The Novel Formulation Design of Self-emulsifying Drug Delivery Systems (SEDDS) Type O/W Microemulsion I: Enhancing Effects on Oral Bioavailability of Poorly Water Soluble Compounds in Rats and Beagle Dogs

Drug Metabolism And Pharmacokinetics

Volumn 20, Issue 4, 2005, Pages 244-256

  Araya, Hiroshi ^a   Nagao, Shunsuke ^a   Tomita, Mikio ^b   Hayashi, Masahiro ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

beagle dog; enhancing effect; gastrointestinal absorption; poorly water soluble compunds; rat; SEEDS type O W microemulsion

Indexed keywords

2,3-DIHYDRO-5-HYDROXY-2,2-DIPENTYL-4,6-DI-TERT-BUTYLBENZOFURAN; 4,6 DI TERT BUTYL 2,3 DIHYDRO 5 HYDROXY 2,2 DIPENTYLBENZOFURAN; AG 041R; AG-041R; BENZOFURAN DERIVATIVE; IBUPROFEN; INDOLE DERIVATIVE; KETOPROFEN; LIPID; SURFACTANT;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DOG; DRUG DELIVERY SYSTEM; DRUG DESIGN; EMULSION; MALE; METABOLISM; PARTICLE SIZE; RAT; SOLUBILITY; SPRAGUE DAWLEY RAT; STOMACH MUCOSA;

ANIMALS; AREA UNDER CURVE; BENZOFURANS; BIOLOGICAL AVAILABILITY; DOGS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; EMULSIONS; GASTRIC MUCOSA; IBUPROFEN; INDOLES; KETOPROFEN; LIPIDS; MALE; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 33745976753     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.20.244     Document Type: Article

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