Sterility assessment of multiple use botulinum A exotoxin vials: A prospective simulation

Journal of the American Academy of Dermatology

Volumn 55, Issue 2, 2006, Pages 272-275

  Alam, Murad ^a,b   Yoo, Simon S ^a   Wrone, David A ^a   White, Lucile E ^a   Kim, John Y S ^c  

^a Section of Cutaneous and Aesthetic Surgery   (United States)

^b Department of Otolaryngology ^*  (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL ALCOHOL; BOTULINUM TOXIN A; PRESERVATIVE; THIOGLYCOLIC ACID;

ARTICLE; CONTAINER; CONTROLLED STUDY; DRUG CONTAMINATION; DRUG STORAGE; FREEZING; HUMAN; LABORATORY TEST; MICROBIAL CONTAMINATION; MICROBIOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RISK; SIMULATION; TIME;

BOTULINUM TOXIN TYPE A; DRUG CONTAMINATION; DRUG PACKAGING; DRUG STORAGE; HUMANS; NEUROMUSCULAR AGENTS; PROSPECTIVE STUDIES; RANDOM ALLOCATION; REFRIGERATION; RISK FACTORS; STERILIZATION; TIME FACTORS;

EID: 33745854818     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2006.01.019     Document Type: Article

References (5)

1. Botox Cosmetic. [package insert] (2002), Allergan Inc, Irvine, CA
2. Alam M., Dover J.S., and Arndt K.A. Pain associated with injection of botulinum A exotoxin reconstituted using isotonic sodium chloride with and without preservative: a double-blind randomized controlled trial. Arch Dermatol 138 (2002) 510-514
3. Klein A.W. Dilution and storage of botulinum toxin. Dermatol Surg 24 (1998) 1179-1180
4. Khawaja H.A., and Hernandex-Perez E. Botox in dermatology. Int Dermatol 40 (2001) 311-317
5. Hexsel D.M., De Almeida A.T., Rutowitsch M., De Castro I.A., Silviera V.L., Gobatto D.O., et al. Multicenter, double-blind study of the efficacy of injections with botulinum toxin type A reconstituted up to six consecutive weeks before application. Dermatol Surg 29 (2003) 523-529