Vesicoureteric Reflux in Children

EAU-EBU Update Series

Volumn 4, Issue 4, 2006, Pages 129-140

  Ismaili, Khalid ^a   Avni, Fred E ^b   Piepsz, Amy ^c   Collier, Frank ^a   Schulman, Claude ^b   Hall, Michelle ^a  

^a HOP UNIV DES ENFANTS REINE FABIOLA   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Fetal hydronephrosis; Radionuclide cystography; Ultrasonography; Urinary tract infection; Voiding cystourethrography

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; BULKING AGENT; CEFACLOR; COLLAGEN; COTRIMOXAZOLE; DEXTRANOMER; HYALURONIC ACID; NITROFURANTOIN; POLITEF; POLYMER; POLYMETHYLSILOXANE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANTIBIOTIC THERAPY; ANTIREFLUX OPERATION; AUTOSOMAL DOMINANT INHERITANCE; CARTILAGE CELL; CHILD; CHILDHOOD DISEASE; CHRONIC KIDNEY FAILURE; CIRCUMCISION; CLINICAL TRIAL; CYSTOGRAPHY; DISEASE ASSOCIATION; ECHOGRAPHY; ENDOSCOPIC THERAPY; FAMILIAL DISEASE; HUMAN; HYPERTENSION; INFECTION RISK; KIDNEY DISEASE; KIDNEY PARENCHYMA; META ANALYSIS; MICTURITION CYSTOURETHROGRAPHY; MICTURITION DISORDER; OUTCOMES RESEARCH; PEDIATRICS; RECURRENCE RISK; REVIEW; SYSTEMATIC REVIEW; URINARY TRACT INFECTION; VESICOURETERAL REFLUX;

EID: 33746102542     PISSN: 18712592     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eeus.2006.05.005     Document Type: Review

References (91)

1. Garin E.H., Campos A., and Homsy Y. Primary vesicoureteral reflux: review of current concepts. Pediatr Nephrol 12 (1998) 249-256
2. Jacobson S.H., Hansson S., and Jakobsson B. Vesico-ureteric reflux: occurrence and long-term risks. Acta Paediatr Scand Suppl 431 (1999) 22-30
3. Bailey R. Vesicoureteric reflux in healthy infants and children. In: Hodson J., and Kincaid-Smith P. (Eds). Reflux nephropathy (1997), Masson Publishing, New York 56-61
4. Sillén U. Vesicoureteral reflux in infants. Pediatr Nephrol 13 (1999) 355-361
5. Mackie G.G., Awang H., and Stephens F.D. The ureteric orifice: The embryologic key to radiologic status of duplex kidneys. J Pediatr Surg 10 (1975) 473-481
6. Avni E.F., and Schulman C.C. The origin of vesico-ureteral reflux in male newborns: further evidence in favor of a transient fetal urethral obstruction. Br J Urol 78 (1996) 454-459
7. Koff S.A. Relationship between dysfunctional voiding and reflux. J Urol 148 (1992) 1703-1705
8. Burger R.H., and Smith C. Hereditary and familial vesicoureteral reflux. J Urol 106 (1971) 845-851
9. Noe H.N., Wyatt R.J., Peeden J.N., and Rivas M.L. The transmission of vesicoureteric reflux from parent to child. J Urol 148 (1992) 1869-1871
10. Feather S.A., Malcolm S., Woolf A.S., Wright V., Blaydon D., Reid C.J.D., et al. Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1. Am J Hum Genet 66 (2000) 1420-1425
11. DeVargas A., Evans K., Ransley P., Rosenberg A.R., Rothwell D., Sherwood T., et al. A family study of vesicoureteric reflux. J Med Genet 15 (1978) 85-92
12. Hallowell J.G., and Greenfield S.P. Screening siblings for vesicoureteral reflux. J Urol 168 (2002) 2138-2141
13. Greenfield S.P. (Editorial comment) Screening siblings for vesicoureteral reflux. J Urol 168 (2002) 2141
14. International Reflux Study Committee. Medical versus surgical treatment of primary vesicoureteral reflux. Pediatrics 67 (1981) 392-400
