A straightforward synthetic approach to antitumoral pyridinyl substituted 7H-indeno[2,1-c]quinoline derivatives via three-component imino Diels-Alder reaction

Letters in Organic Chemistry

Volumn 3, Issue 4, 2006, Pages 300-304

  Kouznetsov, Vladimir V ^a   Puentes, Christian Ochoa ^a   Bohórquez, Arnold R Romero ^a   Zacchino, Susana A ^b   Sortino, Maximiliano ^b   Gupta, Mahabir ^c   Vázquez, Yelkaira ^c   Bahsas, Ali ^d   Amaro Luis, Juan ^d  

^a UNIVERSIDAD INDUSTRIAL DE SANTANDER   (Colombia)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^c UNIVERSIDAD DE PANAMÁ   (Panama)

^d UNIVERSIDAD DE LOS ANDES   (Venezuela)

Author keywords

Antitumoral and antifungal activities; Imino Diels Alder reaction; Indeno 2,1 c quinolines; Multi component reaction

Indexed keywords

EID: 33746280550     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017806776114595     Document Type: Article

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43. 3 CFU/ ml Microtiters trays were incubated at 35 °C for yeasts and hialophyphomycetes and at 28-30°C for dermatophyte strains in a moist, dark chamber and MICs were recorded at 48 h for yeasts, and at a time according to the control fungus growth, for the rest of fungi. See, NCCLS, National Committee for Clinical Laboratory Standards, 2002, Method M27-A2, Second Edition, Wayne, Pa Vol. 22 (15), pp 1-29
44. Method M-38A, Second Edition, Wayne, Pa Vol. 22 (16), pp 1-27. Amphotericin B (Sigma Chem. Co.), Ketoconazole (Janssen Pharmaceutica) and Terbinafine (Novartis) were used as standard antifungal drugs.