The development of conformational-dynamics-based sensors

Angewandte Chemie - International Edition

Volumn 45, Issue 16, 2006, Pages 2565-2567

  Kele, Péter ^a   Nagy, Krisztina ^a   Kotschy, András ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Conformational dynamics; Crown compounds; Fluorescence; Photoinduced electron transfer; Sensors

Indexed keywords

ELECTRON TRANSITIONS; FLUORESCENCE; SIGNAL PROCESSING;

CONFORMATIONAL DYNAMICS; CROWN COMPOUNDS; PHOTOINDUCED ELECTRON TRANSFER;

SENSORS;

EID: 33746281764     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200504335     Document Type: Article

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13. Although sensors 2c and 2d were synthesized in an enantiopure form, their potential for enantioselective recognition is not part of the presented study.
14. There are two possible explanations for the effect exerted by conformational dynamics on the fluorescent signal. The first builds on the changes of the stochastic frequency and amplitude profile of intramolecular movements caused by covalent substitution, whereas the other advocates a change in the static equilibrium structure accompanying the supramolecular modification. At present, we presume that simple sensor molecules are better described by the first approach, whereas for the characterization of supramolecular complexes, the second approach might be more relevant. Experimental and modeling studies aimed at refining this picture are in progress.