Single-day famciclovir therapy for recurrent genital herpes

Current Medical Research and Opinion

Volumn 22, Issue 7, 2006, Pages 1307-1310

  Whitley, Richard ^a   Diaz Mitoma, Francisco ^b   Hamed, Kamal ^c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antiviral; Famciclovir; Genital herpes; Patient initiated episodic therapy; Single day therapy

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; FAMCICLOVIR; NUCLEOSIDE ANALOG; PENCICLOVIR; VALACICLOVIR;

CLINICAL TRIAL; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DOSE REGIMEN; GENITAL HERPES; HUMAN; RECURRENT INFECTION; REVIEW; UNSPECIFIED SIDE EFFECT; VIRUS INFECTION; VIRUS REPLICATION;

2-AMINOPURINE; ADMINISTRATION, ORAL; ANTIVIRAL AGENTS; HERPES GENITALIS; HUMANS; RECURRENCE;

EID: 33746142131     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079906X112642     Document Type: Review

References (20)

1. Fleming DT, McQuillian GM, Johnson RE, et al. Herpes simplex virus type 2 in the United States, 1976-1994. New Engl J Med 1997;337:1105-11
2. Malkin JE. Epidemiology of genital herpes simplex virus infection in developed countries. Herpes 2004;11(Suppl 1):2A-23A
3. Apoola A, Radcilffe K. Antiviral treatment of genital herpes. Int J STD AIDS 2004;15:429-33
4. Barton SE, Ebel CE, Kirchner JT, Mertz GJ. The clinical management of recurrent genital herpes: current issues and future prospects. Herpes 2002;9:15-20
5. Drob S, Loemer M, Lifshutz H. Genital herpes: the psychological consequences. Br J Med Psychol 1985;58:307-15
6. Freeman EE, Weiss HA, Glynn JR, et al. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 2006;20:73-83
7. Brown ZA, Kern ER, Spruance SL, Overall Jr JC. Clinical and virologic course of herpes simplex genitalis. West J Med 1979;130:414-21
8. Spruance SL. Herpes simplex labialis. In: Sacks SL, Straus SE, Whitley RJ, Griffiths PD, editors. Clinical management of herpes viruses. Amsterdam, Netherlands: IOS Press, 1995; p.3-42
9. Aoki FY, Tyring S, Diaz-Mitoma F, et al. Single-day, patient-initiated famciclovir therapy for recurrent genital herpes: a randomized, double blind, placebo-controlled trial. Clin Infect Dis 2006;42:8-13
10. Diaz-Mitoma F, Sibbald G, Shafran SD, et al. Oral famciclovir for the suppression of recurrent genital herpes. A randomized controlled trial. J Am Med Assoc 1998;280:887-92
11. Reitano M, Tyring S, Lang W, et al. Valaciclovir for the suppression of recurrent genital herpes simplex virus infection: a large-scale dose range-finding study. J Infect Dis 1998;178:603-10
12. Corey L, Wald A, Patel R, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. New Engl J Med 2004;350:11-20
13. Reichman RC, Badger GJ, Guinan ME, et al. Topically administered acyclovir in the treatment of recurrent herpes simplex genitalis: a controlled trial. J Infect Dis 1983;147:336-40
14. Reichman RC, Badger GJ, Mertz GJ, et al. Treatment of recurrent genital herpes simplex infections with oral acyclovir. A controlled trial. J Am Med Assoc 1984;251:2103-7
15. Wald A, Carrell D, Remington M, et al. Two-day regimen of acyclovir for treatment of recurrent genital herpes simplex virus type 2 infection. Clin Infect Dis 2002;34:944-8
16. Valtrex package insert. GlaxoSmithKline, Research Triangle Park, NC. 2005
17. Tyring SK, Douglas Jr JM, Corey L, et al. A randomized, placebo-controlled comparison of oral valacyclovir and acyclovir in immunocompetent patients with recurrent genital herpes infections [The Valaciclovir International Study Group]. Arch Dermatol 1998;134:185-91
18. Leone PA, Trottier S, Miller JM. Valacyclovir for episodic treatment of genital herpes: a shorter 3-day treatment course compared with 5-day treatment. Clin Infect Dis 2002;34:958-62
19. Pue MA, Benet MA. Pharmacokinetics of famciclovir in man. Antivir Chem Chemother 1993;4(Suppl 1):47-55
20. Sacks S, Aoki F, Diaz-Mitoma F, et al. Patient-initiated, twice-daily oral famciclovir for early recurrent genital herpes. J Am Med Assoc 1996;276:44-9