Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model

Biocell

Volumn 30, Issue 1, 2006, Pages 9-13

  Sehgal, R ^a   Roy, S ^a   Kumar, Vijay L ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Allium cepa; Calotropis procera; Cyclophosphamide; Cytotoxic; Podophyllotoxin

Indexed keywords

ACETYLSALICYLIC ACID; CALOTROPIS PROCERA EXTRACT; CYCLOPHOSPHAMIDE; CYPROHEPTADINE; PODOPHYLLOTOXIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG INHIBITION; MITOSIS INDEX; MITOSIS INHIBITION; NONHUMAN; ONION; PLANT ROOT; ROOT GROWTH; ROOT LENGTH;

CALOTROPIS; CYTOTOXINS; DRUG EVALUATION, PRECLINICAL; LATEX; MERISTEM; MITOSIS; ONIONS; PLANT ROOTS; PODOPHYLLOTOXIN;

ALLIUM CEPA; CALOTROPIS PROCERA;

EID: 33745923821     PISSN: 03279545     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Al-Meshal IA (1987). Mitodepressive effect of (-)-cathinone, from Catha edulis (khat), on the meristematic region of Allium cepa root tips. Toxicon. 25: 451-454.
2. Badria FA, Houssein WE, Zaghloul MG, Halim AF (2001). Anti-mitotic activity of gossypol and gossypolone. Pharm Biol. 39: 120-126.
3. Bellosillo B, Pique M, Barragam M, Castano E, Villamor N, Colomer D, Montserrat E, Pons G, Gil J (1998). Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood. 92: 1406-1414.
4. Crook TR, Souhami RL, McLean AE (1986). Cytotoxicity, DNA cross-linking and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells. Cancer Res. 46: 5029-5034.
5. Gali-Muhtasib H, Bakkar N (2002). Modulating cell cycle: current applications and prospects for future drug development. Curr Cancer Drug Targets. 2: 309-336.
6. Gereis M, Burford Mason AP, Watkins SM (1987). Suppression of in vitro peripheral blood lymphocyte mitogenesis by cytotoxic drugs commonly used in the treatment of breast cancer: a comparative study. Agents Actions. 22: 324-9.
7. Hussein Ayoub SM, Kingstonb DGI (1981). Screening of plants used in Sudan folk medicine for anticancer activity. Fitoterapia. 52: 281-284.
8. Jordan MA, Thrower D, Wilson L (1992). Effects of vinblastine, Podophyllotoxin and nocodazole on mitotic spindles - Implications for the role of microtubule dynamics in mitosis. J Cell Sci. 102: 401-416.
9. Jordan MA (2002). Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr Med Chem Anti-Canc Agents. 2: 1-17.
10. Kirtikar and Basu (1935). Indian Medicinal plants, Vol. 1-8. Bishen Singh Mahendra Pal Singh, Dehradun, India.
11. Kiuchi F, Fukao Y, Maruyama T, Obata T, Tanaka M, Sasaki T, Mikage M, Haque ME, Tsuda Y (1998). Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.). Chem Pharm Bull (Tokyo). 46: 528-30.
12. Kupchan SM, Knox JR, Kelsey JE, Saenzrenauld JA (1964). Calotropin, a cytotoxic principle isolated from Asclepias curassavica L. Science. 146: 1685-1686.
13. Misra RR, Bloom SE (1991). Roles of dosage, pharmacokinetics, and cellular sensitivity to damage in the selective toxicity of cyclophosphamide towards B and T cells in development. Toxicology. 66: 239-256.
14. Mollinedo F, Gajate C (2003). Microtubules, microtubule-interfering agents and apoptosis. Apoptosis. 8: 413-450.
15. Powis G (1983). Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man. Drug Metab Rev. 14: 1145-1163.
16. Sangraula H, Dewan S, Kumar VL (2002). Evaluation of anti-inflammatory activity of latex of Calotropis procera in different models of inflammation. Inflammopharmacology. 9: 257-264.
17. Schwartz PS and Waxman DJ (2001). Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 60: 1268-1279.
18. Sharma CBSR (1983). Plant meristems as monitors of genetic toxicity of environmental chemicals. Curr Sci. 52: 1000-1002.
19. Shehab AS (1980). Cytological effects of medicinal plants in Qatar II. Mitotic effect of water extract of Teucrium pilosum on Allium cepa. Cytologia (Tokyo) 45: 57-64.
20. Smit HF, Woerdenbag HJ, Singh RH, Meulenbeld GJ, Labadie RP, Zwaving JH (1995). Ayurvedic herbal drugs with possible cytostatic activity. J Ethnopharmacol 47: 75-84.
21. Williams GO, Omoh LE (1996). Mitotic effects of the aqueous leaf extract of Cymbopogon citratus in Allium cepa root tips. Cytobios. 87: 161-168.
22. Umar A, Viner JL, Anderson WF, Hawk ET (2003). Development of COX inhibitors in cancer prevention and therapy. Am J Clin Oncol. 26: S48-57.
23. Zang KD, Eicke J, Stengel Rutkowski S, Zankl H (1975). Chromosome studies on human fibroblast cultures following exposure to cyproheptadin. Z Kinderheilkd. 118: 303-313.