A gene-to-gene interaction between aromatase and estrogen receptors influences bone mineral density

European Journal of Endocrinology

Volumn 155, Issue 1, 2006, Pages 53-59

  Riancho, José A ^a   Zarrabeitia, María T ^a   Valero, Carmen ^a   Sañudo, Carolina ^a   Mijares, Verónica ^a   González Macías, Jesús ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; AROMATASE; CYTOSINE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GUANINE; THYMINE;

AGE; AGED; ALLELE; AROMATIZATION; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE TISSUE; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTROGEN SYNTHESIS; EXON; FEMALE; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HOMOZYGOSITY; HUMAN; HYPOTHESIS; INTRON; POSTMENOPAUSE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE; STATISTICAL ANALYSIS;

AGED; ALLELES; AROMATASE; BONE AND BONES; BONE DENSITY; DENSITOMETRY, X-RAY; DNA; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; EXONS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INTRONS; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; SPAIN;

EID: 33746276254     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02189     Document Type: Article

References (38)

1. Peacock M, Turner CH, Econs MJ & Foroud T. Genetics of osteoporosis. Endocrine Reviews 2002 23 303-326.
2. Ralston SH. Genetic control of susceptibility to osteoporosis. Journal of Clinical Endocrinology and Metabolism 2002 87 2460-2466.
3. Simpson ER & Davis SR. Aromatase and the regulation of estrogen biosynthesis-some new perspectives. Endocrinology 2001 142 4589-4594.
4. Kamat A, Hinshelwood MM, Murry BA & Mendelson CR. Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans. Trends in Endocrinology and Metabolism 2002 13 122-128.
5. Riancho JA, Zarrabeitia MT, Valero C, Sañudo C, Hernandez IL, Amado JA, Zarrabeitia A & Gonzalez-Macias J. Aromatase gene and osteoporosis: relationship of ten polymorphic loci with bone mineral density. Bone 2005 36 917-925.
6. Somner J, McLellan S, Cheung J, Mak YT, Frost ML, Knapp KM, Wierzbicki M, Fogelman I, Ralston SH & Hampson GN. Polymorphisms in the P450 c17(17-hydroxylase/17,20-lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2004 89 344-351.
7. Masi L, Becherini L, Gennari L, Amedei A, Colli E, Falchetti A, Farci M, Silvestri S, Gonnelli S & Brandi ML. Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk. Journal of Clinical Endocrinology and Metabolism 2001 86 2263-2269.
8. Zarrabeitia MT, Hernandez JL, Valero C, Zarrabeitia AL, Garcia-Unzueta MT, Amado JA, Gonzalez-Macias J & Riancho JA. A common polymorphism in the 5′-untranslated region of the aromatase gene influences bone mass and fracture risk. European Journal of Endocrinology 2004 150 699-704.
9. Gennari L, Merlotti D, De Paola V, Calabro A, Becherini L, Martini G & Nuti R. Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review. American Journal of Epidemiology 2005 161 307-320.
10. Herynk MH & Fuqua SAW. Estrogen receptor mutations in human disease. Endocrine Reviews 2004 25 869-898.
11. Koehler KF, Helguero LA, Haldosén LA, Warner M & Gustafsson JA. Reflections on the discovery and significance of estrogen receptor β. Endocrine Reviews 2005 26 465-478.
12. Docio S, Riancho JA, Perez A, Olmos JM, Amado JA & Gonzalez-Macias J. Seasonal deficiency of vitamin D in children: a potential target for osteoporosis-preventing strategies? Journal of Bone and Mineral Research 1998 13 544-548.
13. Katzman DK, Bachrach LK, Carter DR & Marcus R. Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. Journal of Clinical Endocrinology and Metabolism 1991 73 1332-1339.
14. Valero C, Zarrabeitia MT, Hernandez JL, Zarrabeitia MT, González-Macías J & Riancho JA. Bone mass in young adults: relationship with gender, weight, and genetic factors. Journal of Internal Medicine 2005 258 554-562.
15. Sano M, Inoue S, Hosoi T, Ouchi Y, Emi M, Shiraki M & Orimo H. Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis. Biochemical and Biophysical Research Communications 1995 217 378-383.
16. Schuit SC, Van Meurs JBJ, Bergink AP, Van der Klift M, Fang Y, Leusink G, Hofman A, van Leeuwen JPTM, Uitterlinden AG & Pols HAP. Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms. Journal of Clinical Endocrinology and Metabolism 2004 89 303-309.
17. Albagha OME, McGuigan FEA, Reid DM & Ralston SH. Estrogen receptor alpha gene polymorphisms and bone mineral density: haplotype analysis in women from the United Kingdom. Journal of Bone and Mineral Research 2001 16 128-134.
18. Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M & Orimo H. Association of bone mineral density with polymorphism of the estrogen receptor gene. Journal of Bone and Mineral Research 1996 11 306-311.
19. Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Piaseu N, Chailurkit L & Rjatanavin R. Association of a G2014A transition in exon 8 of the estrogen receptor-alpha gene with postmenopausal osteoporosis. Osteoporosis International 2001 12 1015-1019.
