Expression of Vicia villosa agglutinin (VVA)-binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: Is atypical MUC1 bearing Tn antigen a receptor of VVA?

Breast Cancer Research and Treatment

Volumn 98, Issue 1, 2006, Pages 31-43

  Kawaguchi, Takanori ^a   Takazawa, Hiroshi ^b   Imai, Shunsuke ^c   Morimoto, Junji ^d   Watanabe, Takanori ^a   Kanno, Masahiko ^a   Igarashi, Seiji ^e  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION CHIBA MEDICAL CENTER   (Japan)

^c Nara Pref Inst of Public Health   (Japan)

^d OSAKA MEDICAL COLLEGE   (Japan)

^e TOCHIGI CANCER CENTER   (Japan)

Author keywords

Breast cancer; Lymphatic metastasis; MUC1; Tn antigen; Vicia villosa lectin

Indexed keywords

GALACTOSAMINE; GLYCOPROTEIN; MONOCLONAL ANTIBODY; MUCIN 1; N ACETYLGALACTOSAMINE ALPHA1 O SERINE; TN ANTIGEN; UNCLASSIFIED DRUG; VICIA VILLOSA AGGLUTININ BINDING GLYCOPROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INVASION; CANCER STAGING; CONTROLLED STUDY; DENATURATION; FEMALE; FROZEN SECTION; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; INVASIVE CARCINOMA; LYMPH NODE METASTASIS; METASTASIS POTENTIAL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BREAST NEOPLASMS; CA-15-3 ANTIGEN; CARBOHYDRATES; CELL PROLIFERATION; EPITOPES; FEMALE; GLYCOPROTEINS; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; MUCIN-1; PLANT LECTINS;

EID: 33745886837     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-005-9115-6     Document Type: Article

References (51)

