Cerebral vasodilatation to exogenous NO is a measure of fitness for life at altitude

Stroke

Volumn 37, Issue 7, 2006, Pages 1754-1758

  Appenzeller, Otto ^a,h   Claydon, Victoria E ^b   Gulli, Giosué ^c   Qualls, Clifford ^d   Slessarev, Marat ^e   Zenebe, Guta ^f   Gebremedhin, Amha ^g   Hainsworth, Roger ^c  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF NEW MEXICO   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f Department of Neurology   (Ethiopia)

^g ADDIS ABABA UNIVERSITY   (Ethiopia)

^h NMHEMC Research Foundation   (United States)

Author keywords

Altitude; Cerebral hypoxia; Cerebrovascular circulation; Evolution; Nitric oxide

Indexed keywords

NITRIC OXIDE; CARBON DIOXIDE; DIAGNOSTIC AGENT; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; NITRIC OXIDE DONOR; OXYGEN;

ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; END TIDAL CARBON DIOXIDE TENSION; ETHIOPIA; FITNESS; HEMATOCRIT; HUMAN; HYPOXIA; MALADJUSTMENT; MALE; OXYGEN SATURATION; PERU; PRIORITY JOURNAL; VASODILATATION; ACCLIMATIZATION; AMERICAN INDIAN; BLOOD; BRAIN CIRCULATION; BRAIN HYPOXIA; BREATH ANALYSIS; COMPARATIVE STUDY; DRUG EFFECT; ETHNOLOGY; GENETIC SELECTION; GENETICS; NEGRO; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACCLIMATIZATION; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALTITUDE SICKNESS; BLOOD FLOW VELOCITY; BREATH TESTS; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; ETHIOPIA; HEMATOCRIT; HUMANS; HYPOXIA, BRAIN; INDIANS, SOUTH AMERICAN; ISOSORBIDE DINITRATE; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGLYCERIN; OXYGEN; PERU; PHYSICAL FITNESS; SELECTION (GENETICS);

EID: 33745964243     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000226973.97858.0b     Document Type: Article

References (26)

1. West JB. Highest permanent human habitation. High Alt Med Biol. 2002;3:401-407.
2. Beall CM, Decker MJ, Brittenham GM, Kushner I, Gebremedhin A, Strohl KP. An Ethiopian pattern of human adaptation to high-altitude hypoxia. Proc Natl Acad Sci. 2002;99:17215-17218.
3. Monge CC, León-Velarde F. El Reto Fisiológico de Vivir en Los Andes. Lima, Peru: IFEA, Instituto Francés de Estudios Andinos, tomo 177 "Travaux de l'Institut Français d'Études Andines; 2003:435.
4. Appenzeller O, Thomas PK, Ponsford S, Gamboa JL, Cáceda R, Milner P. Acral paresthesias in the Andes and neurology at sea level. Neurology. 2002;59:1532-1535.
5. Busch T, Bartsch P, Pappert D, Grunig E, Hildebrandt W, Elser H, Falke KJ, Swenson ER. Hypoxia decreases exhaled nitric oxide in mountaineers susceptible to high-altitude pulmonary edema. Am J Respir Crit Care Med. 2001;163:368-373.
6. Thomas PK, King RH, Feng SF, Muddle JR, Workman JM, Gamboa J, Tapia R, Vargas M, Appenzeller O. Neurological manifestations in chronic mountain sickness: the burning feet-burning hands syndrome. J Neurol Neurosurg Psychiatry. 2000;69:447-452.
7. Appenzeller O, Passino C, Roach R, Gamboa J, Gamboa A, Bernardi L, Bonfichi M, Malcovati L. Cerebral vasoreactivity in Andeans and headache at sea level. J Neurol Sci. 2004;219:101-106.
8. León-Velarde F, McCullough RG, McCullough RE, Reeves JT. Proposal for scoring severity in chronic mountain sickness (CMS). In: Hypoxia: Through the Lifecycle. Roach RC, Wagner PD, Hackett PH, eds. New York, NY: Kluwer Academic/Plenum Publishers; 2003:339-354.
9. Markwalder TM, Grolimund P, Seiler RW, Roth F, Asalid R. Dependency of blood flow velocity in the middle cerebral artery on end-tidal carbon dioxide partial pressure-a transcranial Doppler study. J Cereb Blood Flow Metab. 1984;4:368-372.
10. Castellano AE, Micieli G, Bellantonio P, Buzzi MG, Marcheselli S, Pompeo F, Rossi F, Nappi G. Indomethacin increases the effect of isosorbide dinitrate on cerebral hemodynamic in migraine patients: pathogenesis and therapeutic implications. Cephalalgia. 1998;18:591-592.
11. Jansen GFA, Krins A, Basnyat B, Bosch A, Odoom JA. Cerebral autoregulation in subjects adapted and not adapted to high altitude. Stroke. 2000;31:2314-2318.
12. Norcliffe LJ, Rivera-Ch M, Claydon VE, Moore JP, Leon-Velarde F, Appenzeller O, Hainsworth R. Cerebrovascular responses to hypoxia and hypocapnia in high altitude dwellers. J Physiol. 2005;566:287-294.
13. Singel DJ, Stamler JS. Blood traffic control. Nature. 2004;430:297.
14. Hobson JA. Sleep is of the brain, by the brain and for the brain. Nature. 2005;437:1254-1256.
15. Nee S, Colegrave N, West SA, Grafen A. The illusion of invariant quantities in life histories. Science. 2005;309:1236-1239.
16. Monge CC, Whittembury J. Chronic mountain sickness. Johns Hopkins Med J. 1976;139:87-89.
17. Hurtado A. Chronic mountain sickness. J Am Med Assoc. 1942;120:1278-1282.
18. Leon-Velarde F, Gamboa A, Chuquiza JA, Esteba WA, Rivera-Chira M, Monge CC. Hematological parameters in high altitude resident living at 4355, 4660, and 5500 meters above sea level. High Alt Med Biol. 2000;1:97-104.
19. Leon-Velarde F, Arregui A. Desadaptacion a la Vida en las Grandes Alturas. Vol 85. Lima, Peru: IFEA, Instituto Frances de Estudios Andinos; 1994:69.
20. Darwin C. On the Origin of Species. London, UK: John Murray; 1859.
21. Kettlewell HBD. The Evolution of Mechanism: The Study of Recurring Necessity. Oxford, UK: Oxford University Press; 1973.
22. Pennisi E. Louse DNA suggests close contact between early humans. Science. 2003;306:210-214.
23. Hammock EAD, Young LJ. Microsatellite instability generates diversity in brain and social behavior. Science. 2005;308:1630-1634.
24. Wanby P, Teerlink T, Brudin L, Brattstrom L, Nilsson I, Palmqvist P, Carlsson M. Asymetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population. Atherosclerosis. 2006;185:271-277.
25. Howard TD, Giles WH, Xu J, Wozniak MA, Malarcher AM, Lange LA, Macko RF, Basehore MJ, Meyers DA, Cole JW, Kittner SJ. Promoter Polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women. Stroke. 2005;36:1848-1851.
26. Paz Y, Frolkis I, Kramer A, Pevni D, Shapira I, Lev-Ran O, Mohr R. Comparison of vasoactive responses of left and right internal thoracic arteries to isosorbide-dinitrate and nitroglycerin: an in vitro study. J Card Surg. 2003;18:279-285.