Mechanism of central nervous system toxicity by irinotecan

Medical Hypotheses

Volumn 67, Issue 4, 2006, Pages 997-

  Kovacic, Peter ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; IRINOTECAN; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; CENTRAL NERVOUS SYSTEM DISEASE; COLORECTAL CANCER; CONJUGATION; DRUG INDICATION; DRUG INDUCED DISEASE; DRUG MECHANISM; ELECTRON TRANSPORT; HUMAN; LETTER; NEUROTOXICITY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON TRANSPORT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CENTRAL NERVOUS SYSTEM; COLORECTAL NEOPLASMS; ELECTROCHEMISTRY; HUMANS; MODELS, BIOLOGICAL;

EID: 33745968761     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.04.036     Document Type: Letter

References (5)

1. Hamberg P., Donders R.C.J.M., and ten Bokkel Huinink D. Central nervous system toxicity induced by irinotecan. J Natl Cancer Inst 98 (2006) 219 [and references therein]
2. Kovacic P., and Somanathan R. Neurotoxicity: the broad framework of electron transfer, oxidative stress and protection by antioxidants. Curr Med Chem - CNS Agents 5 (2005) 249-258
3. Kovacic P., Ames J.R., Grogan J.V., Bazra B., and Ryan M.D. Anticancer quinones and quinolines: mode of action via electron transfer and oxidative stress. In: Dryhurst G., and Niki K. (Eds). Redox chemistry and interfacial behavior of biological molecules (1988), Plenum Press, New York 295-307 [and references therein]
4. Kovacic P., and Osuna J.A. Mechanisms of anti-cancer agents: emphasis on oxidative stress and electron transfer. Curr Pharmaceut Des 6 (2000) 277-309
5. Poot M., and Pierce R.H. Detection of changes in mitochondrial function during apoptosis by simultaneous staining with multiple fluorescent dyes and correlated multiparameter flow cytometry. Cytometry 35 (1999) 311-317