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Schulze PC, Fang J, Kassik KA, et al. Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ Res 2005; 97:418-426. This paper suggests that transgenic expression of IGF-1 in atrophied skeletal muscle may offer benefit in muscle wasting occurring as a result of ischemic cardiomyopathy.
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Circ Res
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Schulze, P.C.1
Fang, J.2
Kassik, K.A.3
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56
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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
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U S A
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Sjogren K, Liu JL, Blad K, et al. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci U S A 1999; 96:7088-7092.
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Proc Natl Acad Sci
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Sjogren, K.1
Liu, J.L.2
Blad, K.3
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57
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Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation
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Song YH, Godard M, Li Y, et al. Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation. J Investig Med 2005; 53:135-142. This paper analyses the phosphoprotein profile of skeletal muscle in muscle-specific IGF-1 transgenic mice.
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(2005)
J Investig Med
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, pp. 135-142
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Song, Y.H.1
Godard, M.2
Li, Y.3
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58
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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
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Stitt TN, Drujan D, Clarke BA, et al. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 2004; 14:395-403. The authors demonstrate that IGF-1 inhibits ubiquitin ligase expression in atrophied muscle via FOXO transcription factors.
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(2004)
Mol Cell
, vol.14
, pp. 395-403
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Stitt, T.N.1
Drujan, D.2
Clarke, B.A.3
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59
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85047693596
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Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions
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Du J, Wang X, Miereles C, et al. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 2004; 113:115-123. These authors demonstrate that activated caspase-3 can degrade actin and that this is an initial critical step leading to increased muscle proteolysis.
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J Clin Invest
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, pp. 115-123
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Du, J.1
Wang, X.2
Miereles, C.3
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60
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Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase
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Tintignac LA, Lagirand J, Batonnet S, et al. Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase. J Biol Chem 2005; 280:2847-2856. This paper demonstrates that MyoD is regulated by Atrogin-1 /MAFbx in atrophying muscle.
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(2005)
J Biol Chem
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, pp. 2847-2856
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Tintignac, L.A.1
Lagirand, J.2
Batonnet, S.3
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61
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Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway
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Latres E, Amini AR, Amini AA, et al. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 2005; 280:2737-2744. The authors characterize the IGF-1/PI3K/Akt signaling pathway in anabolic (hypertrophic) and catabolic (atrophic) conditions.
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(2005)
J Biol Chem
, vol.280
, pp. 2737-2744
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Latres, E.1
Amini, A.R.2
Amini, A.A.3
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