Novel synthesis of 4-fluoropyridines based on 2-fluoroallylic alcohols by succeeding Ireland-Claisen and aza-Cope rearrangements as key steps

Synthesis

Volumn , Issue 13, 2006, Pages 2085-2096

  Wittmann, Ulrich ^a   Tranel, Frank ^a   Fröhlich, Roland ^a   Haufe, Günter ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

2 fluoroallylic alcohols; 4 fluoropyridines; 3.3 sigmatropic rearrangements; Cascade reaction; Fluorinated amino acids; Heterocycles

Indexed keywords

ALCOHOLS; AMINO ACIDS; AROMATIZATION; CARBON DIOXIDE; REACTION KINETICS; SYNTHESIS (CHEMICAL);

2-FLUOROALLYLIC ALCOHOLS; 4-FLUOROPYRIDINES; [3.3]-SIGMATROPIC REARRANGEMENTS; CASCADE REACTION; FLUORINATED Α-AMINO ACIDS; HETEROCYCLES;

NITROGEN COMPOUNDS;

2 (2 FLUOROALLYL)OXAZOL 5(2H) ONE; 2 (4 CHLOROPHENYL) 4 FLUORO 3 HEPTYL 6 PHENYLPYRIDINE; 2 AMINO 4 FLUORO 2 PHENYLALKYL 4 ENOIC ACID; 2 ARYL 4 FLUORO 6 PHENYLPYRINE DERIVATIVE; 2 FLUOROALLYLIC ALCOHOL; 4 (2 FLUOROALLYL)OXAZOL 5(4H) ONE; 4 FLUORO 2,6 DIPHENYL 3 PROPYLPYRIDINE; 4 FLUORO 2,6 DIPHENYL 3 TRIDECYLPYRIDINE; 4 FLUORO 2,6 DIPHENYLPYRIDINE; 4 FLUORO 3 HEPTYL 2 (4 METHOXYPHENYL) 6 PHENYLPYRIDINE; 4 FLUORO 3 HEPTYL 2 (4 NITROPHENYL) 6 PHENYLPYRIDINE; 4 FLUORO 3 HEPTYL 2,6 DIPHENYLPYRIDINE; 4 FLUORO 3 HEPTYL 6 PHENYL 2 [4 (TRIFLUOROMETHYL)PHENYL]PYRIDINE; 4 FLUOROPYRIDINE DERIVATIVE; ALCOHOL; ALKYL GROUP; AMINO ACID; N AROYL SUBSTITUTED 2 AMINO 4 FLUORO 2 METHYL; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; BIOLOGICAL ACTIVITY; CYCLOPROPANATION; DECARBOXYLATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; FLUORINATION; HYDROLYSIS; REACTOR CASCADE; RING OPENING; ROOM TEMPERATURE; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

EID: 33746039262     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-942411     Document Type: Article

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