The Clinical and Laboratory Response to Recombinant Factor VIIa in Trauma and Surgical Patients with Acquired Coagulopathy

Current Surgery

Volumn 63, Issue 4, 2006, Pages 246-251

  McMullin, Neil R ^a   Kauvar, David S ^a   Currier, Heather M ^a   Baskin, Toney W ^a   Pusateri, Anthony E ^a   Holcomb, John B ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

coagulopathy; hemorrhage; recombinant factor VIIa; thromboembolism; trauma

Indexed keywords

FIBRINOGEN; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; INJURY; INTERNATIONAL NORMALIZED RATIO; MALE; PARTIAL THROMBOPLASTIN TIME; PH; PLASMA TRANSFUSION; PRIORITY JOURNAL; PROTHROMBIN TIME; RETROSPECTIVE STUDY; SURGICAL MORTALITY; SURGICAL PATIENT; SURVIVAL; TEMPERATURE;

ADOLESCENT; ADULT; AGED; BLOOD COAGULATION DISORDERS; CRITICAL ILLNESS; FACTOR VII; FACTOR VIIA; HEMOSTATICS; HUMANS; MIDDLE AGED; POSTOPERATIVE PERIOD; PROTHROMBIN TIME; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; SURGICAL PROCEDURES, OPERATIVE; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 33745828111     PISSN: 01497944     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cursur.2006.03.007     Document Type: Article

References (25)

1. MacLeod J.B., McKenney M.G., Cohn S.M., and Murtha M. Early coagulopathy predicts mortality in trauma. LM. J Trauma 55 (2003) 39-44
2. Kenet G., Walden R., Eldad A., and Martinowitz U. Treatment of traumatic bleeding with recombinant factor VIIa. Lancet 354 (1999) 1879
3. Dutton R.P., Hess J.R., and Scalea T.M. Recombinant factor VIIa for control of hemorrhage. early experience in critically ill trauma patients. J Clin Anesth 15 (2003) 184-188
4. Dutton R.P., McCunn M., Hyder M., et al. Factor VIIa for correction of traumatic coagulopathy. J Trauma 57 (2004) 709-719
5. Geeraedts Jr. L.M., Kamphuisen P.W., Kaasjager H.A., Verwiel J.M., van Vugt A.B., and Frolke J.P. The role of recombinant factor VIIa in the treatment of life-threatening haemorrhage in blunt trauma. Injury 36 (2005) 495-500
6. Jeroukhimov I.J.D., Zaias J., Hensley G., et al. Early injection of high-dose recombinant factor VIIa decreases blood loss and prolongs time from injury to death in experimental liver injury. J Trauma 53 (2002) 1053-1057
7. Lynn M.J.I., Jewelewicz D., Popkin C., et al. Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock. a pilot study. J Trauma 52 (2002) 703-707
8. Martinowitz U.H.J., Pusateri A.E., Stein M., et al. Intravenous rFVIIa administered for hemorrhage control in hypothermic coagulopathic swine with grade V liver injuries. J Trauma 50 (2001) 721-729
9. Schreiber M.A., Hedner U., Brundage S.I., Macaitis J.M., and Hoots K. The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries. HJ. J Trauma 53 (2002) 252-259
10. Sondeen J.L., Pusateri A.E., Hedner U., Yantis L.D., and Holcomb J.B. Recombinant factor VIIa increases the pressure at which rebleeding occurs in porcine uncontrolled aortic hemorrhage model. Shock 22 (2004) 163-168
11. Boffard K.D., Riou B., Warren B., et al. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients. two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma 59 1 (2005) 8-15 discussion 15-18
12. Eikelboom J.W., Bird R., Blythe D., et al. Recombinant activated factor VII for the treatment of life-threatening haemorrhage. Blood Coagul Fibrinolysis 14 (2003) 713-717
13. Martinowitz U., and Michaelson M. Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding. a report by the Israeli Multidisciplinary rFVIIa Task Force. J Thromb Haemost 3 (2005) 640-648
14. Jeffers L., Chalasani N., Balart L., Pyrsopoulos N., and Erhardtsen E. Safety and efficacy of recombinant factor VIIa in patients with liver disease undergoing laparoscopic liver biopsy. Gastroenterology 123 1 (2002) 118-126
15. Almeida A.M., Khair K., Hann I., and Liesner R. The use of recombinant factor VIIa in children with inherited platelet function disorders. Br J Haematol 121 (2003) 477-481
16. Friederich P.W., Henny C.P., Messelink E.J., et al. Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy. a double-blind placebo-controlled randomised trial. Lancet 361 (2003) 201-205
17. Hamilton S. The use of blood in resuscitation of the trauma patient. Can J Surg 36 1 (1993) 21-27
18. Ferrara A., Wright J.M., Modlin H.K., and McMillen M.A. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion. Am J Surg 160 (1990) 515-518
19. O'Connell K.A., Wood J.J., Wise R.P., Lozier J.N., and Braun M.M. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA 295 (2006) 293-298
20. Lodge J.P., Jonas S., Jones R.M., et al. Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation. Liver Transpl 11 (2005) 973-979
21. Lodge J.P., Jonas S., Oussoultzoglou E., et al. Recombinant coagulation factor VIIa in major liver resection. a randomized, placebo-controlled, double-blind clinical trial. Anesthesiology 102 (2005) 269-275
22. Mayer S.A., Brun N.C., Begtrup K., et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352 (2005) 777-785
23. Planinsic R.M., van der Meer J., Testa G., et al. Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease. Liver Transpl 11 (2005) 895-900
24. Diprose P., Herbertson M.J., O'Shaughnessy D., and Gill R.S. Activated recombinant factor VII after cardiopulmonary bypass reduces allogeneic transfusion in complex non-coronary cardiac surgery. randomized double-blind placebo-controlled pilot study. Br J Anaesth 95 (2005) 596-602
25. Bosch J., Thabut D., Bendtsen F., et al. Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis. a randomized, double-blind trial. Gastroenterology 127 (2004) 1123-1130