Coagulation activation and expression of CD40 ligand on platelets upon in vitro lipopolysaccharide-challenge in patients with unstable angina

International Journal of Cardiology

Volumn 111, Issue 2, 2006, Pages 217-223

  Kälsch, Thorsten ^a   Nguyen, Xuan Duc ^b   Elmas, Elif ^a   Grebert, Nadine ^a   Süselbeck, Tim ^c   Klüter, Harald ^b   Borggrefe, Martin ^a   Dempfle, Carl Erik ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c NONE

Author keywords

CD40L; Unstable angina; Whole blood coagulation

Indexed keywords

CD40 LIGAND; LIPOPOLYSACCHARIDE; PADGEM PROTEIN; THROMBOCYTE FACTOR 4; THROMBOPLASTIN;

ACUTE HEART INFARCTION; ANTIGEN EXPRESSION; ARTERIAL BLOOD; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; BLOOD LEVEL; BLOOD SAMPLING; BLOOD VISCOSITY; CARDIAC PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY THROMBOSIS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISCHEMIC HEART DISEASE; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROVOCATION TEST; STABLE ANGINA PECTORIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; UNSTABLE ANGINA PECTORIS; UPREGULATION; VISCOMETER;

AGED; ANGINA, UNSTABLE; BLOOD COAGULATION; BLOOD PLATELETS; CD40 LIGAND; CORONARY DISEASE; FEMALE; FLOW CYTOMETRY; HUMANS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; PROTHROMBIN TIME; TRIAZINES;

EID: 33746269460     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2005.08.001     Document Type: Article

References (35)

1. Libby P., Ridker P., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
2. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
3. Torzewski M., Rist C., Mortensen R., et al. C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb 20 (2000) 2094-2099
4. Zwaka T., Hombach V., and Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation 103 (2001) 1194-1197
5. Garlichs C.D., Eskafi S., Raaz D., et al. Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets. Heart 86 (2001) 649-655
6. Fichtlscherer S., Rosenberger G., Walter D.H., Breuer S., Dimmeler S., and Zeiher A.M. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102 (2000) 1000-1006
7. Buffon A., Biasucci L., Liuzzo G., D'Onofrio G., Crea F., and Maseri A. Widespread coronary inflammation in unstable angina. N Engl J Med 347 (2002) 5-12
8. Heeschen C., Dimmeler S., Hamm C.W., et al., the CAPTURE Study Investigators. Soluble CD40 ligand in acute coronary syndromes. N Engl J Med 348 (2003) 1104-1111
9. James S., Siegbahn A., Armstrong P., et al. Activation of the inflammation, coagulation, and fibrinolysis systems, without influence of abciximab infusion in patients with non-ST-elevation acute coronary syndromes treated with dalteparin: a GUSTO IV substudy. Am Heart J 147 (2004) 267-274
10. Albert C.M., Ma J., Rifai N., Stampfer M.J., and Ridker P.M. Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 105 (2002) 2595-2599
11. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., and Hennekens C.H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336 (1997) 973-979
12. Ridker P.M., Hennekens C.H., Buring J.E., and Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in woman. N Engl J Med 342 (2000) 836-843
13. Kahler J., Gerth S., Schafer P., et al. Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris. Am J Cardiol 87 (2001) 1150-1153
14. Liuzzo G., Angiolillo D.J., Buffon A., et al. Enhanced response of blood monocytes to in vitro lipopolysaccharide-challenge in patients with recurrent unstable angina. Circulation 103 (2001) 2236-2241
15. Danesh J., Whincup P., Walker M., et al. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ 321 (2000) 199-204
16. Varo N., de Lemos J.A., Libby P., et al. Soluble CD40L: risk prediction after acute coronary syndromes. Circulation 108 (2003) 1049-1052
17. Derhaschnig U., Reiter R., Knobl P., Baumgartner M., Keen P., and Jilma B. Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia. Blood 102 (2003) 2093-2098
18. Yee S.B., Hanumegowda U.M., Copple B.L., Shibuya M., Ganey P.E., and Roth R.A. Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure. Toxicol Sci 74 (2003) 203-214
19. Asakura H.S.Y., Yoshida T., Ontachi Y., et al. Pathophysiology of disseminated intravascular coagulation (DIC) progresses at a different rate in tissue factor-induced and lipopolysaccharide-induced DIC models in rats. Blood Coagul Fibrinolysis 14 (2003) 221-228
20. Van Deventer S.J., Buller H.R., ten Cate J.W., Sturk A., and Pauw W. Endotoxinaemia: an early predictor of septicaemia in febrile patients. Lancet 1 (1988) 605-609
21. Ranby M., Ramstrom S., Svensson P.O.., and Lindahl T.L. Clotting time by free oscillation rheometry and visual inspection and a viscoelastic description of the clotting phenomenon. Scand J Clin Lab Invest 63 6 (2003) 397-406
22. Harb T.S., Zareba W., Moss A.J., et al., THROMBO Investigators. Association between inflammatory markers, hemostatic, and lipid factors in postinfarction patients. Am J Cardiol 91 (20031) 1120-1123
23. Burke A.P., Tracy R.P., Kolodgie F., et al. Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies. Circulation 105 (2002) 2019-2023
24. Liuzzo G., Biasucci L., Gallimore J.R., et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 331 (1994) 417-424
25. Toss H., Lindahl B., Siegbahn A., and Wallentin L. Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. FRISC Study Group. Fragmin during instability in coronary artery disease. Circulation 96 (1997) 204-4210
26. Kälsch T., Elmas E., Nguyen X.D., et al. Enhanced coagulation activation by in vitro lipopolysaccharide challenge in patients with ventricular fibrillation complicating acute myocardial infarction. J Cardiovasc Electrophysiol 16 8 (2005 (Aug)) 858-863
27. Kälsch T, Elmas E, Nguyen XD, et al. Enhanced expression of platelet CD40-ligand by in vitro lipopolysaccharide-challenge in patients with ventricular fibrillation complicating acute myocardial infarction. Int J Cardiol; in press. doi:10.1016/j.ijcard.2005.03.047.
28. Patel P.B., Pfau S.E., Cleman M.W., et al. Comparison of coronary artery specific leukocyte-platelet conjugate formation in unstable versus stable angina pectoris. Am J Cardiol 93 (2004) 410-413
29. Golino P., Ravera A., Ragni M., Cirillo P., Piro O., and Chiariello M. Involvement of tissue factor pathway inhibitor in the coronary circulation of patients with acute coronary syndromes. Circulation 108 (2003) 2864-2869
30. Garlichs C.D., John S., Schmeisser A., et al. Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia. Circulation 104 (20012) 2395-2400
31. May A.E., Kälsch T., Massberg S., Herouy Y., Schmidt R., and Gawaz M. Engagement of glycoprotein IIb/IIIa ({alpha}IIb{beta}3) on platelets upregulates CD40l and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation 106 (2002) 2111-2117
32. Inwald D.P., McDowall A., Peters M.J., Callard R.E., and Klein N.J. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res 92 (2003) 1041-1048
33. Schönbeck U., Sukhova G., Shimizu K., Mach F., and Libby P. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proc Natl Acad Sci U S A 97 (2000) 7458-7463
34. Mach F., Schonbeck U., Sukhova G., Atkinson E., and Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 394 (1998) 200-2003
35. Henn V., Slupsky J., Grafe M., et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391 (1998) 591-594