Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells

Journal of Ethnopharmacology

Volumn 107, Issue 1, 2006, Pages 143-150

  Li, Runping ^a   Guo, Meili ^a   Zhang, Ge ^a   Xu, Xiongfei ^a   Li, Quan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cerebrovascular endothelial cell; eNOS; Hypoxia reoxygenation; Ischemia reperfusion; Neuroprotection; Nicotiflorin

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; NICOTIFLORIN;

ANIMAL CELL; ARTICLE; BRAIN BLOOD VESSEL; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL CULTURE; ENDOTHELIUM CELL; ENZYME ACTIVITY; HYPOXIA; MALE; NEUROLOGIC DISEASE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION INJURY; UPREGULATION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; BRAIN; BRAIN ISCHEMIA; DNA PRIMERS; ENDOTHELIUM, VASCULAR; FLAVONOIDS; MALE; NITRIC OXIDE SYNTHASE TYPE III; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; UP-REGULATION;

FLOS;

EID: 33745862382     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.04.024     Document Type: Article

References (42)

1. Abbott N.J., Hughes C.C., Revest P.A., and Greenwood J. Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. Journal of Cell Science 103 (1992) 23-37
2. Ahmad M., Gilani A.ul.H., Aftab K., and Ahmad V.U. Effects of kaempferol-3-O-rutinoside on rat blood pressure. Phytotherapy Research 7 (1993) 314-316
3. Arnet U.A., McMillan A., Dinerman J.L., Ballermann B., and Lowenstein C.J. Regulation of endothelial nitric-oxide synthase during hypoxia. Journal of Biological Chemistry 271 (1996) 15069-15073
4. Bie X.D. Clinical observation on treatment of traumatic intracranial hematoma by Flos carthami combined with radix Acanthopanacis senticosi injection. Chinese Journal of Integrative Medicine 23 (2003) 296-297
5. Cardenas L.C., Rodriguez J., Villaverde M.C., Riguera R., Cadena R., and Otero J.A. The analgesic activity of Hedyosmum bonplandianum: flavonoid glycosides. Planta Medica 59 (1993) 26-27
6. Dajas F., Rivera-Megret F., Blasina F., Arredondo F., Abin-Carriquiry J.A., Costa G., Echeverry C., Lafon L., Heizen H., Ferreira M., and Morquio A. Neuroprotection by flavonoids. Brazilian Journal of Medical and Biological Research 36 (2003) 1613-1620
7. Dalkara T., and Moskowitz M.A. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathology 4 (1994) 49-57
8. Dawson D.A. Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome. Cerebrovascular and Brain Metabolism Review 6 (1994) 299-324
9. Endres M., Laufs U., Huang Z., Nakamura T., Huang P., Moskowitz M.A., and Liao J.K. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of USA 95 (1998) 8880-8895
10. Faraci F.M. Endothelium-derived vasoactive factors and regulation of the cerebral circulation. Neurosurgery 33 (1993) 648-658
11. Forstermann U., Boissel J.P., and Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB Journal 12 (1998) 773-790
12. Fukumoto H., Yamaki M., Isoi K., and Ishiguro K. Antianaphylactic Effects of the Principal compounds from the white Petals of Impatiens balsamina L. Phytotherapy Research 10 (1996) 202-206
13. Furchgott R.F., and Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 (1980) 373-376
14. Guo, M.L., Zhang, G., 2004. A kind of method with preparation of kaempferol derivatives (in Chinese). State Patent for Invention of PR China. Application number: 200410054147.5. Publicity number: CN1629175A.
15. Hattori M., Huang X.L., Che Q.M., Kawata Y., Tezuka Y., Kikuchi T., and Namba T. 6-hydroxykaempferol and its glycosides from Carthamus tinctorius petals. Phytochemistry 31 (1992) 4001-4004
16. Huang P.L., Huang Z., Mashimo H., Bloch K.D., Moskowitz M.A., Bevan J.A., and Fishman M.C. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377 (1995) 239-242
17. Huang Z., Huang P.L., Ma J., Meng W., Ayata C., Fishman M.C., and Moskowitz M.A. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-l-arginine. Journal of Cerebra Blood Flow Metabolism 16 (1996) 981-987
18. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., and Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265 (1994) 1883-1885
19. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends in Neuroscience 20 (1997) 132-139
20. Ignarro L.J. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annual Review of Pharmacology and Toxicology 30 (1990) 535-560
21. Isayama K., Pitts L.H., and Nishimura M.C. Evaluation of 2,3,5-triphenyltetrazolium chloride staining to delineate rat brain infarcts. Stroke 22 (1991) 1394-1398
22. Kim M.N., Le. Scao-Bogaert F., and Paris M. Flavonoids from Carthamus tinctorius flowers. Planta Medica 58 (1992) 285-286
23. Kimura M., Dietrich H.H., and Dacey Jr. R.G. Nitric oxide regulates cerebral arteriolar tone in rats. Stroke 25 (1994) 2227-2233
24. Kis B., Szabo C.A., Pataricza J., Krizbai I.A., Mezei Z., Geese A., Telegdy G., Papp J.G., and Deli M.A. Vasoactive substances produced by cultured rat brain endothelial cells. European Journal of Pharmacology 368 (1999) 35-42
25. Kubes P., Suzuki M., and Granger D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proceedings of the National Academy of Sciences of USA 88 (1991) 4651-4655
26. Laufs U., La Fata V.L., and Liao J.K. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. Journal of Biological Chemistry 272 (1997) 31725-31729
27. Liu Y.T., Murong S.X., and Xu G.Y. Effects of Flos Carthami on beta-endorphin levels in brain regions of rats with cerebral ischemia. Chinese Journal of Integrative Medicine 17 (1997) 169-170
28. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniotomy in rats. Stroke 20 (1989) 84-91
29. Luo J., Fang Z.P., Zhou L.M., and Lai S.T. Efects of Carthamus tinctorius injection on bcl-2, caspase-3 expression related to neurons apoptosis after local cerebral ischemia. Journal of Chinese Materia Medica 29 (2004) 977-980
30. McQuillan L.P., Leung G.K., Marsden P.A., Kostyk S.K., and Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. American Journal of Physiology 267 (1994) H1921-H1927
31. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacology Review 52 (2000) 673-751
32. Palmer R.M., Ferrige A.G., and Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327 (1987) 524-526
33. Plumb G.W., Price K.R., and Williamson G. Antioxidant properties of flavonol glycosides from tea. Redox Report 4 (1999) 13-16
34. Radi R., Rodriguez M., Castro L., and Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Archives of Biochemistry and Biophysics 308 (1994) 89-95
35. Rudic R.D., Shesely E.G., Maeda N., Smithies O., Segal S.S., and Sessa W.C. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. The Journal of Clinical Investigation 101 (1998) 731-736
36. Radomski M.W., Palmer R.M., and Moncada S. An l-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proceedings of the National Academy of Sciences of USA 87 (1990) 5193-5197
37. Shibata M., Kumar S.R., Amar A., Fernandez J.A., Hofman F., Griffin J.H., and Zlokovic B.V. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 103 (2001) 1799-1805
38. Siow Y.L., Choy P.C., and Leung W.M. Effect of Flos carthami on stress-activated protein kinase activity in the isolated reperfused rat heart. Molecular Cell Biochemistry 207 (2000) 41-47
39. Song Z.J., Yang G.T., Lu D.Q., and Wang D.X. Influence of hypoxia-reoxygenation on nitric oxide synthesis III gene expression in cultured cerebral arterial endothelial cell. Chinese Critical Care Medicine 15 (2003) 535-537
40. Swanson R.A., Morton M.T., Tsao W.G., Savalos R.A., Davidson C., and Sharp F.R. A semiautomated method for measuring brain infarct volume. Journal of Cerebra Blood Flow Metabolism 10 (1990) 290-293
41. Zhang G., Guo M.L., Zhang H.M., Sao F., Sun L.N., and Chen W.S. Study on the chemical constituents of Flos Carthami (1). Academic Journal of Second Military Medical University 23 (2002) 109-110
42. Zhang G., Guo M.L., Zhang H.M., and Su Z.W. Study on the chemical constituents of Flos Carthami (11). Academic Journal of Second Military Medical University 26 (2005) 220-221