Pharmacology meets vesicular trafficking at a central nervous system synapse: Pregabalin effects on synaptic vesicle cycling in hippocampal neurons

Molecular Pharmacology

Volumn 70, Issue 2, 2006, Pages 444-446

  Holz, Ronald W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PREGABALIN;

CELL CULTURE; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; EXOCYTOSIS; HIPPOCAMPUS; HUMAN; NERVE CELL; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; SHORT SURVEY; SYNAPSE VESICLE;

BIOLOGICAL TRANSPORT; CALCIUM; EXOCYTOSIS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; NEURONS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC VESICLES;

EID: 33746265827     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.026914     Document Type: Short Survey

References (11)

1. Betz WJ and Bewick GS (1992) Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction. Science (Wash DC) 255:200-203.
2. Gong HC, Hang J, Kohler W, Li L, and Su TZ (2001) Tissue-specific expression and gabapentin-binding properties of calcium channel A2δ subunit subtypes. J Membrane Biol 184:35-43.
3. Holz RW and Fisher SK (2006) Synaptic transmission and cellular signaling: an overview, in Basic Neurochemistry, 7th ed (Siegel GJ, Albers RW, Brady ST, and Price DL eds) pp 167-183, Elsevier Academic Press, San Diego.
4. MacDermott AB, Role LW, and Siegelbaum SA (1999) Presynaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci 22:443-485.
5. Micheva KD, Buchanan J, Holz RW, and Smith SJ (2003) Retrograde regulation of synaptic vesicle endocytosis and recycling. Nat Neurosci 6:925-932.
6. Micheva KD and Smith SJ (2005) Strong effects of subphysiological temperature on the function and plasticity of mammalian presynaptic terminals. J Neurosci 25:7481-7488.
7. Micheva KD, Taylor CP, and Smith SJ (2006) Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol 70:467-476.
8. Murthy VN, Schikorski T, Stevens CF, and Zhu Y (2001) Inactivity produces increases in neurotransmitter release and synapse size. Neuron 32:673-682.
9. Piechan JL, Donevan SD, Taylor CP, Dickerson MR, and Li Z (2004) Pregabalin, a novel anticonvulsant, analgesic and anxiolytic drug, exhibits class-specifric Α2δ-1 and Α2δ-2 calcium channel subunit binding. Soc Neurosci Abstr 30:115.11.
10. Rizzoli SO and Betz WJ (2005) Synaptic vesicle pools. Nat Rev Neurosci 6:57-69.
11. Rosenmund C and Stevens CF (1996) Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16:1197-1207.