1. Sharon N, Lis H: Lectins: cell-agglutinating and sugar-specific proteins. Science 177: 949-959, 1972
2. Feizi T: Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature 314: 53-57, 1985
3. Dabelsteen E: Cell surface carbohydrates as prognostic markers in human carcinomas. J Pathol 179: 358-369, 1996
4. Hakomori S-I: Tumor malignancy defined by aberrant glycosylation and sphingo (glycol) lipid metabolism. Cancer Res 56: 5309-5318, 1996
5. Dennis JW: Changes in glycosylation associated with malignant transformation and tumor progression. Cell Surface Carbohydrates and Cell Development. CRC Press, Boca Raton, LA, 1992 161-194
6. Gorelik E, Galili U, Raz A: On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis. Cancer Metastasis Rev 20: 245-277, 2001
7. Kawaguchi T: Cancer metastasis: characterization and identification of the behavior of metastatic tumor cells and the cell adhesion molecules, including carbohydrates. Curr Drug Targets Cardiovasc Haematol Disord 5: 39-64, 2005
8. Kellokumpu IH: Differences in lectin reactivities of cellular glycoconjugates between primary human colorectal carcinomas and their metastases. Cancer Res 46: 4620-4625, 1986
9. Nishiyama T, Matsumoto Y, Watanabe H, Fujiwara M, Sato S: Detection of Tn antigen with Vicia villosa agglutinin in urinary bladder cancer: its relevance to the patient's clinical course. J Natl Cancer Inst 78: 1113-1118, 1987
10. Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS: Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer. Cancer Res 49: 197-204, 1989
11. Itzkowitz S, Kjeldsen T, Friera A, Hakomori S-I, Yang U-S, Kim YS: Expression of Tn, sialosyl Tn, and T antigens in human pancreas. Gastroenterology 100: 1691-1700, 1991
12. Hirao T, Sakamoto Y, Kamada M, Hamada S, Aono T: Tn antigen, a marker of potential for metastasis of uterine cervix cancer cells. Cancer 72: 154-159, 1993
13. Hamada S-I, Furumoto H, Kamada M, Hirao T, Aono T: High expression rate of Tn antigen in metastatic lesions of uterine cervical cancers. Cancer Lett 74: 167-173, 1993
14. Terasawa K, Furumoto H, Kamada M, Aono T: Expression of Tn and sialyl-Tn antigens in the neoplastic transformation of uterine cervical epithelial cells. Cancer Res 56: 2229-2232, 1996
15. Abe M, Suzuki O, Tasaki K, Tominaga K, Wakasa H: Analysis of lectin binding properties on human Burkitt's lymphoma cell lines that show high spontaneous metastasis to distant organs in SCID mice: the binding sites for soybean agglutinin lectin masked by sialylation are closely associated with metastatic lymphoma cells. Pathol Int 46: 977-983, 1996
16. Fujiu K, Kawaguchi T, Suzuki H, Kushida M, Kanno R, Oishi A, Inoue H, Motoki R: Expression of mucin type core carbohydrates in squamous cell carcinoma of the lung and its relationship to metastasis and outcome. Lung Cancer 37: 301-311, 1997 (in Japanese)
17. Konno A, Hoshino Y, Terashima S, Motoki R, Kawaguchi T: Carbohydrate expression profile of colorectal cancer cells is relevant to metastatic pattern and prognosis. Clin Exp Metastasis 19: 61-70, 2002
18. Wu AM: Polyvalency of Tn (GalNAcα1 → Ser/Thr) glycotope as a critical factor for Vicia villosa B4 and glycoprotein interactions. FEBS Lett 562: 51-58, 2004
19. 4). FEBS Lett 312: 208-212, 1992
20. Tollefsen S, Kornfeld R: Isolation and characterization of lectins from Vicia villosa. two distinct carbohydrate binding activities are present in seed extracts. J Biol Chem 258: 5165-5171, 1983
21. 4 lectin from Vicia villosa seeds interacts with N-acetylgalactosamine residues α-linked to serine or threonine residues in cell surface glycoproteins. J Biol Chem 258: 5172-5176, 1983
22. Kaladas PM, Kabat EA, Kimura A, Ersson B: The specificity of the combining site of the lectin from Vicia villosa seeds which reacts with cytotoxic T-lymphoblasts. Mol Immunol 18: 969-977, 1981
23. Tollefsen S, Kornfeld R: The B4 lectin from Vicia villosa seeds interacts with N-acetylgalactosamine residues on erythrocytes with blood group Cad specificity. Biochem Biophys Res Commun 123: 1099-1106, 1984
24. Qian R, Shi WX, Shen ZM, Sun C: A mannose-specific lectin from Vicia villosa seeds. Biochim Biophys Acta 28: 61-68, 1994
25. Japanese Breast Cancer Society: The general rules for clinical and pathological recording of breast cancer. Jpn J Surg 19: 612-32, 1989
26. Koyama S, Terashima S, Takano Y, Ohori T, Inoue J, Motoki R, Kawaguchi T: p53 protein expression of carcinoma cells associated with metastasis and prognosis in gastric carcinomas: a clinicopathological study. Fukushima Igaku Zasshi 47: 131-142, 1997
27. Hsu S-M, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29: 577-580, 1981
