Preparation and characterization of pH sensitive semi-interpenetrating network hydrogel based on methacrylic acid, Bovine Serum Albumin (BSA), and PEG

Journal of Polymer Research

Volumn 13, Issue 5, 2006, Pages 349-355

  Chao, Guotao ^a,b   Deng, Hongxin ^a   Huang, Qiong ^c   Jia, Wenjuan ^b   Huang, Wanxia ^b   Gu, Yingchun ^b   Tan, Heping ^d   Fan, Linyu ^a   Liu, Caibing ^b   Huang, Anliang ^a   Lei, Ke ^a   Gong, Changyang ^a   Tu, Mingjing ^b   Qian, Zhiyong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c GUANGXI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d NATIONAL INSTITUTE OF MEASUREMENT AND TESTING TECHNOLOGY   (China)

Author keywords

Hydrogel; Macromolecular drug delivery; Responsive delivery systems; Water absorption

Indexed keywords

CARBOXYLIC ACIDS; CROSSLINKING; FREE RADICAL POLYMERIZATION; PH EFFECTS; SENSITIVITY ANALYSIS; ULTRAVIOLET RADIATION; WATER ABSORPTION;

MACROMOLECULAR DRUG DELIVERY; PH SENSITIVITY; RESPONSIVE DELIVERY SYSTEMS;

HYDROGELS;

EID: 33745892909     PISSN: 10229760     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10965-006-9050-1     Document Type: Article

References (17)

1. K. Y. Lee and D. J. Mooney, Hydrogels for tissue engineering, Chem. Rev., 101(7), 1869-1879 (2001).
2. Y. Qiu and K. Park, Environment-sensitive hydrogels for drug delivery, Adv. Drug Del. Rev., 53, 321-339 (2001).
3. K. T. Nguyen and J. L. West, Photopolymerizable hydrogels for tissue engineering applications, Biomaterials, 23, 4307-4314 (2002).
4. R. K. Drumraond, J. Klier, J. A. Alameda and N. A. Peppas, Preparation of poly(methacrylic acid-g-ethylene oxide) microspheres, Macromolecules, 22, 3816-3818 (1989).
5. M. Torres-Lugo, M. Garcia, R. Record and N. A. Peppas, Physicochemical behavior and cytotoxic effects of P(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins, J. Control. Release, 80, 197-205 (2002).
6. M. Torres-Lugo and N. A. Peppas, Molecular dosing and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin, Macromolecules, 32, 6646-6651 (1999).
7. H. Ichikawa, M. Torres-Lugo and N. A. Peppas, Novel pH-sensitive hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin transport effect in caco-2 cell mono-layers, AAPS Pharm. Sci., S3287 (2000).
8. D. S. Bag, S. Alam and G. N. Mathur, Terpolymer smart gels: synthesis and characterizations, Smart Materials Structures, 13, 1258-1262 (2004).
9. S. L. Zhou, S. Matsumoto, H. D. Tian, H. Yamane, A. Ojida, S. Kiyonaka and I. Hamachi, PH-responsive shrinkage/swelling of a supramolecular hydrogel composed of two small amphiphilic molecules, Chem. Euro. J., 11, 1130-1136 (2005).
10. X. C. Xiao, L. Y. Chu, W. M. Chen, S. Wang and Y. Li, Positively thermo-sensitive monodisperse core-shell microspheres, Adv. Funct. Mater., 13, 847-852 (2003).
11. P. Markland, Y. Zhang, G. L. Amidon and V. C. Yang, A pH- and ionic strength-responsive polypeptide hydrogel: synthesis, characterization, and preliminary protein release studies, J. Biomed. Mater. Res., 47, 595-602 (1999).
12. K. R. Kamath and K. Park, Biodegradable hydrogels in drug delivery, Adv. Drug Del. Rev., 11, 59-84 (1993).
13. S. Murdan, Electro-responsive drug delivery from hydrogels, J. Control. Release, 92, 1-17 (2003).
14. W. F. Lee and R. J. Chiu, Thermoreversible hydrogels. XVIII. Synthesis, swelling characteristics, and diffusion behaviors of porous, ionic, thermosensitive hydrogels, J. Appl. Potym. Sci., 90, 2214-2223 (2003).
15. D. Saraydin, E. Karadag and O. Guven, Acrylamide/Maleic acid hydrogels, Polym, Adv. Technol., 6, 719-726 (1995).
16. H. Xu, P. T. Ding, G. Wei, G. S. Zhou and J. M. Zheng, Equilibrium swelling and solute diffusion characteristics of poly(methacrylic acid-co-poloxamer) hydrogel, J. Chin. Pharm. Sci., 10(4), 203-207 (2001).
17. B. Kim, K. L. Flamme and N. A. Peppas, Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery, J. Appl. Polym. Sci., 89, 1606-1613 (2003).