The impact of antiepileptic drug therapy on steroidal contraceptive efficacy

Epilepsy and Behavior

Volumn 9, Issue 1, 2006, Pages 31-39

  Thorneycroft, Ian ^a,b   Klein, Pavel ^c   Simon, James ^d,e  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b Bay Area Physicians for Women   (United States)

^c Mid Atlantic Epilepsy and Sleep Center   (United States)

^d GEORGE WASHINGTON UNIVERSITY   (United States)

^e Women's Health and Research Consultants   (United States)

Author keywords

Antiepileptic drugs; Contraception; Efficacy; Enzyme induction; Epilepsy; Hepatic metabolism; Steroidal contraceptives; Treatment guidelines; Women

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CONTRACEPTIVE AGENT; ESTRADIOL; ESTROGEN; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS LEVONORGESTREL; ETHINYLESTRADIOL PLUS NORELGESTROMIN; ETHINYLESTRADIOL PLUS NORETHISTERONE ACETATE; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; GESTAGEN; GESTODENE; LAMOTRIGINE; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MESTRANOL; MESTRANOL PLUS NORETHISTERONE; NORETHISTERONE; OGESTREL; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; TIAGABINE; TOPIRAMATE; UNINDEXED DRUG; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

BIRTH DEFECT; CLINICAL TRIAL; DOSE CALCULATION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COMPETITION; DRUG EFFICACY; DRUG ELIMINATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TREATMENT FAILURE; EPILEPSY; FEMALE; HORMONAL CONTRACEPTION; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; LOW DRUG DOSE; MENSTRUAL CYCLE; PRACTICE GUIDELINE; PREGNANCY; PRENATAL DRUG EXPOSURE; REVIEW; UNSPECIFIED SIDE EFFECT;

ANTICONVULSANTS; CONTRACEPTIVE DEVICES; CONTRACEPTIVES, ORAL; DRUG INTERACTIONS; ENZYME INDUCTION; EPILEPSY; ESTROGENS; FEMALE; HUMANS; PROGESTINS;

EID: 33745840146     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2006.05.002     Document Type: Review

References (47)

