Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus

Diseases of the Esophagus

Volumn 19, Issue 4, 2006, Pages 260-266

  Vallbohmer D ^a   DeMeester, S R ^a   Peters, J H ^b   Oh, D S ^a   Kuramochi, H ^a   Shimizu, D ^a   Hagen, J A ^a   Danenberg, K D ^a   Danenberg, P V ^a   DeMeester, T R ^a   Chandrasoma, P T ^a,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c LAC USC MEDICAL CENTER   (United States)

Author keywords

Barrett's esophagus; Biomarker; Cardiac mucosa; Cdx 2; Gastroesophageal reflux disease

Indexed keywords

HOMEODOMAIN PROTEIN; RNA; TRANSCRIPTION FACTOR CDX2;

ARTICLE; BARRETT ESOPHAGUS; COLUMNAR EPITHELIUM; DUODENUM BIOPSY; DUODENUM MUCOSA; ENDOSCOPIC BIOPSY; ESOPHAGUS MUCOSA; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION; HISTOPATHOLOGY; HOMEOBOX; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM; INTESTINE METAPLASIA; INTESTINE MUCOSA; LASER CAPTURE MICRODISSECTION; LOWER ESOPHAGUS SPHINCTER; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SQUAMOUS EPITHELIUM; STOMACH MUCOSA; TISSUE DIFFERENTIATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BARRETT ESOPHAGUS; CELL TRANSFORMATION, NEOPLASTIC; DUODENUM; ESOPHAGEAL NEOPLASMS; ESOPHAGOGASTRIC JUNCTION; ESOPHAGUS; FEMALE; GASTRIC MUCOSA; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION; GENETIC MARKERS; HOMEODOMAIN PROTEINS; HUMANS; INTESTINAL MUCOSA; MALE; METAPLASIA; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION;

EID: 33745838193     PISSN: 11208694     EISSN: 14422050     Source Type: Journal    
DOI: 10.1111/j.1442-2050.2006.00586.x     Document Type: Article

References (38)

