Propylthiouracil-induced hypersensitivity syndrome

Turkish Journal of Pediatrics

Volumn 48, Issue 2, 2006, Pages 162-165

  Aycan, Zehra ^a   Arhan, Ebru ^a   Çetinkaya, Ergun ^a   Vidinlisan, Sadi ^a   Menekşe, Nurcan ^a   Yücel, Hüsniye ^a   Çakar, Nilgün ^a  

^a Social Security Hospital   (Turkey)

Author keywords

Hypersensitivity; Propylthiouracil; Vasculitis

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN; LEVOTHYROXINE; LIOTHYRONINE; METHYLPREDNISOLONE; MICROSOME ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROPRANOLOL; PROPYLTHIOURACIL; THIAMAZOLE; THYROGLOBULIN ANTIBODY; THYROTROPIN; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE;

ABNORMAL RESPIRATORY SOUND; ADOLESCENT; ANCA ASSOCIATED VASCULITIS; ARTHRITIS; ARTHROPATHY; ARTICLE; ASPIRATION BIOPSY; BLOOD PRESSURE; BODY HEIGHT; BODY TEMPERATURE; BODY WEIGHT; BREATHING; CARDIOMEGALY; CASE REPORT; COUGHING; DRUG DOSE REGIMEN; DRUG ERUPTION; DRUG FEVER; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; DYSPNEA; ECCHYMOSIS; ECHOCARDIOGRAPHY; ERYTHROCYTE SEDIMENTATION RATE; ERYTHROCYTE VOLUME; EUTHYROIDISM; EXOPHTHALMOS; FAMILY HISTORY; FEMALE; FOLLOW UP; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HASHIMOTO DISEASE; HEART BEAT; HEART PALPITATION; HEART VENTRICLE HYPERTROPHY; HEMATOCRIT; HUMAN; HUMAN TISSUE; HYPERTHYROIDISM; LEUKOCYTE; LEUKOCYTOCLASTIC VASCULITIS; MALAISE; MITRAL VALVE REGURGITATION; PATIENT REFERRAL; PERICARDIAL DISEASE; PERICARDIAL EFFUSION; PLEURA FLUID; POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN DISEASE; SORE THROAT; TELECARDIOLOGY; THORACOCENTESIS; THORAX PAIN; THYROID FUNCTION TEST;

ADOLESCENT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTITHYROID AGENTS; COUGH; DYSPNEA; FEMALE; FEVER; HUMANS; PROPYLTHIOURACIL; VASCULITIS, ALLERGIC CUTANEOUS;

EID: 33746041846     PISSN: 00414301     EISSN: 00414301     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Cooper DS. Antithyroid drugs. N Engl J Med 1984; 311: 1353-1362.
2. Stankus SJ, Johnson NT. Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure. Chest 1992; 102: 1595-1596.
3. Sato H, Hattori M, Fujieda M, et al. High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset Graves' disease treated with propylthiouracil. J Clin Endocrinol Metab 2000; 85 (11): 4270-4273.
4. Dolman KM, Gans R, Vervaat TJ, et al. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 1993; 342: 651-652.
5. Vasily DB, Tyler WB. Propylthiouracil-induced cutaneous vasculitis. JAMA 1980; 243: 458-461.
6. Fisher DA. Thyroid disorders in childhood and adolescence. In: Sperling MA (ed). Pediatric Endocrinology, 2nd ed. New York: Elsevier Science; 2002.
7. Harper L, Cockwell P, Savage CO. Case of proyplthiouracil-induced ANCA associated small vessel vasculitis. Nephrol Dial Transplant 1998; 13: 455-458.
8. Griswold WR, Mendosa SA, Johnson W, Nichols S. Vasculitis associated with propylthiouracil: evidence for immune complex pathogenesis and response to therapy. West J Med 1978; 128: 543-546.
9. Kitahara T, Hiromura K, Maezawa A, et al. Case of propylthiouracil induced vasculitis associated with anti-neutrocytoplasmic antibody (ANCA): review of literature. Clin Nephrol 1997; 47: 336-340.
10. Wing SS, Fantus IG. Adverse immunologic effects of antithyroid drugs. Can Med Assoc J 1987; 136: 121-126.
11. Wolf D, Ben-Yehuda A, Okon E, Naparstek Y. Nodular vasculitis associated with propylthiouracil therapy. Cutis 1992; 49: 253-255.
12. Miller RM, Savige J, Nassis L, Cominos BI. Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leucocytoclastic vasculitis associated with antithyroid therapy in Graves disease. Australas J Dermatol 1998; 39: 96-99.
13. Oh BK, von Overveld GP, Macfarlane JD. Polyarthritis induced by propylthiouracil. Br J Rheumatol 1983; 22: 106-108.
14. Ohtsuka M, Yamashita Y, Doi M, Hasewaga S. Propylthiouracil induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody. Eur Respir J 1997; 10: 1405-1407.
15. Yuasa S, Hashimoto M, Yura T, et al. Antineutrophil cytoplasmic antibodies (ANCA)- associated crescentic glornerulonephritis and propylthiouracil therapy. Nephron 1996; 73: 701-703.
16. Yarman S, Sandalci O, Tanakol R, Azizerli H, Oǧuz H, Alagol F. Propylthiouracil-induced cutaneous vasculitis. Int J Clin Pharmacol Ther 1997; 35: 282-286.
17. Carrasco MD, Riera C, Clotet S, Grifol M, Foz M. Cutaneous vasculitis associated with propylthiouracil therapy. Arch Intern Med 1987; 147: 1677.
18. Alfetra A, Paggi A, De Rosa FG, Manfredini P, Addessi MA, Amorosso A. Antineutrophil cytoplasmic antibodies in autoimmune thyroid disorders. Endocr Res 1998; 24: 185-194.
19. Sera N, Ashiwaza K, Ando T, et al. Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves disease. Thyroid 2000; 10: 595-599.
20. Chastain MA, Russo GG, Boh EE, Chastain JB, Falabella A, Millikan LE. Propylthiouracil hypersensitivity: report of two patients with vasculitis and review of the literature. J Am Acad Dermatol 1999; 41: 757-764.
21. Vogt BA, Kim Y, Jennette C, Falk RJ, Burke BA, Sinaiko A. Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of treatment in children. J Pediatr 1994; 124: 986-988.
22. Kudoh Y, Kuroda S, Shimamoto K, Limura O. Propylthiouracil induced rapidly progressive glomerulonephritis and propylthiouracil therapy. Nephron 1996; 73: 701-703.