Photochemical route to the synthesis of thiolane 1-oxides

Journal of the American Chemical Society

Volumn 128, Issue 28, 2006, Pages 9040-9041

  Winkler, Jeffrey D ^a   Lee, Esther C Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXIDE; THIOL DERIVATIVE; THIOLANE 1 OXIDE; UNCLASSIFIED DRUG;

ARTICLE; CYCLOADDITION; IRRADIATION; OXIDATION; PHOTOCHEMISTRY; REACTION ANALYSIS; SYNTHESIS;

MOLECULAR STRUCTURE; PHOTOCHEMISTRY; SULFHYDRYL COMPOUNDS;

EID: 33746089542     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja060962r     Document Type: Article

References (15)

1. Recipient of the Novartis Graduate Fellowship in Organic Chemistry. 2004-2005.
2. For the first synthesis of ingenol, see: Winkler, J. D.; Rouse, M. B.; Greaney, M. F.; Harrison, S. J.; Jeon, Y. T. J. Am. Chem. Soc. 2002, 124, 9726-9728.
3. For more recent total syntheses of ingenol, see: (a) Tanino, K.; Onuki, K.; Miyashita, M.; Nakamura, T.; Takahashi, Y.; Kuwajima, I. J. Am. Chem. Soc. 2003, 125, 1498-1500.
4. (b) Nickel, A.; Maruyama, T.; Tang, H.; Murphy, P.; Greene, B.; Yusuff, N.; Wood, J. L. J. Am. Chem. Soc. 2004, 126, 16300-16301.
5. A preliminary report on our second-generation approach to the synthesis of ingenol has appeared: Winkler, J. D.; Lee, E. C. Y.; Nevels, L. I. Org. Lett. 2005, 7, 1489-1491.
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