Inhibitory effects of mizolastine on ultraviolet B-induced leukotriene B4 production and 5-lipoxygenase expression in normal human dermal fibroblasts in vitro

Photochemistry and Photobiology

Volumn 82, Issue 3, 2006, Pages 665-669

  Yan, Yan ^a   Wang, Baoxi ^a   Zuo, Ya Gang ^a   Qu, Tao ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; LEUKOTRIENE B4; LIPOXYGENASE; MIZOLASTINE; RADIOPROTECTIVE AGENT;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENETICS; HUMAN; METABOLISM; RADIATION EXPOSURE; SKIN; ULTRAVIOLET RADIATION;

BENZIMIDAZOLES; CELLS, CULTURED; FIBROBLASTS; HUMANS; LEUKOTRIENE B4; LIPOXYGENASE; RADIATION-PROTECTIVE AGENTS; SKIN; ULTRAVIOLET RAYS;

ORYCTOLAGUS CUNICULUS;

EID: 33745831584     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/2005-08-17-RA-652     Document Type: Article

References (18)

1. Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa and T. Shimizu (1997) A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-624.
2. Chan, C. C. and A. Ford-Hutchinson (1985) Effects of synthetic leukotrienes on local blood flow and vascular permeability in porcine skin. J. Invest. Dermatol. 84, 154-157.
3. Serhan, C. N., A. Radin, J. E. Smolen, H. Korchak, B. Samuelsson and G. Weissmann (1982) Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochem. Biophys. Res. Commun. 107, 1006-1012.
4. Nakaguma, H. and H. Takahashi (1990) Remarkable elevation of leukotriene B4 in rat skin after induction of UV photodermatitis. Inflammation 14, 195-203.
5. Grundmann, J. U., R. Bockelmann, B. Bonnekoh and H. P. Gollnick (2001) UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin. Photochem. Photobiol. 74, 587-592.
6. Breton, J., D. Woolf, P. Young and M. Chabot-Fletcher (1996) Human keratinocytes lack the components to produce leukotriene B4. J. Investig. Dermatol. 106, 162-167.
7. Lewis, R. A., K. F. Austen and R. J. Soberman (1990) Leukotrienes and other products of the 5-lipoxygenase pathway: biochemistry and relation to pathobiology in human disease. N. Engl. J. Med. 323, 645-655.
8. Kowal-Bielecka, O., O. Distler, M. Neidhart, P. Kunzler, J. Rethage, M. Nawrath, A. Carossino, T. Pap, U. Muller-Ladner, B. A. Michel, S. Sierakowski, M. Matucci-Cerinic, R. E. Gay and S. Gay (2001) Evidence of 5-lipoxygenase overexpression in the skin of patients with systemic sclerosis: a newly identified pathway to skin inflammation in systemic sclerosis. Arthritis Rheum. 44, 1865-1875.
9. Smith, R. S., T. J. Smith, T. M. Blieden and R. P. Phipps (1997) Fibroblasts as sentinel cells: synthesis of chemokines and regulation of inflammation. Am. J. Pathol. 151, 317-322.
10. Baroody, F. M. and R. M. Naclerio (2000) Antiallergic effects of H1-receptor antagonists. Allergy 55 (Suppl. 64), 17-27.
11. Sudo, K., K. Nagai and N. Yamada (1998) Inhibitory effect of mizolastine on 5-lipoxygenase. Jpn. Pharmacol. Ther. 26, 155-157.
12. Luo, M., S. M. Jones, M. Peters-Golden and T. G. Brock (2003) Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc. Natl. Acad. Sci. U. S. A. 100, 12165-12170.
13. Woods, J., M. Coffey, T. Brock, I. Singer and M. Peters-Golden (1995) 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J. Clin. Investig. 95, 2035-2046.
14. 2 to the nuclear fraction upon macrophage activation. Biochem. Biophys. Res. Commun. 196, 147-153.
15. Chen, X.-S., T. Naumann, U. Kurre, N. Jenkins, N. Copeland and C. Funk (1995) cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. J. Biol. Chem. 270, 17993-17999.
16. Brock, T. G., R. W. McNish and M. Peters-Golden (1995) Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J. Biol. Chem. 270, 21652-21658.
17. Brock, T., R. McNish, M. Bailie and M. Peters-Golden (1997) Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils following in vivo recruitment and in vitro adherence. J. Biol. Chem. 272, 8276-8280.
18. Brock, T. G., J. A. Anderson, F. P. Fries, M. Peters-Golden and P. H. Sporn (1999) Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. J. Immunol. 162, 1669-1676.