15. Craig J.C., Irwig L.M., Christie J., Lam A., Onikul E., Knight J.F., et al. Variation in the diagnosis of vesicoureteric reflux using micturating cystourethrography. Pediatr Nephrol 11 (1997) 455-459
16. Ward V.L., Barnewolt C.E., Strauss K.G., Lebowitz R.L., Venkatakrishnan V., Stehr M., et al. Radiation exposure reduction during voiding cystourethrography in pediatric porcine model of vesicoureteral reflux. Radiology 238 (2006) 96-106
17. Dacher J.N. Diagnostic procedures excluding MRI, nuclear medicine, and video-urodynamics. In: Fotter R. (Ed). Pediatric uroradiology (2001), Springer, Berlin Heidelberg New York 1-14
18. Ismaili K., Avni F.E., and Hall M. Results of systematic voiding cystourethrography in infants with antenatally diagnosed renal pelvis dilation. J Pediatr 141 (2002) 21-24
19. Dacher J.N., Mandell J., and Lebowitz R.L. Urinary tract infection in neonates in spite of prenatal diagnosis of hydronephrosis. Pediatr Radiol 22 (1992) 401-405
20. Mandell G.A., Eggli D.F., Gilday D.L., Heyman S., Leonard J.C., Miller J.H., et al. Procedure guideline for radionuclide cystography in children. Society of Nuclear Medicine. J Nucl Med 38 (1997) 1650-1654
21. Piepsz A., and Ham H. Pediatric applications of renal nuclear medicine. Semin Nucl Med 36 (2006) 16-35
22. De Sadeleer C., De Boe V., Keuppens F., Desprechins B., Verboven M., and Piepsz A. How good is Tc-99m MAG3 indirect cystography?. Eur J Nucl Med 21 (1994) 223-227
23. Avni F.E., Hall M., Damry N., and Schurmans T. Vesicoureteric reflux. In: Fotter R. (Ed). Pediatric uroradiology (2001), Springer, Berlin Heidelberg New York 121-143
24. Blane C.E., DiPietro M.A., Zerin J.M., Sedman A.B., and Bloom D.A. Renal sonography is not a reliable screening examination for vesicoureteral reflux. J Urol 150 (1993) 752-755
25. Ismaili K., Hall M., Piepsz A., Wissing K.M., Collier F., Schulman C., et al. Primary vesicoureteral reflux detected among neonates with a history of fetal renal pelvis dilatation: A prospective clinical and imaging study. J Pediatr 148 (2006) 222-227
26. Avni E.F., Ayadi K., Rypens F., Hall M., and Schulman C.C. Can careful ultrasound examination of the urinary tract exclude vesicoureteric reflux in the neonate?. Br J Radiol 70 (1997) 977-982
27. Ismaili K., Hall M., Piepsz A., Alexander M., Schulman C., and Avni F.E. Insights into the pathogenesis and natural history of fetuses with renal pelvis dilatation. Eur Urol 48 (2005) 207-214
28. Toiviainen-Salo S., Garel L., Grignon A., Dubois J., Rypens F., Boisvert J., et al. Fetal hydronephrosis: is there hope for consensus?. Pediatr Radiol 34 (2004) 519-529
29. Petrikovsky B.M., Cuomo M.I., Schneider E.P., Wyse L.J., Cohen H.L., and Lesser M. Isolated fetal hydronephrosis: beware the effect of bladder filling. Prenat Diagn 15 (1995) 827-829
30. Newell S.J., Morgan M.E., McHugo J.M., White R.H., Taylor C.M., and Chapman S. Clinical significance of antenatal calyceal dilatation detected by ultrasound. Lancet 336 (1990) 372
31. Risdon R.A. The small scarred kidney in childhood. Pediatr Nephrol 7 (1993) 361-364
32. Robben S.G.F., Boesten M., Linmans J., Lequin M.H., and Nijman R.M. Significance of thickening of the wall of the renal collecting system in children: an ultrasound study. Pediatr Radiol 29 (1999) 736-740