1. Liebermann-Meffert D, Duranceau A, Stein H J. Anatomy and Embryology. In: Orringer M B H R, Zudeima G D, Yeo C J, eds. Shackelford's Surgery of the Alimentary Tract, Vol. 3. Philadelphia, PA: W.B. Saunders Company 2002, 3-39.
2. Menard D, Arsenault P. Cell proliferation in developing human stomach. Anat Embryol 1990; 182: 509-16.
3. DeMeester S R, DeMeester T R. Columnar mucosa and intestinal metaplasia of the esophagus: Fifty years of controversy. Ann Surg 2000; 231: 303-21.
4. Skinner D B, Walther B C, Riddell R H et al. Barrett's esophagus. Comparison of benign and malignant cases. Ann Surg 1983; 198: 554-65.
5. Freund J N, Domon-Dell C, Kedinger M, Duluc I. The Cdx-1 and Cdx-2 homeobox genes in the intestine. Biochem Cell Biol 1998; 76: 957-69.
6. Silberg D G, Swain G P, Suh E R, Traber P G. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000; 119: 961-71.
7. Beck F, Chawengsaksophak K, Waring P et al. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci United States America 1999; 96: 7318-23.
8. Phillips R W, Frierson H F Jr, Moskaluk C A. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. [see comment]. Am J Surg Pathol 2003; 27: 1442-7.
9. Groisman G M, Amar M, Meir A. Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barrett's) metaplasia. Modern Pathol 2004; 17: 1282-8.
10. Paull A, Trier J S, Dalton M D et al. The histologic spectrum of Barrett's esophagus. N Engl J Med 1976; 295: 476-80.
11. Chandrasoma P T, Lokuhetty D M, Demeester T R et al. Definition of histopathologic changes in gastroesophageal reflux disease. [see comment] Am J Surg Pathol 2000; 24: 344-51.
12. Bonner R F, Emmert-Buck M, Cole K et al. Laser capture microdissection: Molecular analysis of tissue. Science 1997; 278: 1483.
13. Lord R V, Salonga D, Danenberg K D et al. Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence. J Gastrointestinal Surg 2000; 4: 135-42.
14. Petrie A, Sabin C. Medical Statistics at A Glance. Malden, MA: Blackwell Science 2000.
15. Hayward J. The lower end of the esophagus. Thorax 1961; 16: 36-41.
16. Tobey N A, Carson J L, Alkiek R A, Orlando R C. Dilated intercellular spaces: A morphological feature of acid reflux - damaged human esophageal epithelium. Gastroenterology 1996; 111: 1200-5.
17. Villanacci V, Grigolato P G, Cestari R et al. Dilated intercellular spaces as markers of reflux disease: Histology, semiquantitative score and morphometry upon light microscopy. Digestion 2001; 64: 1-8.
18. Tobey N A, Hosseini S S, Argote C M et al. Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol 2004; 99: 13-22.
19. Chandrasoma P T, Der R, Ma Y et al. Histology of the gastroesophageal junction: An autopsy study. [see comment]. Am J Surg Pathol 2000; 24: 402-9.
20. Prach A T, MacDonald T A, Hopwood D A, Johnston D A. Increasing incidence of Barrett's oesophagus: Education, enthusiasm, or epidemiology? Lancet 1997; 350: 933.
21. Botterweck A A, Schouten L J, Volovics A et al. Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries. Int J Epidemiol 2000; 29: 645-54.
22. Mendes de Almeida J C, Chaves P, Pereira A D, Altorki N K. Is Barrett's esophagus the precursor of most adenocarcinomas of the esophagus and cardia? A biochemical study. Ann Surg 1997; 226: 725-33; discussion 733-5.
23. Rogge-Wolf C, Seldenrijk C A, Das K M et al. Prevalence of mabDAS-1 positivity in biopsy specimens from the esophagogastric junction. [see comment]. Am J Gastroenterol 2002; 97: 2979-85.
24. Zwas F, Shields H M, Doos W G et al. Scanning electron microscopy of Barrett's epithelium and its correlation with light microscopy and mucin stains. Gastroenterology 1986; 90: 1932-41.
25. Wijnhoven B P, Tilanus H W, Dinjens W N. Molecular biology of Barrett's adenocarcinoma. Ann Surg 2001; 233: 322-37.
26. Chandrasoma P. Pathological basis of gastroesophageal reflux disease. World J Surg 2003; 27: 986-93.
27. Hamilton S R, Yardley J H. Regnerative of cardiac type mucosa and acquisition of Barrett mucosa after esophagogastrostomy. Gastroenterology 1977; 72: 669-75.
28. Oberg S, Johansson J, Wenner J, Walther B. Metaplastic columnar mucosa in the cervical esophagus after esophagectomy. Ann Surg 2002; 235: 338-45.
29. Lord R V N, Wickramasinghe K, Johansson J J et al. Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett's-like features. Surgery 2004; 136: 633-40.
30. Cooper J E, Spitz L, Wilkins B M. Barrett's esophagus in children: A histologic and histochemical study of 11 cases. J Pediatric Surg 1987; 22: 191-6.
31. Qualman S J, Murray R D, McClung H J, Lucas J. Intestinal metaplasia is age related in Barrett's esophagus. Arch Pathol Laboratory Med 1990; 114: 1236-40.
32. Csendes A, Maluenda F, Braghetto I et al. Location of the lower oesophageal sphincter and the squamous columnar mucosal junction in 109 healthy controls and 778 patients with different degrees of endoscopic oesophagitis. Gut 1993; 34: 21-7.
33. Kazumori H I S, Ishihara S, Rumi M A, Kadowaki Y, Kinoshita Y. Bile acids directly augment caudal-related homeobox gene Cdx-2 expression in esophageal keratinocytes in Barrett's epithelium. Gut 2005; Published online ahead of print .
34. Kauer W K, Peters J H, DeMeester T R et al. Mixed reflux of gastric and duodenal juices is more harmful to the esophagus than gastric juice alone. The need for surgical therapy re-emphasized. [see comment]. Ann Surg 1995; 222: 525-31; discussion 531-3.
35. Fein M, Ireland A P, Ritter M P et al. Duodenogastric reflux potentiates the injurious effects of gastroesophageal reflux. J Gastrointestinal Surg 1997; 1: 27-33.
36. Campos G M, DeMeester S R, Peters J H et al. Predictive factors of Barrett esophagus: Multivariate analysis of 502 patients with gastroesophageal reflux disease. Arch Surg 2001; 136: 1267-73.
37. Poleynard G D, Marty A T, Birnbaum W B et al. Adenocarcinoma in the columnar-lined (Barrett) esophagus. Case report and review of the literature. Arch Surg 1977; 112: 997-1000.
38. Uesaka T, Kageyama N, Watanabe H. Identifying target genes regulated downstream of Cdx2 by microarray analysis. J Mol Biol 2004; 337: 647-60.