Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study

International Journal of Oral and Maxillofacial Surgery

Volumn 35, Issue 9, 2006, Pages 791-795

  de Lange, J ^a   van den Akker, H P ^a   Veldhuijzen van Zanten, G O ^b   Engelshove, H A ^b   van den Berg, H ^c   Klip, H ^d  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Sittard Geleen Heerlen   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d Research Bureau   (Netherlands)

Author keywords

calcitonin; central giant cell granuloma; interferon alpha; therapy

Indexed keywords

CALCIUM; PARATHYROID HORMONE; PLACEBO; SALCATONIN;

ADOLESCENT; ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG RESPONSE; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPISTAXIS; FEMALE; FLUSHING; FOLLOW UP; GIANT CELL GRANULOMA; HISTOLOGY; HUMAN; HUMAN TISSUE; JAW TUMOR; MALE; NAUSEA; PARATHYROID HORMONE BLOOD LEVEL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TUMOR REGRESSION; TUMOR VOLUME;

ADOLESCENT; ADULT; BONE DENSITY CONSERVATION AGENTS; CALCITONIN; CHI-SQUARE DISTRIBUTION; CHILD; DOUBLE-BLIND METHOD; FEMALE; GRANULOMA, GIANT CELL; HUMANS; JAW DISEASES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 33746205306     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijom.2006.03.030     Document Type: Article

References (20)

1. Azria M. The Calcitonin, Physiology and Pharmacology (1989), Karger, London
2. Chambers T.J., Fuller K., and McSheeny P.M.J. The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells. J Pathol 45 (1985) 297-305
3. Chuong R., Kaban L.B., Kozakewich H., and Perez-Atayde A. Central giant cell lesions of the jaws; A clinicopathologic study. J Oral Maxillofac Surg 44 (1986) 708-713
4. Dominguez Cuadrado L., Martinez Gimeno C., Plasencia Delgado J., and Suner M. Intranasal calcitonin therapy for central giant cell granuloma. J Craniomaxillofac Surg 32 Suppl. 1 (2004) 244-245
5. Flanagan A.M., Tinkler S.M.B., Horton M.A., Williams D.M., and Chambers T.J. The multinucleate cells in the giant cell granulomas of the jaw are osteoclasts. Cancer 62 (1988) 1139-1145
6. Harris M. Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg 31 (1993) 89-94
7. Itonaga I., Hussein I., Kudo O., Sabokbar A., Watt-Smith S., Ferguson D., and Athanasou N.A. Cellular mechanisms of osteoclast formation and lacunar resorption in giant cell granuloma of the jaw. J Oral Pathol Med 32 (2003) 224-231
8. Itonaga I., Schulze E., Burge P.D., Gibbons C.L.M.H., Ferguson D., and Athanasou N.A. Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones. J Pathol 198 (2002) 30-36
9. Kaban L.B., Troulis M.J., Ebb D., August M., Hornicek F.J., and Dodson T.B. Antiangiogenetic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg 60 (2002) 1103-1111
10. de Lange J., Rosenberg A.J.W.P., van den Akker H.P., Koole R., Wirds J.J., and van den Berg H. Treatment of central giant cell granuloma of the jaw with calcitonin. Int J Oral Maxillofac Surg 28 (1999) 372-376
11. de Lange J., van den Akker H.P., and Klip H. Incidence and disease-free survival after surgical therapy of central giant-cell granulomas of the jaw in The Netherlands: 1990-1995. Head Neck 26 (2004) 792-795
12. Lerner U.H. New molecules in the tumor necrosis factor ligand and receptor superfamilies with importance for physiological and pathological bone resorption. Crit Rev Oral Biol Med. 15 (2004) 64-81
13. Lui B., Yu S.-F., and Li T.-J. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med 32 (2003) 367-375
14. Miyamoto N., Higuchi Y., Tajima M., Ito M., Tsurudome M., Nishio M., Kawano M., Sudo A., Uchida A., and Ito Y. Spindle-shaped cells derived from giant-cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells. J Orthop Res 18 (2000) 647-654
15. Nagasawa T., Kobayashi H., Kiji M., Aramaki M., Mahanonda R., Kojima T., Murakami Y., Saito M., Morotome Y., and Ishikawa I. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin Exp Immunol 130 (2002) 338-344
16. O'Malley M., Pogrel M.A., Stewart J.C.B., Silva R.G., and Regezi J.A. Central giant cell granulomas of the jaws: phenotype and proliferation associated markers. J Oral Pathol Med 26 (1997) 159-163
17. O'Regan E.M., Gibb D.H., and Odell E.W. Rapid growth of giant cell granuloma in pregnancy treated with calcitonin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92 (2001) 532-538
18. Pogrel M.A. Calcitonin therapy for central giant cell granuloma. J Oral Maxillofac Surg 61 (2003) 649-653
19. Pogrel M.A., Regezi J.A., Harris S.T., and Goldring S.R. Calcitonin treatment for central giant cell granulomas of the mandible: Report of two cases. J Oral Maxillofac Surg 57 (1999) 848-853
20. Tiffee J.C., and Aufdemorte T.B. Markers for marcrophage and osteoclast lineages in giant cell lesions of the oral cavity. J Oral Maxillofac Surg 55 (1997) 1108-1112