1. Krauss G.L., Brandt J., Campbell M., et al. Antiepileptic medication and oral contraceptive interactions: a national survey of neurologists and obstetricians. Neurology 46 (1996) 1534-1539
2. Morrell M.J., Sarto G.E., Shafer P.O., et al. Health issues for women with epilepsy: a descriptive survey to assess knowledge and awareness among healthcare providers. J Womens Health Gend Based Med 9 (2000) 959-965
3. Crawford P., and Hudson S. Understanding the information needs of women with epilepsy at different lifestages: results of the 'Ideal World' survey. Seizure 12 (2003) 502-507
4. McAuley J.W., and Anderson G.D. Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations. Clin Pharmacokinet 41 (2002) 559-579
5. Penovich P.E., Eck K.E., and Economou V.V. Recommendations for the care of women with epilepsy. Cleve Clin J Med 71 Suppl. 2 (2004) S49-S57
6. Tettenborn B., Genton P., and Polson D. Epilepsy and women's issues: an update. Epileptic Disord 4 Suppl. 2 (2002) S23-S31
7. Commission on Genetics, Pregnancy, and the Child, International League Against Epilepsy. Guidelines for the care of women of childbearing age with epilepsy. Epilepsia 1993;34:588-9.
8. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 1998;51:944-8.
9. Erkkola R., and Landgren B.M. Role of progestins in contraception. Acta Obstet Gynecol Scand 84 (2005) 207-216
10. Speroff L., and Darney P.D. A clinical guide for contraception. 3rd ed. (2000), Lippincott Williams & Wilkins, Philadelphia
11. Likis F.E. Contraceptive applications of estrogen. J Midwifery Womens Health 47 3 (2002) 139-156
12. Goldzieher J.W., and Rudel H.W. How the oral contraceptives came to be developed. JAMA 230 (1974) 421-425
13. Belsey E.M. Vaginal bleeding patterns among women using one natural and eight hormonal methods of contraception. Contraception 38 (1988) 181-206
14. Lobo R.A. A disorder without identity: "HCA," "PCO," "PCOD," "PCOS," "SLS". what are we to call it?. Fertil Steril 63 (1995) 1158-1160
15. Benagiano G., Primiero F.M., and Farris M. Clinical profile of contraceptive progestins. Eur J Contracept Reprod Health Care 9 (2004) 182-193
16. ChemIndustry.com. Monrovia, CA.
17. Drugs.com. Drugsite Trust. Auckland, New Zealand.
18. Foldvary-Schaefer N., and Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology 61 6, Suppl. 2 (2003) S2-S15
19. Rivera R., Yacobson I., and Grimes D. The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol 181 5, Pt. 1 (1999) 1263-1269
20. Crawford P. Interactions between antiepileptic drugs and hormonal contraception. CNS Drugs 16 (2002) 263-272
21. Crawford P., Chadwick D.J., Martin C., et al. The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids. Br J Clin Pharmacol 30 (1990) 892-896
22. Doose D.R., Wang S.S., Padmanabhan M., et al. Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects. Epilepsia 44 (2003) 540-549
23. Back D.J., Bates M., Bowden A., et al. The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy. Contraception 22 (1980) 495-503
24. Saano V., Glue P., Banfield C.R., et al. Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive. Clin Pharmacol Ther 58 (1995) 523-531
25. ® [package insert]. Greenville, NC: GlaxoSmithKline; 2005.
26. Klosterskov Jensen P., Saano V., Haring P., et al. Possible interaction between oxcarbazepine and an oral contraceptive. Epilepsia 33 (1992) 1149-1152
27. Rosenfeld W.E., Doose D.R., Walker S.A., et al. Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. Epilepsia 38 (1997) 317-323
28. Anderson G.D. Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs. Neurology 63 10, Suppl. 4 (2004) S3-S8
29. Sabers A., Buchholt J.M., Uldall P., et al. Lamotrigine plasma levels reduced by oral contraceptives. Epilepsy Res 47 (2001) 151-154
30. Sabers A., Ohman I., Christensen J., et al. Oral contraceptives reduce lamotrigine plasma levels. Neurology 61 (2003) 570-571
31. Coulam C.B., and Annegers J.F. Do anticonvulsants reduce the efficacy of oral contraceptives?. Epilepsia 20 (1979) 519-525
32. Janz D., and Schmidt D. Anti-epileptic drugs and failure of oral contraceptives [letter]. Lancet 1 (1974) 1113
33. Kenyon I.E. Unplanned pregnancy in an epileptic. Br Med J 1 (1972) 686-687
34. ® [package insert]. Montville, NJ: Berlex; 2003.
35. Bounds W., and Guillebaud J. Observational series on women using the contraceptive Mirena concurrently with anti-epileptic and other enzyme-inducing drugs. J Fam Plann Reprod Health Care 28 (2002) 78-80
36. ® [package insert]. Tonawanda, NY: FEI Products LLC; 2003.
37. ® [package insert]. Kalamazoo, MI: Pharmacia & Upjohn Co.; 2004.
38. O'Brien M.D., and Gilmour-White S.K. Management of epilepsy in women. Postgrad Med J 81 (2005) 278-285
39. Mattson R.H., Cramer J.A., Caldwell B.V., et al. Treatment of seizures with medroxyprogesterone acetate: preliminary report. Neurology 34 (1984) 1255-1258
40. Depo-subQ provera 104™ [package insert]. New York, NY: Pharmacia and Upjohn Co; 2005.
41. ® [package insert]. Raritan, NJ: Ortho-McNeil Pharmaceutical, Inc.; 2005.
42. Holt V.L., Scholes D., Wicklund K.G., et al. Body mass index, weight, and oral contraceptive failure risk. Obstet Gynecol 105 (2005) 46-52
43. Giuliano R.A., Hiersemenzel R., Baltes E., et al. Influence of a new antiepileptic drug (levetiracetam, ucb L059) on the pharmacokinetics and pharmacodynamics of oral contraceptives [abstract]. Epilepsia 37 Suppl. 4 (1996) 90
44. Crawford P., Chadwick D., Cleland P., et al. The lack of effect of sodium valproate on the pharmacokinetics of oral contraceptive steroids. Contraception 33 (1986) 23-29
45. Bartoli A., Gatti G., Cipolla G., et al. A double-blind, placebo-controlled study on the effect of vigabatrin on in vivo parameters of hepatic microsomal enzyme induction and on the kinetics of steroid oral contraceptives in healthy female volunteers. Epilepsia 38 (1997) 702-707
46. Griffith S.G., and Dai Y. Effect of zonisamide on the pharmacokinetics and pharmacodynamics of a combination ethinyl estradiol-norethindrone oral contraceptive in healthy women. Clin Ther 26 (2004) 2056-2065
47. Drugs@FDA. US Food and Drug Administration. Center for Drug Evaluation and Research. Rockville, MD.