Cyclodextrin-containing poly(ethyleneoxide) tablets for the delivery of poorly soluble drugs: Potential as buccal delivery system

International Journal of Pharmaceutics

Volumn 319, Issue 1-2, 2006, Pages 63-70

  Cappello, Brunella ^a   De Rosa, Giuseppe ^a   Giannini, Lucia ^a   La Rotonda, Maria Immacolata ^a   Mensitieri, Giuseppe ^a   Miro, Agnese ^a   Quaglia, Fabiana ^a   Russo, Roberto ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

Author keywords

Buccal delivery; Carvedilol; Hydroxypropyl cyclodextrin; Mucoadhesion

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CARVEDILOL; MACROGOL;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; MOUTH MUCOSA; NONHUMAN; PHYSICAL PHENOMENA; PRIORITY JOURNAL; TABLET COMPRESSION;

ADMINISTRATION, BUCCAL; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BETA-CYCLODEXTRINS; CARBAZOLES; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DRUG DELIVERY SYSTEMS; EXCIPIENTS; MODELS, CHEMICAL; MOUTH MUCOSA; PERMEABILITY; POLYETHYLENE GLYCOLS; PROPANOLAMINES; SOLUBILITY; SWINE; TABLETS; TIME FACTORS;

EID: 33746047742     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.03.031     Document Type: Article

References (24)

1. Apicella A., Cappello B., Del Nobile M.A., La Rotonda M.I., Mensitieri G., and Nicolais L. Poly(ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release. Biomaterials 14 (1993) 83-90
2. Bibby D.C., Davies N.M., and Tucker I.G. Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems. Int. J. Pharm. 197 (2000) 1-11
3. Bottenberg P., Cleymaet R., de Muynck C., Remon J.P., Coomans D., Michotte Y., and Slop D. Development and testing of bioadhesive, fluoride-containing slow-release tablets for oral use. J. Pharm. Pharmacol. 43 (1991) 457-464
4. Cappello B., Del Nobile M.A., La Rotonda M.I., Mensitieri G., Miro A., and Nicolais L. Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system. Farmaco 49 (1994) 809-818
5. Chowdary K.P., and Kamalakara R.G. Controlled release of nifedipine from mucoadhesive tablets of its inclusion complexes with beta-cyclodextrin. Pharmazie 58 (2003) 721-724
6. Di Colo G., Burgalassi S., Chetoni P., Fiaschi M.P., Zambito Y., and Saettone M.F. Relevance of polymer molecular weight to the in vitro/in vivo performances of ocular inserts based on poly(ethylene oxide). Int. J. Pharm. 220 (2001) 169-177
7. Giunchedi P., Maggi L., La Manna A., and Conte U. Modification of the dissolution behaviour of a water-insoluble drug, naftazone, for zero-order release matrix preparation. J. Pharm. Pharmacol. 46 (1994) 476-480
8. Jain A.C., Aungst B.J., and Adeyeye M.C. Development and in vivo evaluation of buccal tablets prepared using danazol-sulfobutylether 7 beta-cyclodextrin (SBE 7) complexes. J. Pharm. Sci. 91 (2002) 1659-1668
9. Kim C.J. Drug release from compressed hydrophilic POLYOX-WSR tablets. J. Pharm. Sci. 84 (1995) 303-306
10. Kim C.J. Effects of drug solubility, drug loading, and polymer molecular weight on drug release from Polyox tablets. Drug Dev. Ind. Pharm. 24 (1998) 645-651
11. Koester L.S., Xavier C.R., Mayorga P., and Bassani V.L. Influence of beta-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets. Eur. J. Pharm. Biopharm. 55 (2003) 85-91
12. Narasimhan B. Mathematical models describing polymer dissolution: consequences for drug delivery. Adv. Drug Deliv. Rev. 48 (2001) 195-210
13. Narasimhan B., and Peppas N.A. In: Park K. (Ed). The Role of Modeling in the Development of Future Controlled Release Devices (1997), American Chemical Society, Washington, DC 529-557
14. Okimoto K., Rajewski R.A., and Stella V.J. Release of testosterone from an osmotic pump tablet utilizing (SBE)7m-beta-cyclodextrin as both a solubilizing and an osmotic pump agent. J. Control Release 58 (1999) 29-38
15. Peppas N.A., Wu J.C., and von Meerwall E.D. Mathematical modeling and experimental characterization of polymer dissolution. Macromolecules 27 (1994) 5626-5638
16. Pose-Vilarnovo B., Rodriguez-Tenreiro C., Rosa dos Santos J.F., Vazquez-Doval J., Concheiro A., Alvarez-Lorenzo C., and Torres-Labandeira J.J. Modulating drug release with cyclodextrins in hydroxypropyl methylcellulose gels and tablets. J. Control Release 94 (2004) 351-363
17. Quaglia F., Varricchio G., Miro A., La Rotonda M.I., Larobina D., and Mensitieri G. Modulation of drug release from hydrogels by using cyclodextrins: the case of nicardipine/beta-cyclodextrin system in crosslinked polyethylenglycol. J. Control Release 71 (2001) 329-337
18. Rao V.M., Haslam J.L., and Stella V.J. Controlled and complete release of a model poorly water-soluble drug, prednisolone, from hydroxypropyl methylcellulose matrix tablets using (SBE)(7m)-beta-cyclodextrin as a solubilizing agent. J. Pharm. Sci. 90 (2001) 807-816
19. Rathbone M.J., Ponchel G., and Chazali F.A. In: Rathbone M.J. (Ed). Systemic Oral Mucosal Drug Delivery and Delivery Systems (1996), Marcel Dekker, New York
20. Sangalli M.E., Zema L., Maroni A., Foppoli A., Giordano F., and Gazzaniga A. Influence of betacyclodextrin on the release of poorly soluble drugs from inert and hydrophilic heterogeneous polymeric matrices. Biomaterials 22 (2001) 2647-2651
21. Tiwari D., Goldman D., Sause R., and Madan P.L. Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations. AAPS Pharm. Sci. 1 (1999) E13
22. Veuillez F., Rieg F.F., Guy R.H., Deshusses J., and Buri P. Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. Int. J. Pharm. 231 (2002) 1-9
23. Villar-Lopez M.E., Nieto-Reyes L., Anguiano-Igea S., Otero-Espinar F.J., and Blanco-Mendez J. Formulation of triamcinolone acetonide pellets suitable for coating and colon targeting. Int. J. Pharm. 179 (1999) 229-235
24. Zarzycki P.K., and Lamparczyk H. The equilibrium constant of beta-cyclodextrin-phenolphtalein complex; influence of temperature and tetrahydrofuran addition. J. Pharm. Biomed. Anal. 18 (1998) 165-170