20. Ogawa S, Hosoi T Shiraki M, Orimo H, Emi M, Muramatsu M, Ouchi Y & Inoue S. Association of estrogen receptor β gene polymorphism with bone mineral density. Biochemical and Biophysical Research Communications 2000 269 537-541.
21. Scariano JK, Simplicio SG, Montoya GD, Garry PJ & Baumgartner RN. Estrogen receptor β dinucleotide (CA) repeat polymorphism is significantly associated with bone mineral density in postmenopausal women. Calcified Tissue International 2004 74 501-508.
22. Shearman AM, Karasik D, Gruenthal KM, Demissie S, Cupples LA, Housman DE & Kiel DP. Estrogen receptor β polymorphisms are associated with bone mass in women and men: The Framingham study. Journal of Bone and Mineral Research 2004 19 773-781.
23. Efstathiadou Z, Koukoulis G, Stakias N, Challa A, Zintzaras E & Tsatsoulis A. Correlation of estrogen receptor beta gene polymorphisms with spinal bone mineral density in peri- and postmenopausal Greek women. Maturitas 2006 53 380-385.
24. Ichikawa S, Koller DL, Peacock M, Johnson ML, Lai D, Hui SL, Johnston CC, Foroud TM & Econs MJ. Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women. Journal of Clinical Endocrinology and Metabolism 2005 90 5921-5927.
25. Lau HHL, Ho AYY, Luk KDK & Kung AWC. Estrogen receptor β gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women. Bone 2002 31 276-281.
26. Ongphiphadhanakul B, Chanprasertyothin S, Saetung S & Rajatanavin R. A specific haplotype in the 3′ end of estrogen-receptor alpha gene is associated with low bone mineral density in premenopausal women and increased risk of postmenopausal osteoporosis. Osteoporosis International 2005 16 1233-1238.
27. Ingles SA, Haile RW, Henderson BE, Kolonel LN, Nakaichi G, Shi CY, Yu MC, Ross RK & Coetzee GA. Strength of linkage disequilibrium between two vitamin D receptor markers in five ethnic groups: implications for association studies. Cancer Epidemiology, Biomarkers & Prevention 1997 6 93-98.
28. Long JR, Zhao LJ, Liu PY, Lu Y, Dvornyk V, Shen H, Liu YJ, Zhang YY, Xiong DH, Xiao P & Deng HW. Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. BMC Genetics 2004 5 11.
29. Ioannidis JP, Ralston SH, Bennett ST, Brandi ML, Grinberg D, Karassa FB, Langdahl B, van Meurs JB, Mosekilde L, Scollen S, Albagha OM, Bustamante M, Carey AH, Dunning AM, Enjuanes A, van Leeuwen JP, Mavilia C, Masi L, McGuigan FE, Nogues X, Pols HA, Reid DM, Schuit SC, Sherlock RE, Uitterlinden AG & GENOMOS Study. Differential genetics effects of ESR1 gene polymorphisms on osteoporosis outcomes. Journal of American Medical Association 2004 292 2105-2114.
30. Yim CH, Choi JT, Choi HA, Kang YS, Moon IG, Yoon HK, Han IK, Kang DH & Han KO. Association of estrogen receptor alpha gene microsatellite polymorphism with annual changes in bone mineral density in Korean women with hormone replacement therapy. Journal of Bone and Mineral Metabolism 2005 23 395-400.
31. Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Piaseu N, Chailurkit L, Chansirikarn S, Puavilai G & Rajatanavin R. Association of a T262C transition in exon 1 of estrogen-receptor-alpha gene with skeletal responsiveness to estrogen in post-menopausal women. Journal of Endocrinogical Investigation 2001 24 749-755.
32. Salmén T, Heikkinen AM, Mahonen A, Kroger H, Komulainen M, Saarikoski S, Honkanen R & Maenpaa PH. The protective effect of hormone-replacement therapy on fracture risk is modulated by estrogen receptor alpha genotype in early postmenopausal women. Journal of Bone and Mineral Research 2000 15 2479-2486.
33. Yahata T, Quan J, Tamura N, Nagata H, Kurabayashi T & Tanaka K. Association between single nucleotide polymorphisms of estrogen receptor alpha gene and efficacy of HRT on bone mineral density in post-menopausal Japanese women. Human Reproduction 2005 20 1860-1866.
34. Heilberg IP, Hernandez E, Alonzo E, Valera R, Ferreira LG, Gomes SA, Bellorin-Font E & Weisinger JR. Estrogen receptor (ER) gene polymorphism may predict the bone mineral density response to raloxifene in postmenopausal women on chronic hemodialysis. Renal Failure 2005 27 155-161.
35. Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA & Bleecker ER. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation 2002 105 1879-1882.
36. Herrington DM, Howard TD, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Brosnihan KB, Meyers DA & Bleecker ER. Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. New England Journal of Medicine 2002 346 967-974.
37. Onland-Moret NC, van Gils CH, Roest M, Grobbee DE & Peeters PH. The estrogen receptor alpha gene and breast cancer risk (The Netherlands). Cancer Causes Control 2005 16 1195-1202.
38. Fox CS, Yang Q, Cupples LA, Guo CY Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE & Shearman AM. Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. Journal of Clinical Endocrinology and Metabolism 2005 90 6257-6262.