Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors

Molecular Diversity

Volumn 10, Issue 2, 2006, Pages 223-231

  Khan, Khalid Mohammed ^a   Ullah, Zia ^a   Lodhi, Muhammad Arif ^a   Ali, Muhammad ^a   Choudhary, Muhammad Iqbal ^a   Rahman, Atta Ur ^a   Haq, Zaheer Ul ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

(4R) thiazolidine carboxylic acid; Computer guided synthesis; Urease inhibitors

Indexed keywords

TIMONACIC; UREASE INHIBITOR;

ALGORITHM; ARTICLE; CHEMICAL STRUCTURE; COMPUTER ANALYSIS; DATA BASE; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; SCREENING; SYNTHESIS;

COMPUTER-AIDED DESIGN; DATABASES, FACTUAL; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; THIAZOLES; THIAZOLIDINES; UREASE;

EID: 33746238236     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11030-005-9000-6     Document Type: Article

References (14)

1. Mobley, H.L.T. and Hausinger, R.P., Microbial ureases: significance, regulation, and molecular characterization, Microbiol. Rev., 53 (1989) 85-108.
2. Zonia, L.E., Stebbins, N.E. and Polacco, J.C., Essential role of urease in germination of nitrogen-limited arabidopsis thaliana seeds, Plant Physiol., 107 (1995) 1097-1103.
3. Mulvaney, R.L. and Bremner, J.M., in Soil Biochemistry (Paul, E.A., and Ladd, J.N., Eds.), Marcel Dekker, Inc., New York (1981) 153-196.
4. Mobley, H.L.T., Island, M.D. and Hausinger, R.P., Molecular biology of microbial ureases, Microbiol. Rev., 59 (1995) 451-480.
5. Bayerdorffer, E. and Ottenjhan, R., The Role of antibiotics in the campylobacter pylori associated peptic ulcer disease. Scand. J. Gastroenterol., 23 (1988) 93-100.
6. Jain A.N., Virtual screening in lead discovery and optimization, Curr. Opin. Drug. Discov. Devel., 7 (2004) 396-403.
7. Verdonk N.I., Strategy of computer-aided drug design, Curr. Drug Targets Infect. Disord., 3 (2003) 33-40.
8. Goodford, P.J., A computational procedure for determining energetically favorable binding sites on biologically important molecules, J. Med. Chem., 28 (1985) 849-857.
9. SYBYL molecular modeling software. Tripos Associated Ltd. St. Louis MO.
10. Quinn, M., Acetylcholinesterase: enzyme structure, reaction. Dynamics, and virtual transition states, Chem. Rev., 87 (1987) 955-979.
11. Massoulie, J., Pezzementi, L., Bon, S., Krejci, E. and Vallette, F.M., Molecular and cellular biology of cholinesterases, Prog. Neurobiol., 41 (1993) 31-91.
12. Weatherburn, M.W. Phenol-hypochlorite reaction for determination of ammonia, Anal. Chem., 39 (1967) 971-974.
13. McLaughlin, J.L., Chang, C.-J. and Smith, D.L., in Studies in Natural Products Chemistry, "Bentch-Top" Bioassays for the Discovery of Bioactive Natural Products: an update, Structure and Chemistry, part-B, (Atta-ur-Rahman, Ed.) Elsevier Science Publishers B.V., The Netherlands, Vol. 9 (1991) 38;
14. (b) Meyer, B.N.; Ferrigni, N.R.; Putnam, J.E.; Jacobsen, L.B.; Nichols, D.E.; McLaughlin, J.L. Brine shrimp: a convenient general bioassay for active plant constituents, Planta Medica, 45 (1982) 31.