New cathepsin D inhibitors with hydroxyethylamine isosteres: Preparation and characterization

Medicinal Chemistry

Volumn 2, Issue 1, 2006, Pages 27-38

  McConnell, R M ^a   Green, A W ^a   Trana, C J ^a   McConnell, M S ^a   Lindley, J F ^a   Sayyar, K ^a   Godwin, W E ^a   Hatfield, S E ^b  

^a UNIVERSITY OF ARKANSAS   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

BOC protecting group; Column chromatography; Combinatorial library; HIV 1 protease; N phenylpiperazine; NMR

Indexed keywords

3 (ACETYLALANYLPHENYLALANYLAMINO) 4 PHENYL 1 N (PROLINE METHYL ESTER) 2 BUTANOL; 3 (ACETYLALANYLPHENYLALANYLAMINO) 4 PHENYL 1 N MORPHOLINE 2 BUTANOL; 3 (ACETYLALANYLPHENYLALANYLAMINO) 4 PHENYL 1 N PIPERAZINE 2 BUTANOL; 3 (ACETYLLEUCYLLEUCYLAMINO) 4 PHENYL 1 N (LEVO PIPERAZINE 2 CARBOXYLIC METHYL ESTER) 2 BUTANOL; 3 (ACETYLLEUCYLLEUCYLAMINO) 4 PHENYL 1 N (PROLINE METHYL ESTER) 2 BUTANOL; 3 (ACETYLLEUCYLLEUCYLAMINO) 4 PHENYL 1 N MORPHOLINE 3 BUTANOL; 3 (ACETYLLEUCYLLEUCYLAMINO) 4 PHENYL 1 N PIPERAZINE 2 BUTANOL; 3 (ACETYLLEUCYLPHENYLALANYLAMINO) 4 PHENYL 1 N (LEVO PIPERAZINE 2 CARBOXYLIC METHYL ESTER) 2 BUTANOL; 3 (ACETYLLEUCYLPHENYLALANYLAMINO) 4 PHENYL 1 N (PROLINE METHYL ESTER) 2 BUTANOL; 3 (ACETYLLEUCYLPHENYLALANYLAMINO) 4 PHENYL 1 N MORPHOLINE 2 BUTANOL; 3 (ACETYLLEUCYLPHENYLALANYLAMINO) 4 PHENYL 1 N PIPERAZINE 2 BUTANOL; 3 (ACETYLVALYLPHENYLALANYLAMINO) 4 PHENYL 1 N (LEVO PIPERAZINE 2 CARBOXYLIC METHYL ESTER) 2 BUTANOL; 3 (ACETYLVALYLPHENYLALANYLAMINO) 4 PHENYL 1 N (PROLINE METHYL ESTER) 2 BUTANOL; 3 (ACETYLVALYLPHENYLALANYLAMINO) 4 PHENYL 1 N MORPHOLINE 2 BUTANOL; 3 (ACETYLVALYLPHENYLALANYLAMINO) 4 PHENYL 1 N PIPERAZINE 2 BUTANOL; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; BUTANOL; CARBOXYLIC ACID; CATHEPSIN D; CATHEPSIN D INHIBITOR; ESTER DERIVATIVE; ETHANOLAMINE; MORPHOLINE; PIPERAZINE; PIPERAZINE DERIVATIVE; PROLINE; PROTEINASE INHIBITOR; TERTIARY AMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ARTICLE; CANCER CELL; COLON CANCER; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME RELEASE; EXTRACELLULAR MATRIX; IC 50; METASTASIS POTENTIAL; OVARY CANCER; PATHOGENESIS; PRIORITY JOURNAL; PROSTATE CANCER; UTERUS CANCER;

ALZHEIMER DISEASE; ANTINEOPLASTIC AGENTS; ASPARTIC ENDOPEPTIDASES; CARBOXYLIC ACIDS; CATHEPSIN D; ESTERS; ETHYLAMINES; EXTRACELLULAR MATRIX; FEMALE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MALE; NEOPLASMS; PIPERAZINES; PROTEASE INHIBITORS; TUMOR CELLS, CULTURED;

EID: 33746147381     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606775197705     Document Type: Article

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