patients. Am J Nephrol. 1991;11:54-60.
    • (1991) Am J Nephrol , vol.11 , pp. 54-60
    • Low-Friedrich, I.1    Grutzmacher, P.2    Marz, W.3
  • 3
    • 0032947921 scopus 로고    scopus 로고
    • What are the short-term and long-term consequences of anaemia in CRF patients?
    • Mann JF. What are the short-term and long-term consequences of anaemia in CRF patients? Nephrol Dial Transplant. 1999;14(suppl 2):29-36.
    • (1999) Nephrol Dial Transplant , vol.14 , Issue.2 SUPPL. , pp. 29-36
    • Mann, J.F.1
  • 4
    • 0037258964 scopus 로고    scopus 로고
    • Drugs for increasing oxygen and their potential use in doping: A review
    • Gaudard A, Varlet-Marie E, Bressolle F, et al. Drugs for increasing oxygen and their potential use in doping: a review. Sports Med. 2003;33:187-212.
    • (2003) Sports Med , vol.33 , pp. 187-212
    • Gaudard, A.1    Varlet-Marie, E.2    Bressolle, F.3
  • 5
    • 4143062393 scopus 로고    scopus 로고
    • Tainted glory - Doping and athletic performance
    • Noakes TD. Tainted glory - doping and athletic performance. N Engl J Med. 351:847-849.
    • N Engl J Med , vol.351 , pp. 847-849
    • Noakes, T.D.1
  • 6
    • 7944231471 scopus 로고    scopus 로고
    • EPO is a multifunctional tissue-protective cytokine
    • Erbayraktar S, Yilmaz O, Gokmen N, et al. EPO is a multifunctional tissue-protective cytokine. Curr Hematol Rep. 2003;2:465-470.
    • (2003) Curr Hematol Rep , vol.2 , pp. 465-470
    • Erbayraktar, S.1    Yilmaz, O.2    Gokmen, N.3
  • 7
    • 0037443954 scopus 로고    scopus 로고
    • EPO and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation
    • Stuckmann I, Evans S, Lassar AB. EPO and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation. Dev Biol. 2003;255:334-349.
    • (2003) Dev Biol , vol.255 , pp. 334-349
    • Stuckmann, I.1    Evans, S.2    Lassar, A.B.3
  • 8
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of EPO that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G, et al. Derivatives of EPO that are tissue protective but not erythropoietic. Science. 2004;305:239-242.
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3
  • 9
    • 0037133191 scopus 로고    scopus 로고
    • EPO prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
    • Celik M, Gokmen N, Erbayraktar S, et al. EPO prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci U S A. 2002;99:2258-2263.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2258-2263
    • Celik, M.1    Gokmen, N.2    Erbayraktar, S.3
  • 10
    • 0037047154 scopus 로고    scopus 로고
    • Recombinant human EPO counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
    • Gorio A, Gokmen N, Erbayraktar S, et al. Recombinant human EPO counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci U S A. 2002;99:9450-9455.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9450-9455
    • Gorio, A.1    Gokmen, N.2    Erbayraktar, S.3
  • 11
    • 3042688444 scopus 로고    scopus 로고
    • Treatment of stroke with EPO enhances neurogenesis and angiogenesis and improves neurological function in rats
    • Wang L, Zhang Z, Wang Y, et al. Treatment of stroke with EPO enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004;35:1732-1737.
    • (2004) Stroke , vol.35 , pp. 1732-1737
    • Wang, L.1    Zhang, Z.2    Wang, Y.3
  • 12
    • 0035957426 scopus 로고    scopus 로고
    • EPO prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • Siren AL, Fratelli M, Brines M, et al. EPO prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci U S A. 2001;98:4044-4049.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4044-4049
    • Siren, A.L.1    Fratelli, M.2    Brines, M.3
  • 13
    • 9144237424 scopus 로고    scopus 로고
    • EPO both protects from and reverses experimental diabetic neuropathy
    • Bianchi R, Buyukakilli B, Brines M, et al. EPO both protects from and reverses experimental diabetic neuropathy. Proc Natl Acad Sci U S A. 2004;101:823-828.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 823-828
    • Bianchi, R.1    Buyukakilli, B.2    Brines, M.3
  • 14
    • 0036678821 scopus 로고    scopus 로고
    • EPO administration protects retinal neurons from acute ischemia-reperfusion injury
    • Junk AK, Mammis A, Savitz SI, et al. EPO administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2002;99:10659-10664.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10659-10664
    • Junk, A.K.1    Mammis, A.2    Savitz, S.I.3
  • 15
    • 4344626952 scopus 로고    scopus 로고
    • Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial akt and attenuates progressive organ failure
    • Bahlmann FH, Song R, Boehm SM, et al. Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial akt and attenuates progressive organ failure. Circulation. 2004;110:1006-1012.
