Iptakalim alleviated the increase of extracellular dopamine and glutamate induced by 1-methyl-4-phenylpyridinium ion in rat striatum

Neuroscience Letters

Volumn 404, Issue 1-2, 2006, Pages 187-190

  Yang, Yan Jing ^a   Wang, Qing Min ^a   Hu, Li Fang ^a   Sun, Xiu Lan ^a   Ding, Jian Hua ^a   Hu, Gang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

1 Methyl 4 phenylpyridinium ion (MPP+); Dopamine; Glutamate; Iptakalim; Microdialysis

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 3,4 DIHYDROXYPHENYLACETIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; DOPAMINE; GLUTAMIC ACID; HOMOVANILLIC ACID; ION; IPTAKALIM; POTASSIUM CHANNEL STIMULATING AGENT;

AMINO ACID BRAIN LEVEL; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANNULATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EXTRACELLULAR FLUID; IMPLANTATION; INFUSION; MALE; METABOLITE; MICRODIALYSIS; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CORPUS STRIATUM; DOPAMINE; EXTRACELLULAR SPACE; GLUTAMIC ACID; KINETICS; MALE; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33745922110     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.05.042     Document Type: Article

References (29)

1. Blandini F., Nappi G., Tassorelli C., and Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson's disease. Prog. Neurobiol. 62 (2000) 63-88
2. Blondeau N., Plamondon H., Richelme C., Heurteaux C., and Lazdunski M. KATP channel openers, adenosine agonists and epileptic preconditioning are stress signals inducing hippocampal neuroprotection. Neuroscience 100 (2000) 465-474
3. 2 induced cytotoxicity in pheochromocytoma (PC12) cells. China J. Clin. Pharmacol. Ther. 10 (2005) 377-381 (Chinese)
4. +, a metabolite of MPTP, by brain synaptosomes. Biochem. Biophys. Res. Commun. 128 (1985) 1228-1232
5. +. Free Radic. Biol. Med. 13 (1992) 581-583
6. Chiueh C.C., Wu R.M., Mohanakumar K.P., Sternberger L.M., Krishna G., Obata T., and Murphy D.L. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Ann. N.Y. Acad. Sci. 738 (1994) 25-36
7. Dexter D.T., Carter C.J., Wells F.R., Javoy-Agid F., Agid Y., Lees A., Jenner P., and Marsden C.D. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J. Neurochem. 52 (1989) 381-389
8. +) cause rapid ATP depletion in isolated hepatocytes. Biochem. Biophys. Res. Commun. 137 (1986) 310-315
9. Halliwell B. Reactive oxygen species and central nervous system. J. Neurochem. 59 (1992) 1609-1623
10. Hazell A.S., Itzhak Y., Liu H., and Norenberg M.D. 1-Methyl-4-phenyl-1,2,3,6- tetrahydropurikine (MPTP) decreases glutamate uptake in cultured astrocytes. J. Neurochem. 68 (1997) 2216-2219
11. Hu L.F., Wang S., Shi X.R., Yao H.H., Sun Y.H., Ding J.H., Liu S.Y., and Hu G. ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level. J. Neurochem. 94 (2005) 1570-1579
12. Leist M., Volbracht C., Fava E., and Nicotera P. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. Mol. Pharmacol. 54 (1998) 789-801
13. Matute C., Alberdi E., and Ibarretxe G. Excitotoxicity in glial cells. Eur. J. Pharmacol. 447 (2002) 239-246
14. Nass R., Miller D.M., and Blakely R.D. C. elegans: a novel pharmaco-genetic model to study Parkinson's disease. Parkinsonism Relat. Disord. 7 (2001) 185-191
15. +) in rat striatum. Biochim. Biophys. Acta 1568 (2001) 171-175
16. G. Paxinos, C Watson, The Rat Brain in Stereotaxic Coordinates, 2nd edition, San Diego: Academic Press, 1986.
17. Ramsay R.R., Salach J.I., Dadgar J., and Singer T.P. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochem. Biophy. Res. Commun. 135 (1986) 269-275
18. +. Eur. J. Pharmacol. 126 (1986) 345-346
19. Sayre L.M. Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol. Lett. 48 (1989) 121-129
20. Sonsalla P.K., Albers D.S., and Zeevalk G.D. Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism. Amino Acids 14 (1998) 69-74
21. + neurotoxicity by N-methyl-d-aspartate antagonists. Nature 349 (1991) 414-418
22. Wang H. ATP-sensitive potassium channel as a new target for development of antihypertensive drugs. Acta Pharmacologica Sinica 19 (1998) 257-267
23. Wang H., Zhang Y.L., Tang X.C., Feng H.S., and Hu G. Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain. Mol. Pharmacol. 66 (2004) 1-9
24. Wang S., Hu L.F., Yang Y., Ding J.H., and Hu G. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease?. Neuropharmacology 48 (2005) 984-992
25. Yang Y., Liu X., Ding J.H., Sun J., Long Y., Wang F., Yao H.H., and Hu G. Effects of Iptakalim on rotenone-induced cytotoxicity and dopamine release from PC12 cells. Neurosci. Lett. 366 (2004) 53-57
26. Yang Y.L., Meng C.H., Ding J.H., He H.R., Ellsworth K., Wu J., and Hu G. Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models. Brain Res. 1049 (2005) 80-88
27. + channels in pancreatic, cardiac, and vascular smooth muscle cells. Am. J. Physiol. 274 (1998) 25-37
28. Zhang Y., and Hu G. Iptakalim enhances astrocytic glutamate uptake activity. Yao. Xue. Xue. Bao. 39 (2004) 980-983 (Chinese)
29. Zuddas A., Oberto G., Vaglini F., Fascetti F., Fornaiand F., and Corsini G.U. MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates. J. Neurochem. 59 (1992) 733-739