Telomere Protection: An Act of God

Current Biology

Volumn 16, Issue 14, 2006, Pages

  Szilard, Rachel K ^a   Durocher, Daniel ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EXODEOXYRIBONUCLEASE; NUCLEAR PROTEIN; PROTEIN SUBUNIT; SHELTERIN, HUMAN; SNM1B PROTEIN, HUMAN; TATA BINDING PROTEIN RELATED FACTOR; TELOMERE BINDING PROTEIN; TRF2 PROTEIN, HUMAN;

CELL CYCLE S PHASE; DNA REPAIR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; SHORT SURVEY; TELOMERE;

DNA REPAIR; EXODEOXYRIBONUCLEASES; GENE EXPRESSION REGULATION; HUMANS; NUCLEAR PROTEINS; PROTEIN SUBUNITS; S PHASE; TATA BOX BINDING PROTEIN-LIKE PROTEINS; TELOMERE; TELOMERE-BINDING PROTEINS;

EID: 33746023983     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.06.037     Document Type: Short Survey

References (18)

1. Cervantes R.B., and Lundblad V. Mechanisms of chromosome-end protection. Curr. Opin. Cell Biol. 14 (2002) 351-356
2. d'Adda di Fagagna F., Teo S.H., and Jackson S.P. Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 18 (2004) 1781-1799
3. Lydall D. Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways. J. Cell Sci. 116 (2003) 4057-4065
4. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
5. Liu D., O'Connor M.S., Qin J., and Songyang Z. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279 (2004) 51338-51342
6. Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., and de Lange T. Mammalian telomeres end in a large duplex loop. Cell 97 (1999) 503-514
7. Verdun R.E., Crabbe L., Haggblom C., and Karlseder J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell 20 (2005) 551-561
8. van Overbeek M., and de Lange T. Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phases. Curr. Biol. 16 (2006) 1295-1302
9. Freibaum B.D., and Counter C.M. hSnm1B is a novel telomere-associated protein. J. Biol. Chem. (2006) in press
10. Lenain C., Bauwens S., Amiard S., Brunori M., Giraud-Panis M.J., and Gilson E. The Apollo 5′-exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr. Biol. 16 (2006) 1303-1310
11. Bonatto D., Brendel M., and Henriques J.A. The eukaryotic Pso2p/Snm1p family revisited: in silico analyses of Pso2p A, B and Plasmodium groups. Comput. Biol. Chem. 29 (2005) 420-433
12. Demuth I., Digweed M., and Concannon P. Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation. Oncogene 23 (2004) 8611-8618
13. Moshous D., Callebaut I., de Chasseval R., Corneo B., Cavazzana-Calvo M., Le Deist F., Tezcan I., Sanal O., Bertrand Y., Philippe N., et al. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105 (2001) 177-186
14. Brandt V.L., and Roth D.B. Artemis: guarding small children and, now, the genome. J. Clin. Invest. 111 (2003) 315-316
15. van Steensel B., Smogorzewska A., and de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 (1998) 401-413
16. Wellinger R.J., Wolf A.J., and Zakian V.A. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72 (1993) 51-60
17. Sfeir A.J., Shay J.W., and Wright W.E. Fine-tuning the chromosome ends: the last base of human telomeres. Cell Cycle 4 (2005) 1467-1470
18. Sfeir A.J., Chai W., Shay J.W., and Wright W.E. Telomere-end processing the terminal nucleotides of human chromosomes. Mol. Cell 18 (2005) 131-138