    • (2004) Circulation , vol.110 , pp. 1006-1012
    • Bahlmann, F.H.1    Song, R.2    Boehm, S.M.3
  • 16
    • 0036705708 scopus 로고    scopus 로고
    • EPO therapy for acute stroke is both safe and beneficial
    • Ehrenreich H, Hasselblatt M, Dembowski C, et al. EPO therapy for acute stroke is both safe and beneficial. Mol Med. 2002;8:495-505.
    • (2002) Mol Med , vol.8 , pp. 495-505
    • Ehrenreich, H.1    Hasselblatt, M.2    Dembowski, C.3
  • 17
    • 0037392297 scopus 로고    scopus 로고
    • EPO improves cardiac contractility in post-hypoxic mice
    • Sterin-Borda L, Barcelo AC, Bozzini CE. EPO improves cardiac contractility in post-hypoxic mice. Br J Haematol. 2003;121:180-186.
    • (2003) Br J Haematol , vol.121 , pp. 180-186
    • Sterin-Borda, L.1    Barcelo, A.C.2    Bozzini, C.E.3
  • 18
    • 8844247185 scopus 로고    scopus 로고
    • Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia-reperfusion injury
    • Van der Meer P, Lipsic E, Henning RH, et al. Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia-reperfusion injury. Eur J Heart Fail. 2004;6:853-859.
    • (2004) Eur J Heart Fail , vol.6 , pp. 853-859
    • Van Der Meer, P.1    Lipsic, E.2    Henning, R.H.3
  • 19
    • 0141593556 scopus 로고    scopus 로고
    • EPO reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats
    • Moon C, Krawczyk M, Ahn D, et al. EPO reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats. Proc Natl Acad Sci U S A. 2003;100:11612-11617.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11612-11617
    • Moon, C.1    Krawczyk, M.2    Ahn, D.3
  • 20
    • 0037447256 scopus 로고    scopus 로고
    • Recombinant human EPO protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
    • Calvillo L, Latini R, Kajstura J, et al. Recombinant human EPO protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci U S A. 2003;100:4802-4806.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4802-4806
    • Calvillo, L.1    Latini, R.2    Kajstura, J.3
  • 21
    • 9644297877 scopus 로고    scopus 로고
    • Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia
    • Abdelrahman M, Sharples EJ, McDonald MC, et al. Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. Shock. 2004;22:63-69.
    • (2004) Shock , vol.22 , pp. 63-69
    • Abdelrahman, M.1    Sharples, E.J.2    McDonald, M.C.3
  • 22
    • 85047691007 scopus 로고    scopus 로고
    • A novel protective effect of EPO in the infarcted heart
    • Parsa CJ, Matsumoto A, Kim J, et al. A novel protective effect of EPO in the infarcted heart. J Clin Invest. 2003;112:999-1007.
    • (2003) J Clin Invest , vol.112 , pp. 999-1007
    • Parsa, C.J.1    Matsumoto, A.2    Kim, J.3
  • 23
    • 2442714969 scopus 로고    scopus 로고
    • Cardioprotective effects of EPO in the reperfused ischemic heart: A potential role for cardiac fibroblasts
    • Parsa CJ, Kim J, Riel RU, et al. Cardioprotective effects of EPO in the reperfused ischemic heart: a potential role for cardiac fibroblasts. J Biol Chem. 2004;279:20655-20662.
    • (2004) J Biol Chem , vol.279 , pp. 20655-20662
    • Parsa, C.J.1    Kim, J.2    Riel, R.U.3
  • 24
    • 4644227714 scopus 로고    scopus 로고
    • Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion
    • Lipsic E, van der Meer P, Henning RH, et al. Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion. J Cardiovasc Pharmacol. 2004;44:473-479.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 473-479
    • Lipsic, E.1    Van Der Meer, P.2    Henning, R.H.3
  • 25
    • 13844320400 scopus 로고    scopus 로고
    • A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury
    • Fiordaliso F, Chimenti S, Staszewsky L, et al. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2005;102:2046-2051.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2046-2051
    • Fiordaliso, F.1    Chimenti, S.2    Staszewsky, L.3
  • 26
    • 3042752765 scopus 로고    scopus 로고
    • Anemia in chronic heart failure: Pathogenetic mechanisms
    • Okonko DO, Anker SD. Anemia in chronic heart failure: pathogenetic mechanisms. J Card Fail. 2004;10:S5-S9.