33. Ismaili K., Avni F.E., Wissing K.M., and Hall M. Long-term clinical outcome of infants with mild and moderate fetal pyelectasis: validation of neonatal ultrasound as a screening tool to detect significant nephro-uropathies. J Pediatr 144 (2004) 759-765
34. Kenda R.B. Imaging techniques for the detection of vesicoureteric reflux: what and when?. Nephrol Dial Transplant 16 (2001) 4-7
35. Kenda R.B., Novljan G., Kenig A., Hojker S., and Fettich J.J. Echo-enhanced ultrasound voiding cystography in children: a new approach. Pediatr Nephrol 14 (2000) 297-300
36. Darge K., Duetting T., and Zieger B. Diagnosis of VUR with echo-enhanced voiding urosonography. Radiology 38 (1998) 405-409
37. Marra G., Barbieri G., Moioli C., Assael B.M., Grumieri G., and Caccamo M.L. Mild fetal hydronephrosis indicating vesicoureteric reflux. Arch Dis Child 70 (1994) F147-F150
38. Stocks A., Richards D., Frentzen B., and Richard G. Correlation of prenatal renal pelvic anteroposterior diameter with outcome in infancy. J Urol 155 (1996) 1050-1052
39. Jaswon M.S., Dibble L., Puri S., Davis J., Young J., Dave R., et al. Prospective study of outcome in antenatally diagnosed renal pelvis dilatation. Arch Dis Child 80 (1999) F135-F138
40. Acton C., Pahuja M., Opie G., and Woodward A. A 5-year audit of 778 neonatal renal scans (Part 1): perplexing pyelectasis and suggested protocol for investigation. Australas Radiol 47 (2003) 349-353
41. Moorthy I., Joshi N., Cook J.V., and Warren M. Antenatal hydronephrosis: negative predictive value of normal postnatal ultrasound, a 5-year study. Clin Radiol 58 (2003) 964-970
42. Yeung C.K., Godley M.L., Dhillon H.K., Gordon I., Duffy P.G., and Ransley P.G. The characteristics of primary vesico-ureteric reflux in male and female infants with prenatal hydronephrosis. Br J Urol 80 (1997) 319-327
43. Winberg J., Andersen H.J., Bergström T., Jacobsson B., Larson H., and Lincoln K. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand Suppl 252 (1974) 1-20
44. Woolf A.S., and Wilcox D.T. Understanding primary vesicoureteric reflux and associated nephropathies. Current Paediatr 14 (2004) 563-567
45. Smellie J.M. Do urinary tract infections really matter in children?. Proc Roy Soc Med 8 (1972) 65
46. Kunin C.M., Deutscher R., and Paquin A. Urinary tract infections in school children: An epidemiologic, clinical and laboratory study. Medicine 43 (1964) 91-130
47. Hansson S., and Jodal U. Urinary tract infection. In: Avner E.D., Harmon W.E., and Niaudet P. (Eds). Pediatric Nephrology. 5th edition (2004), Lippincot Williams and Wilkins, Philadelphia 1007-1025
48. Rushton H.G., Majd M., and Jantausch B. Renal scarring following reflux and nonreflux pyelonephritis: evaluation with 99m-technetium-dimercaptosuccinic acid scintigraphy. J Urol 147 (1992) 1327-1332
49. Jakobsson B., Berg U., and Svensson L. Renal scarring after acute pyelonephritis. Arch Dis Child 70 (1994) 111-115
50. Wullt B., Bergsten G., Fischer H., Godaly G., Karpman D., Leijonhufvud I., et al. The host response to urinary tract infection. Infect Dis Clin North Am 17 (2003) 279-301
51. Svanborg-Edén C., and Jodal U. Attachement of Escherichia Coli to urinary sediment cells from urinary tract infection-prone and healthy children. Infect Immun 26 (1979) 837-840
52. Dacher J.N., Hitzel A., Avni F.E., and Vera P. Imaging strategies in pediatric urinary tract infection. Eur Radiol 15 (2005) 1283-1288
