Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: A retrospective study focused on the aggression and negativism in care-giving situations

Brain and Nerve

Volumn 58, Issue 6, 2006, Pages 483-488

  Kitamura, Yoko ^a   Kudo, Yuri ^a   Imamura, Toru ^a,b,c  

^a NIIGATA UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b Niigata Rehabilitation Hospital   (Japan)

^c School of Health Sciences   (Japan)

Author keywords

Aggression; Alzheimer's disease; Behavioral and psychological symptoms of dementia (Bpsd); Negativism; Trazodone

Indexed keywords

ANTIDEPRESSANT AGENT; DONEPEZIL; FLUVOXAMINE; HALOPERIDOL; RILMAZAFONE; TIAPRIDE; TRAZODONE; ZOPICLONE;

AGED; ALZHEIMER DISEASE; ARTICLE; BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA; CAREGIVER BURDEN; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DAILY LIFE ACTIVITY; FATIGUE; FEMALE; HUMAN; MALE; MEDICAL RECORD; PATIENT CARE; URINE INCONTINENCE;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; AGGRESSION; ALZHEIMER DISEASE; ANTI-ANXIETY AGENTS; BEHAVIOR; CAREGIVERS; DEMENTIA; FEMALE; HUMANS; MALE; NEGATIVISM; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; RETROSPECTIVE STUDIES; TRAZODONE; TREATMENT OUTCOME;

EID: 33746185490     PISSN: 00068969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. American Psychiatric Association: Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. American Psychiatric Association, Washington D.C., 1997
2. Cohen-Mansfield J, Marx MS, Rosenthal AS: A description of agitation in a nursing home. J Gerontol Med Sci 44: M77-84, 1989
3. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J: The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44: 2308-2314, 1994
4. Finkel SI, Silva JC, Cohen G, Miller S, Sartorius N: Consensus statement behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 8: Suppl 3, 1996
5. Folstein MF, Folstein SE, McHugh PR: "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198, 1975
6. Neuropsychiatric Inventory 49: 266-271, 1997
7. Houliham DJ, Mulsant BH, Sweet RA, Rifai AH, Pasternak R, Rosen J, Zubenko GS: A naturalistic study of trazodone in the treatment of behavioral complications of dementia. Am J Geriatr Psychiatry 2: 78-85, 1994
8. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 140: 566-572, 1982
9. Lebert F, Pasquire F, Petit H: Behavioral effects of trazodone in Alzheimer's disease. J Clin Psychiatry 55: 536-538, 1994
10. Lebert F, Stekke W, Hasenbroekx C, Pasquier F: Frontotemporal dementia: a randmised, controlled trial with trazodone. Dement Geriatr Cogn Disord 17: 355-359, 2004
11. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944, 1984
12. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Fronto-temporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51: 1546-1554, 1998
13. Smith DA: New Directions in Geriatric Psychophamacology. Manisses Communication Group, Providence, 2000
14. Stahl SM: Essental Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press, Cambridge, 1996
15. Sultzer DL, Kevin FG, Gunay I, Berisford MA, Machael ME: A double-blind comparison of trazodone and haloperidol for treatment of agitation in patient with dementia. Am J Geriatr Psychiatry 5: 60-69, 1997
16. Sultzer DL, Gray KF, Gunay I, Wheatley MV, Mahler ME: Dose behavioral improvement with haloperidol or trazodone treatment depend on psychosis or mood symptoms in patient with dementia? J Am Geriatr Soc 49: 1294-1300, 2001
17. Ten L, Logsgon RG, Peskind E, Raskind M, Weiner MF, Tractenberg RE, Foster NL, Schneider LS, Sano M, Whitehouse P, Tariot P, Mellow AM, Auchus AP, Grundmam M, Thomas RG, Schafer K, Thal LJ: Treatment of agitation in AD: a randomized placebo-controlled clinical trial. Neurology 55: 1271-1278, 2000