Naturally occurring genetic variation in the age-specific immune response of Drosophila melanogaster

Aging Cell

Volumn 5, Issue 4, 2006, Pages 293-295

  Lesser, Karen J ^a,b   Paiusi, Ioana C ^a   Leips, Jeff ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Immunosenescence; Mutation accumulation; Natural population; Senescence

Indexed keywords

AGE; AGING; ARTICLE; CHROMOSOME SUBSTITUTION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FEMALE; GENE LOCUS; GENE MUTATION; GENETIC CORRELATION; GENETIC VARIABILITY; INNATE IMMUNITY; INSECT DEVELOPMENT; INSECT GENETICS; NONHUMAN; PHENOTYPIC VARIATION; PREDICTION; PRIORITY JOURNAL; SENESCENCE;

AGING; ANIMALS; DROSOPHILA MELANOGASTER; GENES, INSECT; IMMUNITY, NATURAL; VARIATION (GENETICS);

DROSOPHILA MELANOGASTER; ESCHERICHIA COLI;

EID: 33746274611     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2006.00219.x     Document Type: Article

References (19)

1. Bruunsgaard H, Pedersen AN, Schroll M, Skinhoj P, Pedersen BK (1999) Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans. Clin. Exp. Immunol. 118, 235-241.
2. Bruunsgaard H, Ladelund S, Pedersen AB, Schroll M, Jorgensen T, Pedersen BK (2003) Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin. Exp. Immunol. 132, 24-31.
3. Celniker SE, Rubin GM (2003) The Drosophila melanogaster genome. Annu. Rev. Genomics Hum. Genet. 4, 89-117.
4. Chakravarti B, Chakravarti DN, Devecis J, Seshi B, Abraham GN (1998) Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: Down-regulation of tyrosine phosphorylation of ZAP-70. Mech. Ageing Dev. 104, 41-58.
5. Charlesworth B, Hughes KA (1996) Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence. Proc. Natl Acad. Sci. USA 93, 6140-6145.
6. Cumberbatch M, Dearman RJ, Kimber I (2002) Influence of ageing on Langerhans cell migration in mice: Identification of a putative deficiency of epidermal interleukin-1β. Immunology 105, 466-477.
7. De Gregorio E, Spellman PT, Rubin GM, Lemaitre B (2001) Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc. Natl Acad. Sci. USA 98, 12590-12595.
8. De Luca M, Roshina NV, Geiger-Thornsberry GL, Lyman RF, Pasyukova EG, Mackay TFC (2003) Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. Nat Genet 34, 429-433.
9. Houle D (1992) Comparing evolvability and variability of quantitative traits. Genetics 130, 195-204.
10. Jamieson BD, Douek DC, Killian S, Hultin LE, Scripture-Adams DD, Giorgi JV, Marelli D, Koup RA, Zack JA (1999) Generation of functional thymocytes in the human adult. Immunity 10, 569-575.
11. Jin W, Riley RM, Wolfinger RD, White KP, Passador-Gurgel G, Gibson G (2001) The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Nat. Genet 29, 389-395.
12. Lazzaro BP, Sceurman BK, Clark AG (2004) Genetic basis of natural variation in D. melanogaster antibacterial immunity. Science 303, 1873-1876.
13. McKean KA, Nunney L (2001) Increased sexual activity reduces male immune function in Drosophila melanogaster. Proc. Natl Acad. Sci. USA 98, 7904-7909.
14. Medawar P (1952) An Unsolved Problem of Biology. London: H.K. Lewis.
15. Pletcher SD, Macdonald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB, Partridge L (2002) Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12, 712-723.
16. Robertson A (1959) The sampling variance of the genetic correlation coefficient. Biometrics 15, 469-485.
17. Strasser A, Teltscher A, May B, Sanders C, Niedermuller H (2000) Age-associated changes in the immune system of German shepherd dogs. J. Vet Med. A Physiol. Pathol. Clin. Med. 47, 181-192.
18. Zar J (1999) Biostatistical Analysis, 4th edn. Upper Saddle River, New Jersey: Prentice Hall.
19. Zerofsky M, Harel E, Silverman N, Tatar M (2005) Aging of the innate immune response in Drosophila melanogaster. Aging Cell 4, 103-108.