53. Hoberman A., Charron M., and Hickey R.W. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 16 (2003) 195-202
54. Moorthy I., Easty A., McHugh K., Ridout D., Biassoni L., and Gordon I. The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection. Arch Dis Child 90 (2005) 733-736
55. Hansson S., Dhamey M., and Sigstrom O. DMSA scintigraphy instead of VCUG for infants with urinary tract infection. J Urol 172 (2004) 1071-1073
56. Homayoon K., Chen J.J., Cummings J.M., and Steinhardt G.F. Voiding dysfunction: outcome in infants with congenital vesicoureteral reflux. Urology 66 (2005) 1091-1094
57. Upadhyay J., Bolduc S., Bägli D.J., McLorie G.A., Khouri A.E., and Farhat W. Use of dysfunctional voiding symptom score to predict resolution of vesicoureteral reflux in children with voiding dysfunction. J Urol 169 (2003) 1842-1846
58. Snodgrass W. The impact of treated dysfunctional voiding on the nonsurgical management of vesicoureteral reflux. J Urol 160 (1998) 1823-1825
59. Koff S.A., Wagner T.T., and Jayanthi V.R. The relationship among dysfunctional elimination syndromes, primary vesicoureteral reflux and urinary tract infections in children. J Urol 160 (1998) 1019-1022
60. Herndon C.D.A., DeCambre M., and McKenna P.H. Changing concepts concerning the management of vesicoureteral reflux. J Urol 166 (2001) 1439-1443
61. North American Pediatric Renal Transplant Cooperative Study 2004 Annual Report.
62. Pistor K., Schärer K., Olbing H., and Tamminen-Möbius T. Children with chronic renal failure in the Federal Republic of Germany: Primary renal diseases, age and intervals from early renal failure to renal death. Clin Nephrol 23 (1985) 278-284
63. Ardissino G., Avolio L., Dacco V., Testa S., Marra G., Vigano S., et al. Long-term outcome of vesicoureteral reflux associated chronic renal failure in children. Data from the Italkid Project. J Urol 172 (2004) 305-310
64. Stock J.A., Wilson D., and Hanna M.K. Congenital reflux nephropathy and severe unilateral fetal reflux. J Urol 160 (1998) 1017-1018
65. Beetz R. May we go on with antibacterial prophylaxis for urinary tract infections?. Pediatr Nephrol 21 (2006) 5-13
66. Ismaili K., Avni F.E., Wissing K.M., Piepsz A., Aubert D., Cochat P., et al. Current management of infants with fetal renal pelvis dilatation: a survey by French-speaking pediatric nephrologists and urologists. Pediatr Nephrol 19 (2004) 966-971
67. Schwab Jr. C.W., Wu H.Y., Selman H., Smith G.H., Snyder III H.M., and Canning D.A. Spontaneous resolution of vesicoureteral reflux: a 15-year perspective. J Urol 168 (2002) 2594-2599
68. Smellie J.M., Grüneberg R.N., and Bantock H.M. Prophylactic co-trimoxazole and trimethoprim in the management of urinary tract infection in children. Pediatr Nephrol 2 (1988) 12-17
69. Greenfield S.P. Management of vesicoureteral reflux in children. Curr Urol Rep 2 (2001) 113-121
70. Williams G., Lee A., and Craig J.C. Antibiotics for prevention of urinary tract infection in children: a systematic review of randomized controlled trials. J Pediatr 138 (2001) 868-874
71. Garin E.H., Olavarria F., Garcia Nieto V., Valenciano B., Campos A., and Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: A multicenter, randomized, controlled study. Pediatrics 117 (2006) 626-632
