In vivo antimalarial and cytotoxic properties of Annona senegalensis extract

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 3, Issue 1, 2006, Pages 137-141

  Ajaiyeoba, Edith ^a   Falade, Mofolusho ^a   Ogbole, Omonike ^b   Okpako, Larry ^c   Akinboye, Dora ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b OLABISI ONABANJO UNIVERSITY   (Nigeria)

^c NATIONAL INSTITUTE FOR PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (Nigeria)

Author keywords

Annona senegalensis; Cytotoxicity; Mice antimalarial; Plasmodium berghei

Indexed keywords

ALKALOID; ANNONA SENEGALENSIS EXTRACT; ANTIMALARIAL AGENT; CARDIAC GLYCOSIDE; CHLOROQUINE; PLACEBO; PLANT EXTRACT; SAPONIN; SODIUM CHLORIDE; TANNIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANNONA SENEGALENSIS; ANNONACEAE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DETERMINATION; DRUG POTENCY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MALE; MOUSE; NONHUMAN; PARASITEMIA; PLANT LEAF; PLASMODIUM BERGHEI; STATISTICAL SIGNIFICANCE;

EID: 33746174181     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Andrade-Neto, V. F., Brandao, M.G. L., Stehmann, J. R., Oliveira, L. A. and Krettli, A. U. (2003). Antimalarial activity of Cinchona- like plants used to treat fever and malaria in Brazil. J. Ethnopharmacol. 87: 253-256.
2. Agbaje, E.O. and Onabanjo, A.O. (1991). The Effects of extracts of Enantia chlorantha in malaria. Ann. Trop. Med. Parasitol. 85:585-590.
3. Butler, D. (1997). Time to put malaria control on the global agenda. Nature 386: 535-536.
4. De Sã Ferrira, I. C. F. and Ferrão Vargas, V. M. (1999). Mutagenicity of medicinal plant extracts in salmonella/microsome assay. Phytother. Res. 13: 397-400.
5. Fabricant, D. S. and Farnsworth, N. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives 109: 69-75.
6. Gbeassor, M., Kedjagni, A.Y., Koumaglo, de Souza, C., Agbo, K., Aklikokou, K. and Amegbo, D. A. (1990). In vitro antimalarial activity of six medicinal plants. Phytother. Res. 4 (3): 115-117.
7. Geoffrey, P. (1998). The treatment of Falciparum malaria in African children. African Health 20: 19-20.
8. Gessler, M. C., Nkunya, M. H. H., Mwasunmbi, L. B., Heinrich, M. and Tanner, M. (1994). Screening Tanzanian medicinal plants for antimalarial activity. Acta Trop. 56:65-77.
9. Le Tran, Q., Tezuka, Y., Ueda, J., Nguyen, N. T., Maruyama, Y., Begum, K., Kim, H.S., Wataya, Y., Tran, Q.K. and Kadota, S. (2003). In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. J. Ethnopharmacol. 86: 249-252.
10. McBrien, K. D., Bery, R. L., Lewes, S.E., Nedderman, K. M., Bursuker, I., Huang, S., Wehr, S. E. and Leet, J. E. (1995). Rakicidins, a new cytotoxic lipopeptide from Micromonospora sp. fermentation, isolation and characterization. J. Antibiot. 48: 1446-1452.
11. Muregi, F. W., Chhabra, S. C., Njagi, E. N. M., Lang'at-Thoruwa, C. C., Njue, W. M., Orago, A. S. S., Omar, S. A. and Ndiege, I. O. (2003). In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects. J. Ethnopharmacol. 84: 235-239.
12. Perez, H. A., De la Rosa, M. and Apitz, R. (1994). In vivo activity of ajoene against rodent malaria. Antimicrob. Agents Chemother. 38: 337-339.
13. Peters, W., 1965 Drug resistance in Plasmodium berghei I. Chloroquine resistance. Exptl. Parasitol. 17: 80-89.
14. Rupprecht, J. K, Hui, Y. H. and McLaughlin, J. L. (1990). Annonaceous acetogenins: a review. Journal of Natural Products 53(2): 237-278.
15. Schimmer, O., Kruger, A., Paulini, H. and Haefele, F. (1994). An evaluation of 55 commercial plant extracts in the Ames mutagenicity test. Pharmazie 49: 448-451.
16. Sofowora, E. A (1993). Medicinal plants and traditional medicine in Africa, 2nd edition, P. 85,174, 195-198.