    • (2004) J Card Fail , vol.10
    • Okonko, D.O.1    Anker, S.D.2
  • 27
    • 0036896347 scopus 로고    scopus 로고
    • The importance of anemia and its correction in the management of severe congestive heart failure
    • Silverberg DS, Wexler D, Iaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Fail. 2002;4:681-686.
    • (2002) Eur J Heart Fail , vol.4 , pp. 681-686
    • Silverberg, D.S.1    Wexler, D.2    Iaina, A.3
  • 28
    • 3242799671 scopus 로고    scopus 로고
    • Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure
    • Van der Meer P, Voors AA, Lipsic E, et al. Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure. J Am Coll Cardiol. 2004;44:63-67.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 63-67
    • Van Der Meer, P.1    Voors, A.A.2    Lipsic, E.3
  • 29
    • 0042708597 scopus 로고    scopus 로고
    • Outcomes of anemia management in renal insufficiency and cardiac disease
    • Silverberg D. Outcomes of anemia management in renal insufficiency and cardiac disease. Nephrol Dial Transplant. 2003;18:ii7-ii12.
    • (2003) Nephrol Dial Transplant , vol.18
    • Silverberg, D.1
  • 30
    • 0034128813 scopus 로고    scopus 로고
    • The use of subcutaneous EPO and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations
    • Silverberg DS, Wexler D, Blum M, et al. The use of subcutaneous EPO and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol. 2000;35:1737-1744.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1737-1744
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 31
    • 0037458095 scopus 로고    scopus 로고
    • Anemia is common in heart failure and is associated with poor outcomes: Insights from a cohort of 12,065 patients with new-onset heart failure
    • Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12,065 patients with new-onset heart failure. Circulation. 2003;107:223-225.
    • (2003) Circulation , vol.107 , pp. 223-225
    • Ezekowitz, J.A.1    McAlister, F.A.2    Armstrong, P.W.3
  • 32
    • 3142688226 scopus 로고    scopus 로고
    • Anemia and its relationship to clinical outcome in heart failure
    • Anand I, McMurray JJ, Whitmore J, et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004;110:149-154.
    • (2004) Circulation , vol.110 , pp. 149-154
    • Anand, I.1    McMurray, J.J.2    Whitmore, J.3
  • 33
    • 0043011312 scopus 로고    scopus 로고
    • Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure
    • Felker GM, Gattis WA, Leimberger JD, et al. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. Am J Cardiol. 2003;92:625-628.
    • (2003) Am J Cardiol , vol.92 , pp. 625-628
    • Felker, G.M.1    Gattis, W.A.2    Leimberger, J.D.3
  • 34
    • 16644390538 scopus 로고    scopus 로고
    • Mechanisms and treatment of anemia in chronic heart failure
    • Katz SD. Mechanisms and treatment of anemia in chronic heart failure. Congest Heart Fail. 2004;10:243-247.
    • (2004) Congest Heart Fail , vol.10 , pp. 243-247
    • Katz, S.D.1
  • 35
    • 12844272142 scopus 로고    scopus 로고
    • Use of erythropoietin in heart failure management
    • Caiola K, Cheng JW. Use of erythropoietin in heart failure management. Ann Pharmacother. 2004;38:2145-2149.
    • (2004) Ann Pharmacother , vol.38 , pp. 2145-2149
    • Caiola, K.1    Cheng, J.W.2
  • 36
    • 2942565665 scopus 로고    scopus 로고
    • Anemia management in heart failure: A thick review of thin data
    • McBride BF, White CM. Anemia management in heart failure: a thick review of thin data. Pharmacotherapy. 2004;24:757-767.
    • (2004) Pharmacotherapy , vol.24 , pp. 757-767
    • McBride, B.F.1    White, C.M.2
  • 37
    • 0034812030 scopus 로고    scopus 로고
    • Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction
    • Al-Ahmad A, Rand WM, Manjunath G, et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2001;38:955-962.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 955-962
    • Al-Ahmad, A.1    Rand, W.M.2    Manjunath, G.3
  • 38
    • 0035370037 scopus 로고    scopus 로고
    • The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous EPO and intravenous iron: A randomized controlled study
    • Silverberg DS, Wexler D, Sheps D, et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous EPO and intravenous iron: a randomized controlled study. J Am Coll Cardiol. 2001;37:1775-1780.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1775-1780
    • Silverberg, D.S.1    Wexler, D.2    Sheps, D.3
  • 39
    • 0142138797 scopus 로고    scopus 로고
    • EPO should be part of congestive heart failure management
    • Silverberg DS, Wexler D, Blum M, et al. EPO should be part of congestive heart failure management. Kidney Int Suppl. 2003;S40-S47.