72. Al-Sayyad A.J., Pike J.G., and Leonard M.P. Can prophylactic antibiotics safely be discontinued in children with vesicoureteral reflux?. J Urol 174 (2005) 1587-1589
73. Schoen E.J. Circumcision for preventing urinary tract infections in boys: North American view. Arch Dis Child 90 (2005) 772-773
74. Malone P.S. Circumcision for preventing urinary tract infections in boys: European view view. Arch Dis Child 90 (2005) 772-773
75. Wiswell T.E., and John K. Lattimer lecture. Prepuce presence portends prevalence of potentially perilous periurethral pathogens. J Urol 148 (1992) 739-742
76. American Academy of Pediatrics. Circumcision policy statement. Pediatrics 103 (1999) 686-693
77. Canadian Paediatric Society. Neonatal circumcision revisited. Fetus and newborn Committee, Canadian Paediatric Society. CMAJ 15 (1996) 769-780
78. Singh-Grewal D., Macdessi J., and Craig J. Circumcision for the prevention of urinary tract infection in boys: a systematic review of randomized trials and observational studies. Arch Dis Child 90 (2005) 853-858
79. Rushton H.G. Vesicoureteral reflux and scarring. In: Avner E.D., Harmon W.E., and Niaudet P. (Eds). Pediatric Nephrology. 5th edition (2004), Lippincot Williams and Wilkins, Philadelphia 1027-1048
80. Heidenreich A., Özgur E., Becker T., and Haupt G. Surgical management of vesicoureteral reflux in pediatric patients. World J Urol 22 (2004) 96-106
81. The Birmingham reflux study group. Prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children: five years observation. Br Med J 295 (1987) 237-241
82. Olbing H., Claesson I., Ebel K.D., Sappanen U., Smellie J.M., Tamminen-Mobius T., et al. Renal scars and parenchymal thinning in children with vesicoureteral reflux: a 5-year report of the International Reflux Study in Children (European branch). J Urol 148 (1992) 1653-1656
83. Weiss R., Duckett J., and Spitzer A. Results of randomized clinical trial of medical vs. surgical management of infants and children with grades III and IV primary vesicoureteral reflux (United States). J Urol 148 (1992) 1667-1673
84. Nijman R.J.M. Vesicoureteric reflux: to operate or not?. Lancet 357 (2001) 1309-1310
85. Mor Y., Leibovitch I., and Fridmans A. Late post-reimplantation ureteral obstruction during pregnancy: a transient phenomenon?. J Urol 170 (2003) 845-848
86. Bukowski T.P., Betrus G.G., Aquilina J.W., and Perlmutter A.D. Urinary tract infections and pregnancy in women who underwent antireflux surgery in childhood. J Urol 159 (1998) 1286-1289
87. Van Gool J.D., Hjalmas K., Tamminen-Mobius T., and Olbing H. Historical clues to the complex of dysfunctional voiding urinary tract infection and vesicoureteral reflux. The International Reflux Study in Children. J Urol 148 (1992) 1699-1702
88. Schulman C., Simon J., Pamart D., and Avni F.E. Endoscopic treatment of vesicoureteral reflux in children. J Urol 138 (1987) 950-952
89. Chertin B., Colhoun E., Velayudham M., and Puri P. Endoscopic treatment of vesicoureteral reflux: 11 to 17 years of followup. J Urol 167 (2002) 1443-1445
90. O'Donnell B., and Puri P. Treatment of vesicoureteric reflux by endoscopic injection of Teflon. Br Med J 289 (1984) 7-9
91. Elder J.S., Diaz M., Caldamone A.A., Cendron M., Greenfield S., Hurwitz R., et al. Endoscopic therapy for vesicoureteral reflux: A meta-analysis. I. Reflux resolution and urinary tract infection. J Urol 175 (2006) 716-722