Site-specific delivery of dexamethasone from biodegradable implants reduces formation of pericardial adhesions in rabbits

Journal of Biomedical Materials Research - Part A

Volumn 78, Issue 2, 2006, Pages 276-282

  Chorny, Michael ^a,c   Mishaly, David ^b   Leibowitz, Avshalom ^b   Domb, Abraham J ^a   Golomb, Gershon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Biodegradable implant; Controlled drug release; Dexamethasone; Local delivery; Pericardial adhesion

Indexed keywords

ABRASION; ADHESION; BIODEGRADATION; BIODIVERSITY; CARDIOLOGY; DRUG INFUSION; FILMS; PATIENT MONITORING; TISSUE;

CARDIAC ADHESIONS; DEXAMETHASONE-LOADED FILMS; DRUG DISTRIBUTION; RABBIT MODEL;

METHANE;

COPOLYMER; DEXAMETHASONE; MACROGOL; POLY(LACTIDE CO ETHYLENE GLYCOL); POLYLACTIDE; UNCLASSIFIED DRUG;

ADHESION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABLE IMPLANT; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG DISTRIBUTION; EPICARDIUM; IMPLANT; NONHUMAN; PERICARDIECTOMY; RABBIT; STERNOTOMY; STERNUM;

ADHESIONS; ANIMALS; BIOCOMPATIBLE MATERIALS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DRUG IMPLANTS; MODELS, ANIMAL; PERICARDIAL EFFUSION; PERICARDIUM; POLYESTERS; POLYETHYLENE GLYCOLS; POSTOPERATIVE COMPLICATIONS; RABBITS;

EID: 33745938553     PISSN: 00219304     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30755     Document Type: Article

References (26)

1. Macmanus Q, Okies JE, Phillips SJ, Starr A. Surgical considerations in patients undergoing repeat median sternotomy. J Thorac Cardiovasc Surg 1975;69:138-143.
2. Saha K, McEwan W, Frizelle FA, Singh H. Limiting pericardial adhesions after coronary artery bypass: Experimental study. Asian Cardiovasc Thorac Ann 2004;12:61-64.
3. Hendrikx M, Mees U, Hill A, Egbert B, Coker G, Estridge T. Evaluation of a novel synthetic sealant for inhibition of cardiac adhesions and clinical experience in cardiac surgery proce-dures. Heart Surg Forum 2001;4:204-210.
4. Krause TJ, Zazanis G, Malatesta P, Solina A. Prevention of pericardial adhesions with N-O carboxymethylchitosan in the rabbit model. J Invest Surg 2001;14:93-97.
5. Malm T, Bowald S, Bylock A, Busch C. Prevention of postoperative pericardial adhesions by closure of the pericardium with absorbable polymer patches. An experimental study. J Thorac Cardiovasc Surg 1992;104:600-607.
6. Iliopoulos J, Cornwall GB, Evans RO, Manganas C, Thomas KA, Newman DC, Walsh WR. Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesions. J Surg Res 2004;118:144-153.
7. Amato JJ, Cotroneo JV, Galdieri RJ, Alboliras E, Antillon J, Vogel RL. Experience with the polytetrafluoroethylene surgical membrane for pericardial closure in operations for congenital cardiac defects. J Thorac Cardiovasc Surg 1989;97:929-934.
8. Robison RJ, Brown JW, Deschner WP, Highes B, King H. Prevention of pericardial adhesions with dextran 70. Ann Thorac Surg 1984;37:488-490.
9. Vander Salm TJ, Okike ON, Marsicano TH, Compton C, Espinoza E. Prevention of postoperative pericardial adhesions. An animal study. Arch Surg 1986;121:462-467.
10. Joyce DH, Cichon R, Muralidharan S, Gu J, McGrath LB. Alteration in pericardial adhesion formation following pretreatment with fibrin glue. J Appl Biomater 1991;2:269-271.
11. Hioki M, Iedokoro Y, Yamagishi S, Yamashita Y, Orii K, Hirano S, Hirata T, Masuda S, Kutukata N, Hisayoshi T, Tanaka S. Prevention of postoperative pericardial adhesions with a defibrinogenating agent. Int Surg 1998;83:11-14.
12. Wiseman DM, Kamp L, Linsky CB, Jochen RF, Pang RH, Scholz PM. Fibrinolytic drugs prevent pericardial adhesions in the rabbit. J Surg Res 1992;53:362-368.
13. Gallo I, Artinano E, Duran CG. Late clinical results with the use of heterologous pericardium for closure of the pericardial cavity. J Thorac Cardiovasc Surg 1985;89:709-712.
14. Laurencin CT, Elgendy H. The biocompatibility and toxicity of degradable polymeric materials: Implications for drug delivery. In: Domb AJ, editor. Polymeric Site-Specific Pharmacotherapy. New York: Wiley; 1994. p 27-46.
15. Kumar N, Ravikumar MN, Domb AJ. Biodegradable block copolymers. Adv Drug Deliv Rev 2001;53:23-44.
16. Danckwerts M, Fassihi A. Implantable controlled release drug delivery systems: A review. Drug Dev Ind Pharm 1991;17:1465-1502.
17. Perrin DA, English JP. Polyglycolide and polylactide. In: Domb AJ, Kost J, Wiseman DM, editors. Handbook of Biodegradable Polymers. Amsterdam: Harwood Academic; 1997. p 3-26.
18. Golomb G, Fishbein I, Banai S, Mishaly D, Moscovitz D, Gertz SD, Gazit A, Poradosu E, Levitzki A. Controlled delivery of a tyrphostin inhibits intimai hyperplasia in a rat carotid artery injury model. Atherosclerosis 1996;125:171-182.
19. Kohanna FH, Adams PX, Cunningham JN Jr, Spencer FC. Use of autologous fascia lata as a pericardial substitute following open-heart surgery. J Thorac Cardiovasc Surg 1977;74:14-19.
20. von Segesser L, Jornod N, Faidutti B. Repeat sternotomy after reconstruction of the pericardial sac with glutaraldehyde-preserved equine pericardium. J Thorac Cardiovasc Surg 1987;93:616-619.
21. Meus PJ, Wernly JA, Campbell CD, Takanashi Y, Pick RL, Zhao-Kun Q, Replogle RL. Long-term evaluation of pericardial substitutes. J Thorac Cardiovasc Surg 1983;85:54-58.
22. Nkere UU, Whawell SA, Sarraf CE, Schofield JB, O'Keefe PA. Pericardial substitution after cardiopulmonary bypass surgery: A trial of an absorbable patch. Thorac Cardiovasc Surg 1998;46:77-83.
23. Bennett SL, Melanson DA, Torchiana DF, Wiseman DM, Sawhney AS. Next-generation hydrogel films as tissue sealants and adhesion barriers. J Card Surg 2003;18:494-499.
24. Pitt CG, Gratzl MM, Jeffcoat AR, Zweidinger R, Schindler A. Sustained drug delivery systems. II. Factors affecting release rates from poly(E-caprolactone) and related biodegradable polyesters. J Pharm Sci 1979;68:1534-1538.
25. Yamaoka T, Tabata Y, Ikada Y. Comparison of body distribution of poly(vinyl alcohol) with other water-soluble polymers after intravenous administration. J Pharm Pharmacol 1995;47:479-486.
26. Okuyama N, Wang CY, Rose EA, Rodgers KE, Pines E, diZerega GS, Oz MC. Reduction of retrosternal and pericardial adhesions with rapidly resorbable polymer films. Ann Thorac Surg 1999;68:913-918.