Prion-induced amyloid heart disease with high blood infectivity in transgenic mice

Science

Volumn 313, Issue 5783, 2006, Pages 94-97

  Trifilo, Matthew J ^a   Yajima, Toshitaka ^b   Gu, Yusu ^b   Dalton, Nancy ^b   Peterson, Kirk L ^b   Race, Richard E ^c   Meade White, Kimberly ^c   Portis, John L ^c   Masliah, Eliezer ^d   Knowlton, Kirk U ^b   Chesebro, Bruce ^c   Oldstone, Michael B A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOMEDICAL ENGINEERING; BRAIN; DISEASE CONTROL; IMMUNOLOGY; NEUROLOGY; PROTEINS;

EXTRANEURAL MANIFESTATIONS; GLYCOPHOSPHATYDYLINOSITOL MEMBRANE; HEART DISEASE; NONTRANSGENIC RECIPIENTS;

BLOOD;

AMYLOID; GLYCOSYLPHOSPHATIDYLINOSITOL; PRION PROTEIN;

BLOOD; CARDIOVASCULAR DISEASE; PRION DISEASE; RODENT;

AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART DISEASE; HEART MUSCLE COMPLIANCE; IMMUNOBLOTTING; INFECTION; INOCULATION; MEMBRANE; MOUSE; NONHUMAN; PRION; PRIORITY JOURNAL; SCRAPIE; SEPSIS; TRANSGENIC MOUSE;

AMYLOID; AMYLOIDOSIS; ANIMALS; BLOTTING, WESTERN; CORONARY VESSELS; DISEASE MODELS, ANIMAL; GLYCOSYLPHOSPHATIDYLINOSITOLS; HEART CATHETERIZATION; HEART DISEASES; HEART FUNCTION TESTS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROCIRCULATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; PRPC PROTEINS; PRPSC PROTEINS; SCRAPIE; STAINING AND LABELING; TIME FACTORS;

MUS MUSCULUS;

EID: 33745910558     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1128635     Document Type: Article

References (28)

1. H. Fraser, A. G. Dickinson, Nature 226, 462 (1970).
2. S. B. Prusiner, Science 216, 136 (1982).
3. P. J. Bosque et al., Proc. Natl. Acad. Sci. U.S.A. 99, 3812 (2002).
4. M. Heikenwalder et al., Science 307, 1107 (2005).
5. A. Alperovitch et al., Lancet 353, 1673 (1999).
6. D. C. Gajdusek, C. J. Gibbs Jr., Res. Publ. Assoc. Res. Nerv. Ment. Dis. 44, 254 (1968).
7. C. J. Gibbs Jr. et al., Science 161, 388 (1968).
8. M. R. Scott et al., Proc. Natl. Acad. Sci. U.S.A. 96, 15137 (1999).
9. C. A. Llewelyn et al., Lancet 363, 417 (2004).
10. A. H. Peden, M. W. Head, D. L. Ritchie, J. E. Bell, J. W. Ironside, Lancet 364, 527 (2004).
11. F. Houston, J. D. Foster, A. Chong, N. Hunter, C. J. Bostock, Lancet 356, 999 (2000).
12. P. Casaccia, A. Ladogana, Y. G. Xi, M. Pocchiari, Arch. Virol. 108, 145 (1989).
13. M. C. Clarke, D. A. Haig, Vet. Rec. 80, 504 (1967).
14. S. C. Collis, R. H. Kimberlin, G. C. Millson, J. Comp. Pathol. 89, 389 (1979).
15. J. Tateishi, Y. Sato, M. Koga, H. Doi, M. Ohta, Acta Neuropathol. (Berlin) 51, 127 (1980).
16. P. Brown et al., Transfusion 39, 1169 (1999).
17. P. Brown et al., Transfusion 38, 810 (1998).
18. L. Cervenakova et al., Transfusion 43, 1687 (2003).
19. K. Holada et al., J. Virol 76, 4649 (2002).
20. Y. Kuroda, C. J. Gibbs Jr., H. L. Amyx, D. C. Gajdusek, Infect. Immun. 41, 154 (1983).
21. B. Chesebro et al., Science 308, 1435 (2005).
22. T. L. Bale et al., Proc. Natl. Acad. Sci. U.S.A. 101, 3697 (2004).
23. W. H. Gaasch, JAMA 271, 1276 (1994).
24. M. R. Zile, D. L. Brutsaert, Circulation 105, 1387 (2002).
25. J. Castilla, P. Saa, C. Soto, Nat. Med. 11, 982 (2005).
26. M. L. Ashwath, S. J. Dearmond, T. Culclasure, Arch. Intern. Med. 165, 338 (2005).
27. C. Herzog et al., J. Virol. 79, 14339 (2005).
28. We acknowledge the technical assistance of A. Andaya, J. Garber, and F. Last. This research was supported by NIH grants AG04342 (M.B.A.O. and M.J.T.) and 5R01HL66424-04 (K.U.K.) and by NIH training grant NS041219-05 (M.J.T.).