    • (2003) Kidney Int Suppl
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 40
    • 0037261601 scopus 로고    scopus 로고
    • Anemia in chronic kidney disease and congestive heart failure
    • Silverberg DS, Wexler D, Blum B, et al. Anemia in chronic kidney disease and congestive heart failure. Blood Purif. 2003;21:124-130.
    • (2003) Blood Purif , vol.21 , pp. 124-130
    • Silverberg, D.S.1    Wexler, D.2    Blum, B.3
  • 41
    • 12244284657 scopus 로고    scopus 로고
    • The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous EPO and intravenous iron
    • Silverberg DS, Wexler D, Blum M, et al. The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous EPO and intravenous iron. Nephrol Dial Transplant. 2003;18:141-146.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 141-146
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 42
    • 0037458127 scopus 로고    scopus 로고
    • Effect of EPO on exercise capacity in patients with moderate to severe chronic heart failure
    • Mancini DM, Katz SD, Lang CC, et al. Effect of EPO on exercise capacity in patients with moderate to severe chronic heart failure. Circulation. 2003;107:294-299.
    • (2003) Circulation , vol.107 , pp. 294-299
    • Mancini, D.M.1    Katz, S.D.2    Lang, C.C.3
  • 43
    • 0141888206 scopus 로고    scopus 로고
    • Researchers probe anemia-heart failure link
    • Mitka M. Researchers probe anemia-heart failure link. JAMA. 2003;290:1835-1838.
    • (2003) JAMA , vol.290 , pp. 1835-1838
    • Mitka, M.1
  • 44
    • 0024445405 scopus 로고
    • EPO levels are normalized during treatment of congestive heart failure with enalapril
    • Fyhrquist F, Karppinen K, Honkanen T, et al. EPO levels are normalized during treatment of congestive heart failure with enalapril. J Intern Med. 1989;226:257-260.
    • (1989) J Intern Med , vol.226 , pp. 257-260
    • Fyhrquist, F.1    Karppinen, K.2    Honkanen, T.3
  • 45
    • 0028124805 scopus 로고
    • Blood levels of EPO in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profiles
    • Volpe M, Tritto C, Testa U, et al. Blood levels of EPO in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profiles. Am J Cardiol. 1994;74:468-473.
    • (1994) Am J Cardiol , vol.74 , pp. 468-473
    • Volpe, M.1    Tritto, C.2    Testa, U.3
  • 46
    • 0037160736 scopus 로고    scopus 로고
    • Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: A prospective randomised trial
    • Plata R, Cornejo A, Arratia C, et al. Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: a prospective randomised trial. Lancet. 2002;359:663-666.
    • (2002) Lancet , vol.359 , pp. 663-666
    • Plata, R.1    Cornejo, A.2    Arratia, C.3
  • 47
    • 18744431818 scopus 로고    scopus 로고
    • The impact of withdrawing ACE inhibitors on erythropoietin responsiveness and left ventricular hypertrophy in haemodialysis patients
    • Erturk S, Nergizoglu G, Ates K, et al. The impact of withdrawing ACE inhibitors on erythropoietin responsiveness and left ventricular hypertrophy in haemodialysis patients. Nephrol Dial Transplant. 1999;14:1912-1916.
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 1912-1916
    • Erturk, S.1    Nergizoglu, G.2    Ates, K.3
  • 48
    • 0029819150 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor therapy in chronic hemodialysis patients: Any evidence of EPO resistance?
    • Cruz DN, Perazella MA, Abu-Alfa AK, et al. Angiotensin-converting enzyme inhibitor therapy in chronic hemodialysis patients: any evidence of EPO resistance? Am J Kidney Dis. 1996;28:535-540.
    • (1996) Am J Kidney Dis , vol.28 , pp. 535-540
    • Cruz, D.N.1    Perazella, M.A.2    Abu-Alfa, A.K.3
  • 49
    • 0031970298 scopus 로고    scopus 로고
    • High dose enalapril impairs the response to EPO treatment in haemodialysis patients
    • Albitar S, Genin R, Fen-Chong M, et al. High dose enalapril impairs the response to EPO treatment in haemodialysis patients. Nephrol Dial Transplant. 1998;13:1206-1210.
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 1206-1210
    • Albitar, S.1    Genin, R.2    Fen-Chong, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.