28. Matsushita Y, Yamamoto N, Shirahama H, Tanaka S. Yonezawa S, Yamori T, Irimura T, and Sato E: Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastasis. Jpn J Cancer Res 86: 1060-1067, 1995
29. Kawaguchi T, Ono T, Wakabayashi H, Igarashi, S: Cell surface laminin-like substances and laminin-related carbohydrates of rat ascites hepatoma AH7974 and its variants with different lung-colonizing potential. Clin Exp Metastasis 12: 203-212, 1994
30. Kawaguchi T: Vicia villosa agglutinin (lectin)-binding carbohydrate(s) is expressed in atypical MUC1, serotransferrin and immunoglobulin of rat ascites hepatoma AH109A cells with lymphatic metastasis propensity. Proc Am Assoc for Cancer Res 46: 52, 2005
31. Kawaguchi T, Takazawa H, Imai S, Morimoto J, Watanabe T: Lack of polymorphism in MUC1 tandem repeats in cancer cells is related to breast cancer progression in Japanese women. Breast Cancer Res Treat 92: 223-230, 2005
32. Swallow DM, Griffiths B, Bramwell M, Wiseman G, Burchell J: Detection of the urinary 'PUM' polymorphism by the tumour-binding monoclonal antibodies Ca1, Ca2, Ca3, HMFG1, and HMFG2. Dis Markers 4: 247-254, 1986
33. Kawaguchi T, Nakamura K: Analysis of the lodgement and extravasation of tumor cells in experimental models of hematogenous metastasis. Cancer Metastasis Rev 5: 77-94, 1986
34. Avichezer D, Arnon R: Differential reactivities of the Arachis hypogaea (peanut) and Vicia villosa B4 lectins with human ovarian carcinoma cells, grown either in vitro or in vivo xenograft model. FEBS Lett 395: 103-108, 1996
35. Springer GF: T and Tn, general carcinoma autoantigens. Science 224: 1198-1206, 1984
36. Springer GF, Taylor CR, Howard DR, Tegtmeyer H, Desai PR, Murthy SM, Felder B, Scanlon EF: Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera. Cancer 55: 561-569, 1985
37. Tsuchiya A, Kanno M, Kawaguchi T, Endo Y, Zhang G-J, Ohtake T, Kimijima I: Prognostic relevance of Tn expression in breast cancer. Breast Cancer 6: 175-180, 1999
38. Nakada H, Numata Y, Inoue M, Tanaka N, Kitagawa H, Funakoshi U, Fukui S, Yamashina I: Elucidation of an essential structure recognized by an anti-GalNAcα-Ser (Thr), monoclonal antibody (MLS128). J Biol Chem 266: 12402-12405, 1991
39. Nakada H, Inoue M, Numata Y, Tanaka N, Funakoshi I, Fukui S, Mellors A, Yamashina I: Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS128). Proc Natl Acad Sci USA 90: 2495-2499, 1993
40. Oppezzo P, Osinaga E, Tello D, Bay S, Cantacuzene D, Irigoin F, Ferreira A, Roseto A, Cayota A, Alzari P, Pritsch O: Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen. Hybridoma 19: 229-239, 2000
41. Schol DJ, Meulenbroek MFA, Snijdewint FGM, von Mensdorff-Pouilly S, Verstraeten RA, Murakami F, Kenemans P, Hilgers J: 'Epitope fingerprinting' using overlapping 20-mer peptides of the MUC1 tandem repeat sequence. Tumor Biol 19 (suppl 1): 35-45, 1998
42. Houghton AN, Lloyd KO: Struck in the MUC on the long and winding road. Nature Med 4: 270-271, 1998
43. Patton S, Gendler SJ, Spicer AP: The epithelial mucin, MUC1, of milk, mammary gland and other tissues. Biochim Biophys Acta 1241: 407-424, 1995
44. Baldus SE, Engelmann K, Hanisch F-G: MUC1 and the MUCs: a family of human mucins with impact in cancer biology. Crit Rev Clin Lab Sci 41: 189-231, 2004
45. Burchell J, Gendler S, Taylor-Papadimitriou J, Girling A, Lewis A, Millis R, Lamport D: Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res 47: 5476-5482, 1987
46. Baruch A, Hartmann M-I, Yoeli M, Adereth Y, Greenstein S, Stadler Y, Skornik Y, Zaretsky J, Smorodinsky NI, Keydar I, Wreshner DH: The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein. Cancer Res 59: 1552-1561, 1999
47. Kohlgraf KG, Gawron AJ, Higashi M, Meza JL, Burdick MD, Kitajima S, Kelly DL, Caffrey TC, Hollingsworth MA: Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Cancer Res 63: 5011-5020, 2003
48. Levitin F, Baruch A, Weiss M, Stiegman K, Hartmann M-I, Yoeli-Lerner M, Ziv R, Zrihan-Licht S, Shina S, Gat A, Lifschitz B, Simha M, Stadler Y, Cholostory A, Gil B, Greaves D, Keydar I, Zaretsky J, Smorodinsky N, Wreschner DH: A novel protein derived from the MUC1 gene by alternative splicing and frame-shifting. J Biol Chem 280: 10655-10663, 2005
49. Alpaugh ML, Tomlinson JS, Shao Z-M, Barsky SH: A novel human xenograft model of inflammatory breast cancer. Cancer Res 59: 5079-5084, 1999
50. Charafe-Jauffret E, Tarpin C, Bardou V-J, Bertucci F, Ginester C, Braud A-C, Puig B, Geneix J, Hassoun J, Bimbaum D, Jacquemier J, Viens P: Immunophenotypic analysis of inflammatory breast cancers: identification of an 'inflamamtory signature'. J Pathol 202: 265-273, 2004
51. Rahn JJ, Shen Q, Mah BK, Hugh JC: MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1. J Biol Chem 279: 29386-29390, 2004